Related papers: Modeling the Mitral Valve
Blood vessel constriction is simulated with particle-based method using a molecular dynamics authoring software known as Molecular Workbench (WM). Blood flow and vessel wall, the only components considered in constructing a blood vessel,…
The circulatory system, comprising the heart and blood vessels, is vital for nutrient transport, waste removal, and homeostasis. Traditional computational models often treat cardiac electromechanics and blood flow dynamics separately,…
Cardiac disease and clinical intervention may both lead to an increased risk for thrombosis events due to modified blood flow in the heart, and thereby a change in the mechanical stimuli of blood cells passing through the chambers of the…
We study the formation of the mitral vortex ring during early diastolic filling in a patient-specific left ventricle (LV) using direct numerical simulation. The geometry of the left ventricle is reconstructed from Magnetic Resonance Imaging…
It has long been recognized that aortic root elasticity helps to ensure efficient aortic valve closure, but our understanding of the functional importance of the elasticity and geometry of the aortic root continues to evolve as increasingly…
Rule-based methods are often used for assigning fiber orientation to cardiac anatomical models. However, existing methods have been developed using data mostly from the left ventricle. As a consequence, fiber information obtained from…
Mathematical models of cardiac electrical activity are one of the most important tools for elucidating information about the heart diagnostic. Even though it is one of the major problems in biomedical research, an efficient mathematical…
While ventricular electromechanics is extensively studied, four-chamber heart models have only been addressed recently; most of these works however neglect atrial contraction. Indeed, as atria are characterized by a complex physiology…
Internal haemorrhage, often leading to cardio-vascular arrest happens to be one of the prime sources of high fatality rates in mammals. We propose a simplistic model of fluid flow to specify the location of the haemorrhagic spots, which, if…
Advances in three-dimensional imaging provide the ability to construct and analyze finite element (FE) models to evaluate the biomechanical behavior and function of atrioventricular valves. However, while obtaining patient-specific valve…
Before septation processes shape its four chambers, the embryonic heart is a straight tube that spontaneously bends and twists breaking the left-right symmetry. In particular, the heart tube is subjected to a cell remodelling inducing…
Deformable shape modeling approaches that describe objects in terms of their medial axis geometry (e.g., m-reps [Pizer et al., 2003]) yield rich geometrical features that can be useful for analyzing the shape of sheet-like biological…
Atrioventricular valve regurgitation is a significant cause of morbidity and mortality in patients with acquired and congenital cardiac valve disease. Image-derived computational modeling of atrioventricular valves has advanced…
We carry out Monte Carlo simulations of a colloidal fluid membrane composed of chiral rod-like viruses. The membrane is modeled by a triangular mesh of beads connected by bonds in which the bonds and beads are free to move at each Monte…
Image-based computational fluid dynamics (CFD) has emerged as a powerful tool to study cardiovascular flows while 2D echocardiography (echo) is the most widely used non-invasive imaging modality for diagnosis of heart disease. Here, echo is…
In this study, we present a comprehensive numerical analysis of blood flow within human left ventricle models, with particular emphasis on optimizing simulation conditions to enhance the realism and computational efficiency of heart flow…
The segmentation of the mitral valve annulus and leaflets specifies a crucial first step to establish a machine learning pipeline that can support physicians in performing multiple tasks, e.g.\ diagnosis of mitral valve diseases, surgical…
In this paper we introduce a computational modelling that reproduces the breast compression processes used to obtain the mammogram. The main result is a programme in which one can track the first steps of virtual mammography. On the one…
There are more than 300,000 heart valves implanted annually worldwide with about 50% of them being mechanical valves. The heart valve replacement is often a common treatment for severe valvular disease. However, valves may dysfunction…
Two crucial factors for accurate numerical simulations of cardiac electromechanics, which are also essential to reproduce the synchronous activity of the heart, are: i) accounting for the interaction between the heart and the circulatory…