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Protein function prediction is a crucial task in bioinformatics, with significant implications for understanding biological processes and disease mechanisms. While the relationship between sequence and function has been extensively…

Quantitative Methods · Quantitative Biology 2024-09-04 Shania Mitra , Lei Huang , Manolis Kellis

The support vector machine algorithm with a quantum kernel estimator (QSVM-Kernel), as a leading example of a quantum machine learning technique, has undergone significant advancements. Nevertheless, its integration with classical data…

Machine Learning · Computer Science 2024-07-22 Emine Akpinar , Sardar M. N. Islam , Murat Oduncuoglu

Recent advances in genomic sequencing technology have resulted in an abundance of genome sequence data. Despite the progress in interpreting those data, there remains a broad scope for their translation into clinical and societal benefits.…

Genomics · Quantitative Biology 2021-12-13 Abhinav Jain , Greg Slabaugh , Deepti Gurdasani

Based on the BioBricks standard, restriction synthesis is a novel catabolic iterative DNA synthesis method that utilizes endonucleases to synthesize a query sequence from a reference sequence. In this work, the reference sequence is built…

Signal Processing · Electrical Eng. & Systems 2020-12-14 Ethan J. Moyer , Anup Das

Medical data classification is typically a challenging task due to imbalance between classes. In this paper, we propose an approach to classify dermatoscopic images from HAM10000 (Human Against Machine with 10000 training images) dataset,…

Image and Video Processing · Electrical Eng. & Systems 2021-11-05 Priscilla Benedetti , Damiano Perri , Marco Simonetti , Osvaldo Gervasi , Gianluca Reali , Mauro Femminella

The aim of this work is to propose an ensemble of descriptors for Melanoma Classification, whose performance has been evaluated on validation and test datasets of the melanoma challenge 2018. The system proposed here achieves a strong…

Computer Vision and Pattern Recognition · Computer Science 2018-07-24 Loris Nanni , Alessandra Lumini , Stefano Ghidoni

Neoplasms (NPs) and neurological diseases and disorders (NDDs) are amongst the major classes of diseases underlying deaths of a disproportionate number of people worldwide. To determine if there exist some distinctive features in the local…

Molecular Networks · Quantitative Biology 2022-12-27 Vikram Singh , Vikram Singh

Recent advances in experimental methods have enabled researchers to collect data on thousands of analytes simultaneously. This has led to correlational studies that associated molecular measurements with diseases such as Alzheimer's, Liver,…

Quantitative Methods · Quantitative Biology 2024-05-20 Divyagna Bavikadi , Ayushi Agarwal , Shashank Ganta , Yunro Chung , Lusheng Song , Ji Qiu , Paulo Shakarian

Liquid chromatography with tandem mass spectrometry (LC-MS/MS) based proteomics is a well-established research field with major applications such as identification of disease biomarkers, drug discovery, drug design and development. In…

Quantitative Methods · Quantitative Biology 2018-01-08 Fatema Tuz Zohora , Ngoc Hieu Tran , Xianglilan Zhang , Lei Xin , Baozhen Shan , Ming Li

Automated protein function prediction is a challenging problem with distinctive features, such as the hierarchical organization of protein functions and the scarcity of annotated proteins for most biological functions. We propose a…

Machine Learning · Statistics 2019-04-09 Marco Frasca , Nicolò Cesa Bianchi

Fruit recognition using Deep Convolutional Neural Network (CNN) is one of the most promising applications in computer vision. In recent times, deep learning based classifications are making it possible to recognize fruits from images.…

Computer Vision and Pattern Recognition · Computer Science 2020-01-28 Shadman Sakib , Zahidun Ashrafi , Md. Abu Bakr Siddique

Predicting protein properties such as solvent accessibility and secondary structure from its primary amino acid sequence is an important task in bioinformatics. Recently, a few deep learning models have surpassed the traditional window…

Machine Learning · Computer Science 2016-05-11 Zeming Lin , Jack Lanchantin , Yanjun Qi

Breast cancer is a highly heterogeneous disease with diverse molecular profiles. The PAM50 gene signature is widely recognized as a standard for classifying breast cancer into intrinsic subtypes, enabling more personalized treatment…

Prediction of protein secondary structure from the amino acid sequence is a classical bioinformatics problem. Common methods use feed forward neural networks or SVMs combined with a sliding window, as these models does not naturally handle…

Quantitative Methods · Quantitative Biology 2015-01-06 Søren Kaae Sønderby , Ole Winther

Prediction of one-dimensional protein structures such as secondary structures and contact numbers is useful for the three-dimensional structure prediction and important for the understanding of sequence-structure relationship. Here we…

Biomolecules · Quantitative Biology 2007-05-23 Akira R. Kinjo , Ken Nishikawa

Propensity Score Matching (PSM) is a causal inference technique that is used as a substitution for experimental methods when it is not possible to implement them due to logistical and ethical concerns. By using a logistic classifier to…

Applications · Statistics 2025-01-15 Elizabeth Mohney , Alexey Shvets

Protein dynamics play a crucial role in many biological processes and drug interactions. However, measuring, and simulating protein dynamics is challenging and time-consuming. While machine learning holds promise in deciphering the…

Machine Learning · Computer Science 2024-08-23 Sina Sarparast , Aldo Zaimi , Maximilian Ebert , Michael-Rock Goldsmith

Link prediction is an important task in social network analysis. There are different characteristics (features) in a social network that can be used for link prediction. In this paper, we evaluate the effectiveness of aggregated features…

Social and Information Networks · Computer Science 2020-07-01 Mohammad G. Raeini

We investigate star-galaxy classification for astronomical surveys in the context of four methods enabling the interpretation of black-box machine learning systems. The first is outputting and exploring the decision boundaries as given by…

Instrumentation and Methods for Astrophysics · Physics 2018-09-26 Xan Morice-Atkinson , Ben Hoyle , David Bacon

While many good textbooks are available on Protein Structure, Molecular Simulations, Thermodynamics and Bioinformatics methods in general, there is no good introductory level book for the field of Structural Bioinformatics. This book aims…