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Tau leaping is a popular method for performing fast approximate simulation of certain continuous time Markov chain models typically found in chemistry and biochemistry. This method is known to perform well when the transition rates satisfy…

Probability · Mathematics 2025-12-09 Ross McVinish , Liam Hodgkinson

Probabilistic Boolean networks (PBNs) is a widely used computational framework for modelling biological systems. The steady-state dynamics of PBNs is of special interest in the analysis of biological systems. However, obtaining the…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-09-01 Andrzej Mizera , Jun Pang , Qixia Yuan

Validating and controlling safety-critical systems in uncertain environments necessitates probabilistic reachable sets of future state evolutions. The existing methods of computing probabilistic reachable sets normally assume that…

Systems and Control · Electrical Eng. & Systems 2025-02-03 Xun Shen , Ye Wang , Kazumune Hashimoto , Yuhu Wu , Sebastien Gros

Applicability of counting statistics for a system with an infinite number of states is investigated. The counting statistics has been studied a lot for a system with a finite number of states. While it is possible to use the scheme in order…

Biological Physics · Physics 2012-09-28 Jun Ohkubo

In this paper, we propose a chance constrained stochastic model predictive control scheme for reference tracking of distributed linear time-invariant systems with additive stochastic uncertainty. The chance constraints are reformulated…

Optimization and Control · Mathematics 2023-03-07 Christoph Mark , Steven Liu

Reachability analysis has been a prominent way to provide safety guarantees for neurally controlled autonomous systems, but its direct application to neural perception components is infeasible due to imperfect or intractable perception…

Systems and Control · Electrical Eng. & Systems 2026-04-27 Yuang Geng , Thomas Waite , Trevor Turnquist , Radoslav Ivanov , Ivan Ruchkin

This paper presents an algorithm to apply nonlinear control design approaches in the case of stochastic systems with partial state observation. Deterministic nonlinear control approaches are formulated under the assumption of full state…

Systems and Control · Electrical Eng. & Systems 2023-09-19 Mohammad S. Ramadan , Mohammad Alsuwaidan , Ahmed Atallah , Sylvia Herbert

Probabilistic Logic Programming (PLP) languages enable programmers to specify systems that combine logical models with statistical knowledge. The inference problem, to determine the probability of query answers in PLP, is intractable in…

Artificial Intelligence · Computer Science 2014-03-25 Arun Nampally , C. R. Ramakrishnan

Here we develop an effective approach to simplify two-time-scale Markov chains with infinite state spaces by removal of states with fast leaving rates, which improves the simplification method of finite Markov chains. We introduce the…

Molecular Networks · Quantitative Biology 2017-09-13 Chen Jia

Motivated by applications arising in networked systems, this work examines controlled regime-switching systems that stem from a mean-variance formulation. A main point is that the switching process is a hidden Markov chain. An additional…

Optimization and Control · Mathematics 2014-01-21 Zhixin Yang , George Yin , Qing Zhang

Probabilistic programming is perfectly suited to reliable and transparent data science, as it allows the user to specify their models in a high-level language without worrying about the complexities of how to fit the models. Static analysis…

Artificial Intelligence · Computer Science 2020-08-31 Ryan Bernstein , Matthijs Vákár , Jeannette Wing

Synthetic likelihood is an attractive approach to likelihood-free inference when an approximately Gaussian summary statistic for the data, informative for inference about the parameters, is available. The synthetic likelihood method derives…

The design of biological systems is hindered by uncertainty arising from both intrinsic stochasticity of biomolecular reactions and variability across laboratory or experimental conditions. In this work, we present a sequential framework to…

Machine Learning · Computer Science 2026-05-08 Michal Kobiela , Diego A. Oyarzún , Michael U. Gutmann

This paper presents optimizations to improve the scalability of reachability analysis on a subclass of hybrid automata extended with stochasticity. The optimizations target different components of the analysis, such as quantifier…

Symbolic Computation · Computer Science 2025-10-16 Jonas Stübbe , Anne Remke , Erika Ábrahám

Stochastic branching processes are a classical model for describing random trees, which have applications in numerous fields including biology, physics, and natural language processing. In particular, they have recently been proposed to…

Logic in Computer Science · Computer Science 2012-06-07 Taolue Chen , Klaus Dräger , Stefan Kiefer

A shortcoming of existing reachability approaches for nonlinear systems is the poor scalability with the number of continuous state variables. To mitigate this problem we present a simulation-based approach where we first sample a number of…

Systems and Control · Computer Science 2017-09-21 Murat Arcak , John Maidens

The stacking problem is approached by computational mechanics, using an Ising next nearest neighbor model. Computational mechanics allows to treat the stacking arrangement as an information processing system in the light of a symbol…

Materials Science · Physics 2017-06-27 Edwin Rodriguez-Horta , Ernesto Estevez-Rams , Reinhard Neder , Raimundo Lora-Serrano

We propose a new technique for performing state space exploration of closed loop control systems with neural network feedback controllers. Our approach involves approximating the sensitivity of the trajectories of the closed loop dynamics.…

Systems and Control · Electrical Eng. & Systems 2022-07-11 Manish Goyal , Miheer Dewaskar , Parasara Sridhar Duggirala

Autonomous robots typically incorporate complex sensors in their decision-making and control loops. These sensors, such as cameras and Lidars, have imperfections in their sensing and are influenced by environmental conditions. In this…

Systems and Control · Electrical Eng. & Systems 2023-05-01 Guy Scher , Sadra Sadraddini , Russ Tedrake , Hadas Kress-Gazit

Stochastic kinetic models describe systems across biology, chemistry, and physics where discrete events and small populations render deterministic approximations inadequate. Parameter inference and inverse design in these systems require…

Computational Physics · Physics 2026-03-06 Francesco Mottes , Qian-Ze Zhu , Michael P. Brenner
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