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Partial synchronization plays a crucial role in the functioning of neuronal networks: selective, coordinated activation of neurons enables information processing that flexibly adapts to a changing computational context. Since the structure…

Neurons and Cognition · Quantitative Biology 2025-06-17 Daniil Radushev , Olesia Dogonasheva , Boris Gutkin , Denis Zakharov

Structural and functional neuroimaging modalities provide complementary windows into brain organization: structural imaging characterizes neural tissue anatomy and microstructure, while functional imaging captures dynamic patterns of neural…

Methodology · Statistics 2026-03-24 Sakul Mahat , Sharmistha Guha , Jessica Bernard

Cognitive effort, defined as the relationship between cognitive load and task performance, provides insight into how individuals allocate mental resources during demanding tasks. This construct is particularly important in high-stakes…

Human-Computer Interaction · Computer Science 2026-04-13 Shayla Sharmin , Mohammad Fahim Abrar , Gael Lucero-Palacios , Aditya Raikwar , Roghayeh Leila Barmaki

The current neuron reconstruction pipeline for electron microscopy (EM) data usually includes automatic image segmentation followed by extensive human expert proofreading. In this work, we aim to reduce human workload by predicting…

Computer Vision and Pattern Recognition · Computer Science 2024-01-09 Qihua Chen , Xuejin Chen , Chenxuan Wang , Yixiong Liu , Zhiwei Xiong , Feng Wu

A key problem in network theory is how to reconfigure a graph in order to optimize a quantifiable objective. Given the ubiquity of networked systems, such work has broad practical applications in a variety of situations, ranging from drug…

Machine Learning · Computer Science 2023-01-31 Christoffel Doorman , Victor-Alexandru Darvariu , Stephen Hailes , Mirco Musolesi

Mental and cognitive representations are believed to reside on low-dimensional, non-linear manifolds embedded within high-dimensional brain activity. Uncovering these manifolds is key to understanding individual differences in brain…

Machine Learning · Computer Science 2025-05-02 Eloy Geenjaar , Vince Calhoun

The brain is a paradigmatic example of a complex system as its functionality emerges as a global property of local mesoscopic and microscopic interactions. Complex network theory allows to elicit the functional architecture of the brain in…

Neurons and Cognition · Quantitative Biology 2017-01-18 Rossana Mastrandrea , Andrea Gabrielli , Fabrizio Piras , Gianfranco Spalletta , Guido Caldarelli , Tommaso Gili

We introduce a novel, data-driven topological data analysis (TDA) approach for embedding brain networks into a lower-dimensional space in quantifying the dynamics of temporal lobe epilepsy (TLE) obtained from resting-state functional…

What role does phenotypic complexity play in the systems-level function of an embodied agent? The organismal phenotype is a topologically complex structure that interacts with a genotype, developmental physics, and an informational…

Neurons and Cognition · Quantitative Biology 2022-08-15 Bradly Alicea , Jesse Parent

Automatic segmentation of fine-grained brain structures remains a challenging task. Current segmentation methods mainly utilize 2D and 3D deep neural networks. The 2D networks take image slices as input to produce coarse segmentation in…

Computer Vision and Pattern Recognition · Computer Science 2019-05-08 Yuemeng Li , Hangfan Liu , Hongming Li , Yong Fan

We present a novel topological framework for analyzing functional brain signals using time-frequency analysis. By integrating persistent homology with time-frequency representations, we capture multi-scale topological features that…

Neurons and Cognition · Quantitative Biology 2025-04-23 Moo K. Chung , Aaron F. Struck

Modeling the behavior of coupled networks is challenging due to their intricate dynamics. For example in neuroscience, it is of critical importance to understand the relationship between the functional neural processes and anatomical…

Machine Learning · Computer Science 2021-04-20 Hongyuan You , Sikun Lin , Ambuj K. Singh

Brain function relies on a precisely coordinated and dynamic balance between the functional integration and segregation of distinct neural systems. Characterizing the way in which neural systems reconfigure their interactions to give rise…

Neurons and Cognition · Quantitative Biology 2021-01-28 Lingbin Bian , Tiangang Cui , B. T. Thomas Yeo , Alex Fornito , Adeel Razi , Jonathan Keith

Understanding how brain structure and function interact is key to explaining intelligence yet modeling them jointly is challenging as the structural and functional connectome capture complementary aspects of organization. We introduced…

Computer Vision and Pattern Recognition · Computer Science 2026-04-01 Badhan Mazumder , Sir-Lord Wiafe , Aline Kotoski , Vince D. Calhoun , Dong Hye Ye

Converging evidence indicates that the heterogeneity of cognitive profiles may arise through detectable alternations in brain functions. Particularly, brain functional connectivity, measured under resting and cognitive states, characterizes…

Applications · Statistics 2023-02-22 Tianqi Chen , Chichun Tan , Hongyu Zhao , Todd Constable , Sarah Yip , Yize Zhao

Automated sample preparation and electron microscopy enables acquisition of very large image data sets. These technical advances are of special importance to the field of neuroanatomy, as 3D reconstructions of neuronal processes at the nm…

Functional brain networks can change rapidly as a function of stimuli or cognitive shifts. Tracking dynamic functional connectivity is particularly challenging as it requires estimating the structure of the network at each moment as well as…

Methodology · Statistics 2024-04-30 Wan-Chi Hsin , Uri T. Eden , Emily P. Stephen

Human brains are commonly modeled as networks of Regions of Interest (ROIs) and their connections for the understanding of brain functions and mental disorders. Recently, Transformer-based models have been studied over different types of…

Machine Learning · Computer Science 2022-10-18 Xuan Kan , Wei Dai , Hejie Cui , Zilong Zhang , Ying Guo , Carl Yang

Human activity understanding with 3D/depth sensors has received increasing attention in multimedia processing and interactions. This work targets on developing a novel deep model for automatic activity recognition from RGB-D videos. We…

Computer Vision and Pattern Recognition · Computer Science 2017-08-01 Keze Wang , Xiaolong Wang , Liang Lin , Meng Wang , Wangmeng Zuo

Training neural networks to perform different tasks is relevant across various disciplines. In particular, Recurrent Neural Networks (RNNs) are of great interest in Computational Neuroscience. Open-source frameworks dedicated to Machine…

Machine Learning · Computer Science 2023-08-01 Cecilia Jarne