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In data-driven drug discovery, designing molecular descriptors is a very important task. Deep generative models such as variational autoencoders (VAEs) offer a potential solution by designing descriptors as probabilistic latent vectors…

Machine Learning · Computer Science 2023-08-23 Daiki Koge , Naoaki Ono , Shigehiko Kanaya

We show that a generative random field model, which we call generative ConvNet, can be derived from the commonly used discriminative ConvNet, by assuming a ConvNet for multi-category classification and assuming one of the categories is a…

Machine Learning · Statistics 2016-06-01 Jianwen Xie , Yang Lu , Song-Chun Zhu , Ying Nian Wu

In this work, we propose a new generative model that is capable of automatically decoupling global and local representations of images in an entirely unsupervised setting, by embedding a generative flow in the VAE framework to model the…

Computer Vision and Pattern Recognition · Computer Science 2021-03-17 Xuezhe Ma , Xiang Kong , Shanghang Zhang , Eduard Hovy

Implicit generative models have the capability to learn arbitrary complex data distributions. On the downside, training requires telling apart real data from artificially-generated ones using adversarial discriminators, leading to unstable…

Machine Learning · Computer Science 2024-02-27 José Manuel de Frutos , Pablo M. Olmos , Manuel A. Vázquez , Joaquín Míguez

Utilization of classification latent space information for downstream reconstruction and generation is an intriguing and a relatively unexplored area. In general, discriminative representations are rich in class-specific features but are…

Though Gaussian graphical models have been widely used in many scientific fields, relatively limited progress has been made to link graph structures to external covariates. We propose a Gaussian graphical regression model, which regresses…

Methodology · Statistics 2022-02-01 Jingfei Zhang , Yi Li

Extracting insight from the enormous quantity of data generated from molecular simulations requires the identification of a small number of collective variables whose corresponding low-dimensional free-energy landscape retains the essential…

Chemical Physics · Physics 2019-12-30 Yasemin Bozkurt Varolgunes , Tristan Bereau , Joseph F. Rudzinski

Classical nonlinear dimensionality reduction (NLDR) techniques like t-SNE, Isomap, and LLE excel at creating low-dimensional embeddings for data visualization but fundamentally lack the ability to map these embeddings back to the original…

Machine Learning · Computer Science 2025-10-16 Riddhish Thakare , Kingdom Mutala Akugri

Transformer, based on the encoder-decoder framework, has achieved state-of-the-art performance on several natural language generation tasks. The encoder maps the words in the input sentence into a sequence of hidden states, which are then…

Computation and Language · Computer Science 2020-02-25 Rongxiang Weng , Haoran Wei , Shujian Huang , Heng Yu , Lidong Bing , Weihua Luo , Jiajun Chen

Generative models have emerged as powerful tools in medical imaging, enabling tasks such as segmentation, anomaly detection, and high-quality synthetic data generation. These models typically rely on learning meaningful latent…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Jordi Malé , Juan Fortea , Mateus Rozalem-Aranha , Neus Martínez-Abadías , Xavier Sevillano

While variational autoencoders have been successful in several tasks, the use of conventional priors are limited in their ability to encode the underlying structure of input data. We introduce an Encoded Prior Sliced Wasserstein AutoEncoder…

Machine Learning · Computer Science 2021-12-14 Sanjukta Krishnagopal , Jacob Bedrossian

With the recent advances in machine learning for quantum chemistry, it is now possible to predict the chemical properties of compounds and to generate novel molecules. Existing generative models mostly use a string- or graph-based…

Biomolecules · Quantitative Biology 2020-10-14 Vitali Nesterov , Mario Wieser , Volker Roth

Ordinary differential equation (ODE)-based diffusion models enable deterministic image synthesis, establishing a reversible mapping suitable for generative steganography. While prevailing methods strictly adhere to a standard normal prior,…

Cryptography and Security · Computer Science 2025-12-16 Yuhua Xu , Wei Sun , Chengpei Tang , Jiaxing Lu , Jingying Zhou , Chen Gu

We extend Gaussian perturbation models in classical functional data analysis to the three-dimensional rotational group where a zero-mean Gaussian process in the Lie algebra under the Lie exponential spreads multiplicatively around a central…

Methodology · Statistics 2024-04-19 Fabian J. E. Telschow , Stephan F. Huckemann , Michael R. Pierrynowski

Recent progress in generative compression technology has significantly improved the perceptual quality of compressed data. However, these advancements primarily focus on producing high-frequency details, often overlooking the ability of…

Computer Vision and Pattern Recognition · Computer Science 2024-03-07 Naifu Xue , Qi Mao , Zijian Wang , Yuan Zhang , Siwei Ma

Representing graph data in a low-dimensional space for subsequent tasks is the purpose of attributed graph embedding. Most existing neural network approaches learn latent representations by minimizing reconstruction errors. Rare work…

Machine Learning · Computer Science 2024-01-15 Bozhen Hu , Zelin Zang , Jun Xia , Lirong Wu , Cheng Tan , Stan Z. Li

Three-dimensional geometric data offer an excellent domain for studying representation learning and generative modeling. In this paper, we look at geometric data represented as point clouds. We introduce a deep AutoEncoder (AE) network with…

Computer Vision and Pattern Recognition · Computer Science 2018-06-13 Panos Achlioptas , Olga Diamanti , Ioannis Mitliagkas , Leonidas Guibas

Generative Adversarial Networks (GAN) are trained to generate sample images of interest distribution. To this end, generator network of GAN learns implicit distribution of real data set from the classification with candidate generated…

Machine Learning · Computer Science 2020-11-17 Gahye Lee , Seungkyu Lee

Graph Neural Networks (GNNs) and Variational Autoencoders (VAEs) have been widely used in modeling and generating graphs with latent factors. However, there is no clear explanation of what these latent factors are and why they perform well.…

Machine Learning · Computer Science 2020-11-19 Jia Li , Tomasyu Yu , Jiajin Li , Honglei Zhang , Kangfei Zhao , YU Rong , Hong Cheng , Junzhou Huang

Deep generative models have been widely used in several areas of NLP, and various techniques have been proposed to augment them or address their training challenges. In this paper, we propose a simple modification to Variational…

Machine Learning · Computer Science 2021-10-15 Lan Zhang , Wray Buntine , Ehsan Shareghi
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