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Several centimeters below the skin lie multiple biomarkers, such as glucose, oxygenation, and blood flow. Monitoring these biomarkers regularly and in a non-invasive manner would enable early insight into metabolic status and vascular…

Medical Physics · Physics 2025-10-30 Talia Xu , Caitlin Smith , Charles Lo , Jami Shepherd , Gijs van Soest , Marco Zuniga

Significance: We proposed a new design of hand-held linear-array photoacoustic (PA) probe which can acquire multi images via motor moving. Moreover, images from different locations are utilized via imaging fusion for SNR enhancement. Aim:…

Medical Physics · Physics 2020-11-09 Yongjian Zhao , Luyao Zhu , Hengrong Lan , Daohuai Jiang , Feng Gao , Fei Gao

Multispectral photoacoustic (PA) imaging is a prime modality to monitor hemodynamics and changes in blood oxygenation (sO2). Although sO2 changes can be an indicator of brain activity both in normal and in pathological conditions, PA…

Photoacoustic imaging (PAI), by combining high optical contrast with ultrasonic resolution, offers a promising noninvasive approach for dynamic monitoring of cerebral vasculature. However, transcranial PAI still faces significant challenges…

Photoacoustic (PA) imaging has the potential to revolutionize functional medical imaging in healthcare due to the valuable information on tissue physiology contained in multispectral photoacoustic measurements. Clinical translation of the…

Photoacoustic imaging (PAI) and ultrasound imaging (USI) are important biomedical imaging techniques, due to their unique and complementary advantages in tissue's structure and function visualization. In this Letter, we proposed a coaxial…

Medical Physics · Physics 2024-11-12 Yunhui Jiang , Fan Zhang , Yuwei Zheng , Ruixi Sun , Fei Gao

Photoacoustic imaging (PAI) is an emerging functional and molecular imaging technology that has attracted much attention in the past decade. Recently, many researchers have used the Vantage Verasonics research system for simultaneous…

Applied Physics · Physics 2020-12-02 Karl Kratkiewicz , Rayyan Manwar , Yang Zhou , Moein Mozaffarzadeh , Kamran Avanaki

Research in ultrasound imaging is limited in reproducibility by two factors: First, many existing ultrasound pipelines are protected by intellectual property, rendering exchange of code difficult. Second, most pipelines are implemented in…

Computer Vision and Pattern Recognition · Computer Science 2018-05-11 Rüdiger Göbl , Nassir Navab , Christoph Hennersperger

Real-time multi-spectral photoacoustic imaging (RT-mPAI) often suffers from synchronization instabilities when interfacing fast-tuning lasers with data acquisition platforms executing on non-real-time operating systems. To overcome this, we…

Hardware Architecture · Computer Science 2026-04-27 Ryo Murakami , Yichuan Tang , Haichong K. Zhang

Photoacoustic(PA) imaging is a non-destructive and non-invasive technology for visualizing minute blood vessel structures in the body using ultrasonic sensors. In PA imaging, the image quality of a single-shot image is poor, and it is…

Computer Vision and Pattern Recognition · Computer Science 2025-02-11 Tatsuhiro Eguchi , Shumpei Takezaki , Mihoko Shimano , Takayuki Yagi , Ryoma Bise

As an emerging medical diagnostic technology, photoacoustic imaging has been implemented for both preclinical and clinical applications. For clinical convenience, a handheld free scan photoacoustic tomography (PAT) system providing 3D…

Medical Physics · Physics 2022-03-18 Daohuai Jiang , Hongbo Chen , Yuting Shen , Yifan Zhang , Feng Gao , Rui Zheng , Fei Gao

Photoacoustic (PA) imaging combines the high optical absorption contrast of optical imaging with the deep tissue penetration of ultrasound detection, offering great potential for functional imaging and disease diagnosis. However, current PA…

Optics · Physics 2026-01-29 Daohuai Jiang , Xuanxuan Ye , Hengrong Lan , Xianzeng Zhang , Fei Gao

Photoacoustic imaging is an emerging technology based on the photoacoustic effect that has developed rapidly in recent years. It combines the high contrast of optical imaging and the high penetration and high resolution of acoustic imaging.…

Photoacoustic imaging (PAI) is a promising emerging imaging modality that enables spatially resolved imaging of optical tissue properties up to several centimeters deep in tissue, creating the potential for numerous exciting clinical…

Medical Physics · Physics 2021-04-15 Janek Gröhl , Melanie Schellenberg , Kris Dreher , Lena Maier-Hein

Recent advances in photoacoustic (PA) imaging have enabled detailed images of microvascular structure and quantitative measurement of blood oxygenation or perfusion. Standard reconstruction methods for PA imaging are based on solving an…

Signal Processing · Electrical Eng. & Systems 2020-04-17 MinWoo Kim , Geng-Shi Jeng , Ivan Pelivanov , Matthew O'Donnell

Photoacoustic imaging (PAI) is a powerful imaging modality that relies on the PA effect. PAI works on the principle of electromagnetic energy absorption by the exogenous contrast agents and/or endogenous molecules present in the biological…

Optics · Physics 2020-12-16 Mohsin Zafar , Qiuyun Xu , Rayyan Manwar

Photoacoustic tomography (PAT) offers high optical contrast with acoustic imaging depth, making it essential for biomedical applications. While many all-optical systems have been developed to address limitations of ultrasound transducers,…

Optics · Physics 2024-10-11 Taeil Yoon , Hakseok Ko , Jeongmyo Im , Euiheon Chung , Wonshik Choi , Byeong Ha Lee

Photoacoustic imaging (PAI) is a novel hybrid imaging technique that combines the benefits of both optical and acoustic imaging modalities, which provides functional and molecular optical contrasts of deep tissue. Commonly used ultrasound…

Medical Physics · Physics 2025-09-24 Xiyu Chen , Junxiang Cai , Rui Zheng , Tao Wu , Fei Gao

The combination of microfluidic technology and optical fluids characterization techniques has been recently applied to produce lab-on-a-chip systems. In the present work, bringing together the imaging technique called photoacoustic imaging…

Photoacoustic tomography (PAT) combines the advantages of the spectroscopic optical absorption contrast and acoustic resolution with deep penetration, and becomes an important novel biomedical imaging technology for scientific research and…

Instrumentation and Detectors · Physics 2021-12-23 Daohuai Jiang , Yifei Xu , Hengrong Lan , Feng Gao , Fei Gao
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