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Remarkable progress can be observed in recent years in the controlled emission, guiding and detection of coherent, free electrons. Those methods were applied in matter wave interferometers leading to high phase sensitivities and novel…

Instrumentation and Detectors · Physics 2017-06-28 Andreas Pooch , Michael Seidling , Moritz Layer , Alexander Rembold , Alexander Stibor

Spatial and temporal light modulation is a well-established technology that enables dynamic shaping of the phase and amplitude of optical fields, significantly enhancing the resolution and sensitivity of imaging methods. Translating this…

We introduce diffraction-based interaction-free measurements. In contrast with previous work where a set of discrete paths is engaged, good quality interaction-free measurements can be realized with a continuous set of paths, as is typical…

Quantum Physics · Physics 2020-09-04 Spencer Rogers , Yakir Aharonov , Cyril Elouard , Andrew N. Jordan

Label-free imaging of rapidly moving, sub-diffraction sized structures has important applications in both biology and material science, as it removes the limitations associated with fluorescence tagging. However, unlabeled nanoscale…

One of the astounding consequences of quantum mechanics is that it allows the detection of a target using an incident probe, with only a low probability of interaction of the probe and the target. This 'quantum weirdness' could be applied…

Atomic resolution imaging in transmission electron microscopy (TEM) and scanning TEM (STEM) of light elements in electron-transparent materials has long been a challenge. Biomolecular materials, for example, are rapidly altered when…

Instrumentation and Detectors · Physics 2018-12-05 Fehmi S. Yasin , Tyler R. Harvey , Jordan J. Chess , Jordan S. Pierce , Colin Ophus , Peter Ercius , Benjamin J. McMorran

Quantum - or classically correlated - light can be employed in various ways to improve resolution and measurement sensitivity. In an "interaction-free" measurement, a single photon can be used to reveal the presence of an object placed…

Measuring the dispersion of photonic devices with small dispersion-length products is challenging due to the phase-sensitive, and alignment-intensive nature of conventional methods. In this letter, we demonstrate a quantum technique to…

Quantum Physics · Physics 2019-09-17 Arash Riazi , Eric Y. Zhu , Changjia Chen , Alexey V. Gladyshev , Peter G. Kazansky , Li Qian

Fluorescence lifetime imaging microscopy (FLIM) is a well-established technique with numerous imaging applications. Yet, one of the limitations of FLIM is that it provides information about the emitting state only. Here, we present an…

Biological Physics · Physics 2023-10-27 Pavel Malý , Dita Strachotová , Aleš Holoubek , Petr Heřman

In this paper, we study a suitable experimental design of electrochemical impedance spectroscopy (EIS) to reduce the number of frequency points while not significantly affecting the uncertainties of the estimated cell's equivalent circuit…

Systems and Control · Electrical Eng. & Systems 2025-01-13 Vladimir Sovljanski , Mario Paolone , Sylvain Tant , Damien Pierre Sainflou

The interaction-free measurement is a fundamental quantum effect whereby the presence of a photosensitive object is determined without irreversible photon absorption. Here we propose the concept of coherent interaction-free detection and…

Quantum Physics · Physics 2023-07-10 Shruti Dogra , John J. McCord , Gheorghe Sorin Paraoanu

This paper presents for the first time an innovative instrument called an inverted scanning microwave microscope (iSMM), which is capable of noninvasive and label-free imaging and characterization of intracellular structures of a live cell…

Mid-infrared photo-induced force microscopy (IR-PiFM/PiF-IR) enables high-resolution chemical imaging of surfaces with lateral resolution less than 5 nm. Here are some answers to questions about the physical background, practical handling…

Materials Science · Physics 2026-05-05 Daniela Täuber

The highly energetic electrons in a transmission electron microscope (TEM) can alter or even completely destroy the structure of samples before sufficient information can be obtained. This is especially problematic in the case of zeolites,…

Materials Science · Physics 2021-05-05 Abner Velazco , Daen Jannis , Armand Béché , Johan Verbeeck

Understanding the fundamental limits on the precision to which an optical phase can be estimated is of key interest for many investigative techniques utilized across science and technology. We study the estimation of a fixed optical phase…

Quantum Physics · Physics 2017-12-13 Patrick M. Birchall , Jeremy L. O'Brien , Jonathan C. F. Matthews , Hugo Cable

Atomic force microscopes have proved to be fundamental research tools in many situations where a gentle imaging process is required, and in a variety of environmental conditions, such as the study of biological samples. Among the possible…

Systems and Control · Computer Science 2023-01-05 Marco Coraggio , Martin Homer , Oliver D. Payton , Mario di Bernardo

The flexible endoscope is a minimally invasive tool in clinical settings, but most of them rely on exogenous staining for diagnosis to provide qualitative information. Here, we demonstrated a flexible endoscopic microscopy (FEM) with…

The total number of electrons in a classical microplasma can be non-intrusively measured through elastic in-phase coherent microwave scattering (CMS). Here, we establish a theoretical basis for the CMS diagnostic technique with an emphasis…

An integrate-and-fire time-encoding-machine (IF-TEM) is an energy-efficient asynchronous sampler. Utilizing the IF-TEM sampler for bandlimited signals, we introduce designs for time encoding and decoding with analog compression prior to the…

Information Theory · Computer Science 2022-11-02 Saar Tarnopolsky , Hila Naaman , Yonina C. Eldar , Alejandro Cohen

Imaging mass spectrometry (IMS) is a powerful tool for untargeted, highly multiplexed molecular mapping of tissue in biomedical research. IMS offers a means of mapping the spatial distributions of molecular species in biological tissue with…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Yijie Zhang , Luzhe Huang , Nir Pillar , Yuzhu Li , Lukasz G. Migas , Raf Van de Plas , Jeffrey M. Spraggins , Aydogan Ozcan