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Electronic Health Records (EHRs) hold immense potential for advancing healthcare, offering rich, longitudinal data that combines structured information with valuable insights from unstructured clinical notes. However, the unstructured…
The primary analysis of clinical trials in diabetes therapeutic area often involves a mixed-model repeated measure (MMRM) approach to estimate the average treatment effect for longitudinal continuous outcome, and a generalized linear mixed…
This paper presents a weighted optimization framework that unifies the binary,multi-valued, continuous, as well as mixture of discrete and continuous treatment, under the unconfounded treatment assignment. With a general loss function, the…
It is a common practice in randomized clinical trials with the standard survival outcome to follow patients until a prespecified number of events have been observed, a type of trial known as the event-driven trial. The event-driven design…
The concept of care pathways is increasingly being used to enhance the quality of care and to optimize the use of resources for health care. Nevertheless, recommendations regarding the sequence of care are mostly based on consensus-based…
Background: As empirical software engineering evolves, more studies adopt data strategies$-$approaches that investigate digital artifacts such as models, source code, or system logs rather than relying on human subjects. Synthesizing…
Recently, there has been great interest in estimating the conditional average treatment effect using flexible machine learning methods. However, in practice, investigators often have working hypotheses about effect heterogeneity across…
In causal inference, a variety of causal effect estimands have been studied, including the sample, uncensored, target, conditional, optimal subpopulation, and optimal weighted average treatment effects. Ad-hoc methods have been developed…
Increasing the success rate of a process, i.e. the percentage of cases that end in a positive outcome, is a recurrent process improvement goal. At runtime, there are often certain actions (a.k.a. treatments) that workers may execute to lift…
Event simulation for electron neutrino interactions plays a foundational role in precision measurements in particle physics experiments, yet the computational demand of traditional Monte Carlo methods remains a significant challenge,…
There has been a lot of recent interest in mining patterns from graphs. Often, the exact structure of the patterns of interest is not known. This happens, for example, when molecular structures are mined to discover fragments useful as…
In recent decades, event studies have emerged as a central methodology in health and social research for evaluating the causal effects of staggered interventions. In this paper, we analyze event studies from experimental design principles…
Sequential effect systems are a class of effect system that exploits information about program order, rather than discarding it as traditional commutative effect systems do. This extra expressive power allows effect systems to reason about…
Process models may be automatically generated from event logs that contain as-is data of a business process. While such models generalize over the control-flow of specific, recorded process executions, they are often also annotated with…
Complex software systems evolve frequently, e.g., when introducing new features or fixing bugs during maintenance. However, understanding the impact of such changes on system behavior is often difficult. Many approaches have thus been…
Although understanding and characterizing causal effects have become essential in observational studies, it is challenging when the confounders are high-dimensional. In this article, we develop a general framework $\textit{CausalEGM}$ for…
We develop the "generalized consistent weighted sampling" (GCWS) for hashing the "powered-GMM" (pGMM) kernel (with a tuning parameter $p$). It turns out that GCWS provides a numerically stable scheme for applying power transformation on the…
Resolution of complex post-production issues in large-scale open-source software (OSS) projects requires significant cognitive effort, as developers need to go through long, unstructured and fragmented issue discussion threads before that.…
Event extraction is challenging due to the complex structure of event records and the semantic gap between text and event. Traditional methods usually extract event records by decomposing the complex structure prediction task into multiple…
Context: Forgetting is defined as a gradual process of losing information. Even though there are many studies demonstrating the effect of forgetting in software development, to the best of our knowledge, no study explores the impact of…