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We introduce a reaction-path statistical mechanics formalism based on the principle of large deviations to quantify the kinetics of single-molecule enzymatic reaction processes under the Michaelis-Menten mechanism, which exemplifies an…

Statistical Mechanics · Physics 2022-04-11 Hyuntae Lim , YounJoon Jung

Computational procedures for the stationary probability distribution, the group inverse of the Markovian kernel and the mean first passage times of an irreducible Markov chain, are developed using perturbations. The derivation of these…

Probability · Mathematics 2016-10-12 Jeffrey J. Hunter

We establish a large deviation principle for the trajectories of Wiener processes subject to random resets to the origin occurring according to a Poisson process. In addition to the pathwise large deviation principle, we identify the rate…

Probability · Mathematics 2025-12-09 A. V. Logachov , O. M. Logachova , A. A. Yambartsev , K. A. Zaykov

Most biochemical reactions in living cells are open systems interacting with environment through chemostats to exchange both energy and materials. At a mesoscopic scale, the number of each species in those biochemical reactions can be…

Optimization and Control · Mathematics 2022-11-08 Yuan Gao , Jian-Guo Liu

Chemical reactions can be modeled by a random time-changed Poisson process on countable states. The macroscopic behaviors, such as large fluctuations, can be studied via the WKB reformulation. The WKB reformulation for the backward equation…

Analysis of PDEs · Mathematics 2023-06-07 Yuan Gao , Jian-Guo Liu

The movement of intracellular cargo transported by molecular motors is commonly marked by switches between directed motion and stationary pauses. The predominant measure for assessing movement is effective diffusivity, which predicts the…

Quantitative Methods · Quantitative Biology 2024-12-31 Keisha J. Cook , Nathan Rayens , Linh Do , Christine K. Payne , Scott A. McKinley

In many stochastic models, the observables of interest are naturally encoded in double transforms (e.g., Laplace transforms) that couple spatial and temporal variables. Notably, the double transform often provides the only analytically…

Probability · Mathematics 2026-05-21 Giampaolo Cristadoro , Gaia Pozzoli

The fluctuation-dissipation theorem is a central result in statistical mechanics and is usually formulated for systems described by diffusion processes. In this paper, we propose a generalization for a wider class of stochastic processes,…

Statistical Mechanics · Physics 2018-09-20 Alberto Montefusco , Mark A. Peletier , Hans Christian Öttinger

The meaning of thermodynamic descriptions is found in large-deviations scaling of the fluctuations probabilities. The primary large-deviations rate function is the entropy, which is the basis for both fluctuation theorems and for…

Statistical Mechanics · Physics 2015-05-27 Eric Smith

A large deviation principle is established for a general class of stochastic flows in the small noise limit. This result is then applied to a Bayesian formulation of an image matching problem, and an approximate maximum likelihood property…

Statistics Theory · Mathematics 2010-02-24 Amarjit Budhiraja , Paul Dupuis , Vasileios Maroulas

We consider random walk $(X_n)_{n\geq0}$ on $\mathbb{Z}^d$ in a space--time product environment $\omega\in\Omega$. We take the point of view of the particle and focus on the environment Markov chain $(T_{n,X_n}\omega)_{n\geq0}$ where $T$…

Probability · Mathematics 2011-03-08 Atilla Yilmaz

This paper studies large deviations of a ``fully coupled" finite state mean-field interacting particle system in a fast varying environment. The empirical measure of the particles evolves in the slow time scale and the random environment…

Probability · Mathematics 2021-06-24 Sarath Yasodharan , Rajesh Sundaresan

In this paper we use the theory of viscosity solutions for Hamilton-Jacobi equations to study propagation phenomena in kinetic equations. We perform the hydrodynamic limit of some kinetic models thanks to an adapted WKB ansatz. Our models…

Analysis of PDEs · Mathematics 2014-06-10 Emeric Bouin

Found all equivalence classes for electromagnetic potentials and space-time metrics of Stackel spaces, provided that the equations of motion of the classical charged test particles are integrated by the method of complete separation of…

General Relativity and Quantum Cosmology · Physics 2020-12-14 Valeriy Obukhov

We consider a continuous time Markov chain on a countable state space and prove a joint large deviation principle for the empirical measure and the empirical flow, which accounts for the total number of jumps between pairs of states. We…

Probability · Mathematics 2015-01-19 Lorenzo Bertini , Alessandra Faggionato , Davide Gabrielli

The goal of the paper is a rigorous derivation of a macroscopic traffic flow model with a bifurcation or a local perturbation from a microscopic one. The microscopic model is a simple follow-the-leader with random parameters. The random…

Analysis of PDEs · Mathematics 2021-11-16 P Cardaliaguet , N Forcadel

We study the large deviations of Markov chains under the sole assumption that the state space is discrete. In particular, we do not require any of the usual irreducibility and exponential tightness assumptions. Using subadditive arguments,…

Probability · Mathematics 2026-05-15 Léo Daures

The large deviations principle for the empirical measure for both continuous and discrete time Markov processes is well known. Various expressions are available for the rate function, but these expressions are usually as the solution to a…

Probability · Mathematics 2015-06-22 Paul Dupuis , Yufei Liu

We introduce and analyze a model for the transport of particles or energy in extended lattice systems. The dynamics of the model acts on a discrete phase space at discrete times but has nonetheless some of the characteristic properties of…

Mathematical Physics · Physics 2015-06-12 Raphael Lefevere

This paper introduces a novel methodology for the identification of switching dynamics for switched autoregressive linear models. Switching behavior is assumed to follow a Markov model. The system's outputs are contaminated by possibly…

Signal Processing · Electrical Eng. & Systems 2019-03-28 Sarah Hojjatinia , Constantino M. Lagoa