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We discuss a theoretical approach that employs machine learning potential energy surfaces (ML-PESs) in the nonadiabatic dynamics simulation of polyatomic systems by taking 6-aminopyrimidine as a typical example. The Zhu-Nakamura theory is…

Chemical Physics · Physics 2018-05-11 Deping Hu , Yu Xie , Xusong Li , Lingyue Li , Zhenggang Lan

The study of chemical reactions in aqueous media is very important for its implications in several fields of science, from biology to industrial processes. Modelling these reactions is however difficult when water directly participates in…

Chemical Physics · Physics 2021-03-24 Manyi Yang , Luigi Bonati , Daniela Polino , Michele Parrinello

In recent years, machine learning (ML) methods have become increasingly popular in computational chemistry. After being trained on appropriate ab initio reference data, these methods allow to accurately predict the properties of chemical…

Chemical Physics · Physics 2019-09-25 Oliver T. Unke , Markus Meuwly

Partial differential equations (PDEs) form the backbone of simulations of many natural phenomena, for example in climate modeling, material science, and even financial markets. The application of physics-informed neural networks to…

Quantum Physics · Physics 2026-04-17 Nils Klement , Veronika Eyring , Mierk Schwabe

Molecular sciences address a wide range of problems involving molecules of different types and sizes and their complexes. Recently, geometric deep learning, especially Graph Neural Networks, has shown promising performance in molecular…

Machine Learning · Computer Science 2023-11-21 Shuo Zhang , Yang Liu , Lei Xie

We propose a mask pretraining method for Graph Neural Networks (GNNs) to improve their performance on fitting potential energy surfaces, particularly in water systems. GNNs are pretrained by recovering spatial information related to…

Machine Learning · Computer Science 2024-06-21 Zehua Zhang , Zijie Li , Amir Barati Farimani

Recent advances in applying Graph Neural Networks (GNNs) to molecular science have showcased the power of learning three-dimensional (3D) structure representations with GNNs. However, most existing GNNs suffer from the limitations of…

Biomolecules · Quantitative Biology 2023-11-21 Shuo Zhang , Yang Liu , Lei Xie

Chemical kinetics and reaction engineering consists of the phenomenological framework for the disentanglement of reaction mechanisms, optimization of reaction performance and the rational design of chemical processes. Here, we utilize…

Machine Learning · Computer Science 2021-12-10 Gabriel S. Gusmão , Adhika P. Retnanto , Shashwati C. da Cunha , Andrew J. Medford

Due to the development of efficient algorithms and the improvement of computer power it is now possible to map out potential energy surfaces (PES) of reactions at surfaces in great detail. This achievement has been accompanied by an…

Condensed Matter · Physics 2007-05-23 Axel Gross

Molecular mechanics (MM) potentials have long been a workhorse of computational chemistry. Leveraging accuracy and speed, these functional forms find use in a wide variety of applications in biomolecular modeling and drug discovery, from…

Nonlinear physical phenomena often show complex multiscale interactions; motivated by the principles of multiscale modeling in scientific computing, we propose PAS-Net, a physics-informed Adaptive-Scale Deep Operator Network for learning…

Computational Physics · Physics 2025-11-20 Changhong Mou , Yeyu Zhang , Xuewen Zhu , Qiao Zhuang

This study presents two different machine learning approaches for the modeling of hydrodynamic force on particles in a particle-laden multiphase flow. Results from particle-resolved direct numerical simulations (PR-DNS) of flow over a…

Fluid Dynamics · Physics 2020-07-15 S. Balachandar , W. C. Moore , G. Akiki , K. Liu

The graph neural network (GNN) has been a powerful deep-learning tool in chemistry domain, due to its close connection with molecular graphs. Most GNN models collect and update atom and molecule features from the fed atom (and, in some…

Chemical Physics · Physics 2022-03-18 Yeji Kim , Yoonho Jeong , Jihoo Kim , Eok Kyun Lee , Won June Kim , Insung S. Choi

We present an isotropic ab initio (para-H$_2$)$_4$ four-body interaction potential energy surface (PES). The electronic structure calculations are performed at the correlated coupled-cluster theory level, with single, double, and…

Chemical Physics · Physics 2025-06-09 Alexander Ibrahim , Pierre-Nicholas Roy

The accurate prediction of small scales in underresolved flows is still one of the main challenges in predictive simulations of complex configurations. Over the last few years, data-driven modeling has become popular in many fields as…

Fluid Dynamics · Physics 2022-10-31 Mathis Bode

Two-dimensional electronic spectroscopy (2DES) has enabled significant discoveries in both biological and synthetic energy-transducing systems. Although deriving chemical information from 2DES is a complex task, machine learning (ML) offers…

Chemical Physics · Physics 2025-03-21 Jonathan D. Schultz , Kelsey A. Parker , Bashir Sbaiti , David N. Beratan

Numerical solution of partial differential equations (PDEs) plays a vital role in various fields of science and engineering. In recent years, deep neural networks (DNNs) have emerged as a powerful tool for solving PDEs, leveraging their…

Numerical Analysis · Mathematics 2026-02-16 Shuo Ling , Wenjun Ying , Zhen Zhang

Reflecting the increasing interest in quantum computing, the variational quantum eigensolver (VQE) has attracted much attentions as a possible application of near-term quantum computers. Although the VQE has often been applied to quantum…

Quantum Physics · Physics 2022-12-07 Yasutaka Nishida , Fumihiko Aiga

Physics Informed Machine Learning has emerged as a popular approach for modeling and simulation in digital twins, enabling the generation of accurate models of processes and behaviors in real-world systems. However, existing methods either…

Machine Learning · Computer Science 2025-07-15 Muhammad Saad Zia , Ashiq Anjum , Lu Liu , Anthony Conway , Anasol Pena Rios

A central concern of molecular dynamics simulations are the potential energy surfaces that govern atomic interactions. These hypersurfaces define the potential energy of the system, and have generally been calculated using either predefined…

Computational Physics · Physics 2019-07-05 Emir Kocer , Jeremy K. Mason , Hakan Erturk