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Genes are often regulated in living cells by proteins called transcription factors (TFs) that bind directly to short segments of DNA in close proximity to specific genes. These binding sites have a conserved nucleotide appearance, which is…

Statistics Theory · Mathematics 2007-06-13 Shane T. Jensen , Jun S. Liu

Bayesian clustering methods have the widely touted advantage of providing a probabilistic characterization of uncertainty in clustering through the posterior distribution. An amazing variety of priors and likelihoods have been proposed for…

Methodology · Statistics 2025-11-21 Garritt L. Page , Andrés F. Barrientos , David B. Dahl , David B. Dunson

Conformal prediction (CP) is widely presented as distribution-free predictive inference with finite-sample marginal coverage under exchangeability. We argue that CP is best understood as a rank-calibrated descendant of the…

Statistics Theory · Mathematics 2025-12-30 Jyotishka Datta , Nicholas G. Polson , Vadim Sokolov , Daniel Zantedeschi

The domain of explainable AI is of interest in all Machine Learning fields, and it is all the more important in clustering, an unsupervised task whose result must be validated by a domain expert. We aim at finding a clustering that has high…

Artificial Intelligence · Computer Science 2024-03-28 Mathieu Guilbert , Christel Vrain , Thi-Bich-Hanh Dao

Bayesian clustering accounts for uncertainty but is computationally demanding at scale. Furthermore, real-world datasets often contain missing values, and simple imputation ignores the associated uncertainty, resulting in suboptimal…

Machine Learning · Computer Science 2026-03-18 Prajit Bhaskaran , Tom Viering

The marginal Bayesian predictive classifiers (mBpc) as opposed to the simultaneous Bayesian predictive classifiers (sBpc), handle each data separately and hence tacitly assumes the independence of the observations. However, due to…

Machine Learning · Statistics 2021-12-06 Ali Amiryousefi , Ville Kinnula , Jing Tang

A common divide-and-conquer approach for Bayesian computation with big data is to partition the data, perform local inference for each piece separately, and combine the results to obtain a global posterior approximation. While being…

In many modern applications, there is interest in analyzing enormous data sets that cannot be easily moved across computers or loaded into memory on a single computer. In such settings, it is very common to be interested in clustering.…

Computation · Statistics 2020-05-15 Hanyu Song , Yingjian Wang , David B. Dunson

Clustering attempts to partition data instances into several distinctive groups, while the similarities among data belonging to the common partition can be principally reserved. Furthermore, incomplete data frequently occurs in many…

Machine Learning · Computer Science 2022-08-30 Miao Cheng , Xinge You

Variation in the evolutionary process across the sites of nucleotide sequence alignments is well established, and is an increasingly pervasive feature of datasets composed of gene regions sampled from multiple loci and/or different genomes.…

Populations and Evolution · Quantitative Biology 2014-09-04 Brian R. Moore , Jim McGuire , Fredrik Ronquist , John P. Huelsenbeck

Change-point models deal with ordered data sequences. Their primary goal is to infer the locations where an aspect of the data sequence changes. In this paper, we propose and implement a nonparametric Bayesian model for clustering…

Methodology · Statistics 2025-02-12 Ana Carolina da Cruz , Camila P. E. de Souza

Traditional Bayesian random partition models assume that the size of each cluster grows linearly with the number of data points. While this is appealing for some applications, this assumption is not appropriate for other tasks such as…

Methodology · Statistics 2020-04-07 Brenda Betancourt , Giacomo Zanella , Rebecca C. Steorts

Consensus clustering fuses diverse basic partitions (i.e., clustering results obtained from conventional clustering methods) into an integrated one, which has attracted increasing attention in both academic and industrial areas due to its…

Machine Learning · Computer Science 2019-06-04 Hongfu Liu , Zhiqiang Tao , Zhengming Ding

Initialisation of the EM algorithm in model-based clustering is often crucial. Various starting points in the parameter space often lead to different local maxima of the likelihood function and, so to different clustering partitions. Among…

Methodology · Statistics 2015-07-28 Luca Scrucca , Adrian E. Raftery

Mixture models are commonly used in applications with heterogeneity and overdispersion in the population, as they allow the identification of subpopulations. In the Bayesian framework, this entails the specification of suitable prior…

Methodology · Statistics 2023-06-21 Andrea Cremaschi , Timothy M. Wertz , Maria De Iorio

Loss-based clustering methods, such as k-means and its variants, are standard tools for finding groups in data. However, the lack of quantification of uncertainty in the estimated clusters is a disadvantage. Model-based clustering based on…

Methodology · Statistics 2020-06-11 Tommaso Rigon , Amy H. Herring , David B. Dunson

To identify novel dynamic patterns of gene expression, we develop a statistical method to cluster noisy measurements of gene expression collected from multiple replicates at multiple time points, with an unknown number of clusters. We…

Applications · Statistics 2013-12-02 Audrey Qiuyan Fu , Steven Russell , Sarah J. Bray , Simon Tavaré

In many scientific domains, clustering aims to reveal interpretable latent structure that reflects relevant subpopulations or processes. Widely used Bayesian mixture models for model-based clustering often produce overlapping or redundant…

Methodology · Statistics 2025-10-13 Ziyi Song , Federico Camerlenghi , Weining Shen , Michele Guindani , Mario Beraha

This paper presents a novel clustering concept that is based on jointly learned nonlinear transforms (NTs) with priors on the information loss and the discrimination. We introduce a clustering principle that is based on evaluation of a…

Machine Learning · Computer Science 2019-01-31 Dimche Kostadinov , Behrooz Razeghi , Taras Holotyak , Slava Voloshynovskiy

To cluster data is to separate samples into distinctive groups that should ideally have some cohesive properties. Today, numerous clustering algorithms exist, and their differences lie essentially in what can be perceived as ``cohesive…

Machine Learning · Statistics 2025-05-08 Louis Ohl , Pierre-Alexandre Mattei , Frédéric Precioso