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Methicillin-resistant Staphylococcus aureus (MRSA) is a significant contributor to the growing concern of antibiotic resistant bacteria, especially given its stubborn persistence in hospitals and other health care facility settings. In…

Populations and Evolution · Quantitative Biology 2019-11-19 Cole Butler , Jinjin Cheng , Lorena Correa , Maria Preciado-Rivas , Andres Rios-Gutierrez , Cesar Montalvo , Christopher Kribs

Diabetes is a globally prevalent disease that can cause visible microvascular complications such as diabetic retinopathy and macular edema in the human eye retina, the images of which are today used for manual disease screening. This…

Image and Video Processing · Electrical Eng. & Systems 2019-04-19 Jaakko Sahlsten , Joel Jaskari , Jyri Kivinen , Lauri Turunen , Esa Jaanio , Kustaa Hietala , Kimmo Kaski

We applied machine learning to the unmet medical need of rapid and accurate diagnosis and prognosis of acute infections and sepsis in emergency departments. Our solution consists of a Myrna (TM) Instrument and embedded TriVerity (TM)…

Raman sensing and Raman microscopy are amongst the most specific optical technologies to identify the chemical compounds of unknown samples, and to enable label-free biomedical imaging with molecular contrast. However, the high cost and…

In this paper we propose a new approach to identify melanoma diseases by identifying the distribution of its main skin chromophores (melanin, oxyhemoglobin and deoxyhemoglobin) from multispectral dermatological images. Based on Blind Source…

Medical Physics · Physics 2023-09-22 Mustapha Zokay , Hicham Saylani

Antimicrobial resistance (AMR) is a risk for patients and a burden for the healthcare system. However, AMR assays typically take several days. This study develops predictive models for AMR based on easily available clinical and…

In this project, we developed a deep learning system applied to human retina images for medical diagnostic decision support. The retina images were provided by EyePACS. These images were used in the framework of a Kaggle contest, whose…

Computer Vision and Pattern Recognition · Computer Science 2018-07-25 Maria Camila Alvarez Trivino , Jeremie Despraz , Jesus Alfonso Lopez Sotelo , Carlos Andres Pena

Stroke is a major public health problem, affecting millions worldwide. Deep learning has recently demonstrated promise for enhancing the diagnosis and risk prediction of stroke. However, existing methods rely on costly medical imaging…

Image and Video Processing · Electrical Eng. & Systems 2025-12-17 Saeed Shurrab , Aadim Nepal , Terrence J. Lee-St. John , Nicola G. Ghazi , Bartlomiej Piechowski-Jozwiak , Farah E. Shamout

Non-intrusive detection systems have the potential to characterise materials through various transparent glass and plastic containers. Food and drink adulteration is increasingly problematic, representing a serious health risk as well as an…

Instrumentation and Detectors · Physics 2020-08-20 Holly Fleming , Mingzhou Chen , Graham D. Bruce , Kishan Dholakia

Diseases are currently managed by grading systems, where patients are stratified by grading systems into stages that indicate patient risk and guide clinical management. However, these broad categories typically lack prognostic value, and…

Time-resolved spectral techniques play an important analysis tool in many contexts, from physical chemistry to biomedicine. Customarily, the label-free detection of analytes is manually performed by experts through the aid of classic…

Machine Learning · Computer Science 2020-11-17 Stefano Rini , Hirotsugu Hiramatsu

Stimulated Raman scattering (SRS) microscopy allows for high-speed label-free chemical imaging of biomedical systems. The imaging sensitivity of SRS microscopy is limited to ~10 mM for endogenous biomolecules. Electronic pre-resonant SRS…

We propose and demonstrate a novel technique that combines Raman scattering and optical cycling in molecules with diagonal Franck-Condon factors. This resonance Raman optical cycling manipulates molecules to behave like efficient…

Atomic Physics · Physics 2021-08-26 J. C. Shaw , J. C. Schnaubelt , D. J. McCarron

A Rapid and cost-effective method for detecting bacterial cells on surfaces is critical to protect public health from various aspects, including food safety, clinical hygiene, and pharmacy quality. Herein, we first established an optical…

Quantitative Methods · Quantitative Biology 2024-03-13 Yuzhen Zhang , Zili Gao , Lili He

Rapid detection of foodborne bacteria is critical for food safety and quality, yet traditional culture-based methods require extended incubation and specialized sample preparation. This study addresses these challenges by i) enhancing the…

Image and Video Processing · Electrical Eng. & Systems 2024-12-02 Siddhartha Bhattacharya , Aarham Wasit , Mason Earles , Nitin Nitin , Luyao Ma , Jiyoon Yi

From the famous 1918 H1N1 influenza to the present COVID-19 pandemic, the need for improved virial detection techniques is all too apparent. The aim of the present paper is to show that identification of individual virus particles in…

Medical Physics · Physics 2020-11-23 V. Deckert , T. Deckert-Gaudig , D. Cialla , J. Popp , R. Zell , A. V. Sokolov , Z. Yi , M. O. Scully

Strain-level identification of viruses is critical for effective public health responses to potential outbreaks, yet current diagnostic methods often lack the necessary speed or sensitivity. Surface-enhanced Raman spectroscopy (SERS) offers…

Developing rapid methods for pathogen detection and growth monitoring at low cell and analyte concentrations is an important goal, which numerous technologies are working towards solving. Rapid biosensors have already made a dramatic impact…

Rapid and reliable detection and identification of unknown chemical substances is critical to homeland security. It is challenging to identify chemical components from a wide range of explosives. There are two key steps involved. One is a…

Numerical Analysis · Mathematics 2011-10-10 Y. Sun , J. Xin

Urinary Tract Infection (UTIs) is referred as one of the most common infection in medical sectors worldwide and antimicrobial resistance (AMR) is also a global threat to human that is related with many diseases. As antibiotics used for the…

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