Related papers: Modeling the Mitral Valve
The plasma membrane of human red blood cells consists of a lipid bilayer attached to a regular network of underlying cytoskeletal polymers. We model this system at a dynamic coarse-grained level, treating the bilayer as an elastic sheet and…
Heart disease is one of leading causes of mortality worldwide. Healthy heart valves are key for proper heart function. When these valves dysfunction, a replacement is often necessary in severe cases. The current study presents an…
Since myocardial fibers drive the electric signal propagation throughout the myocardium, accurately modeling their arrangement is essential for simulating heart electrophysiology (EP). Rule-Based-Methods (RBMs) represent a commonly used…
We present a new computational model for the numerical simulation of blood flow in the human left heart. To this aim, we use the Navier-Stokes equations in an Arbitrary Lagrangian Eulerian formulation to account for the endocardium motion…
Esophageal transport is a physiological process that mechanically transports an ingested food bolus from the pharynx to the stomach via the esophagus, a multi-layered muscular tube. This process involves interactions between the bolus, the…
Understanding the biomechanics of the heart in health and disease plays an important role in the diagnosis and treatment of heart failure. The use of computational biomechanical models for therapy assessment is paving the way for…
To go beyond the simple model for the fold as two flexible surfaces or faces linked by a crease that behaves as an elastic hinge, we carefully shape and anneal a crease within a polymer sheet and study its mechanical response. First, we…
Measuring the mechanical properties of cells and tissues often involves indentation with a sphere, or compression between two plates. Previously, different theoretical approaches have been developed to retrieve material parameters (e.g.…
We consider a multiscale approach based on immersed methods for the efficient computational modeling of tissues composed of an elastic matrix (in two or three-dimensions) and a thin vascular structure (treated as a co-dimension two…
Computational simulations have the potential to assist in liver resection surgeries by facilitating surgical planning, optimizing resection strategies, and predicting postoperative outcomes. The modeling of liver tissue across multiple…
Purpose: Transcatheter edge-to-edge repair (TEER) and annuloplasty devices are increasingly used to treat mitral valve regurgitation, yet their mechanical effects and interactions remain poorly understood. This study aimed to establish an…
The physical mechanism on meridians (acupuncture lines) is studied and a theoretical model is proposed. The meridians are explained as an alternating system responsible for the integration and the regulation of life in addition to the…
Heart murmurs are a common manifestation of cardiovascular diseases and can provide crucial clues to early cardiac abnormalities. While most current research methods primarily focus on the accuracy of models, they often overlook other…
We present a novel mathematical model that simulates myocardial blood perfusion by embedding multiscale and multiphysics features. Our model incorporates cardiac electrophysiology, active and passive mechanics, hemodynamics, reduced valve…
In order to describe two-dimensionally packed cells in epithelial tissues both mathematically and physically, there have been developed several sorts of geometrical models, such as the vertex model, the finite element model, the…
The blood vascular system consists of blood vessels such as arteries, arterioles, capillaries and veins that convey blood throughout the body. The pressure difference which exists between the ends of the vessels provides the living force…
Excitable membranes are an important type of nonlinear dynamical system and their study can be used to provide a connection between physical and biological circuits. We discuss two models of excitable membranes important in cardiac and…
Encapsulation of chemicals using polymer membranes enables to control their transport and delivery for applications such as agrochemistry or detergency. To rationalize the design of polymer capsules, it is necessary to understand how the…
This study uses a one dimensional fluid dynamics arterial network model to infer changes in hemodynamic quantities associated with pulmonary hypertension in mice. Data for this study include blood flow and pressure measurements from the…
An experimental study is reported which investigates the wall shear stress (WSS) distribution in a transparent model of the human aorta comparing a bileaflet mechanical heart valve (BMHV) with a trileaflet mechanical heart valve (TMHV) in…