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A variety of enhanced sampling methods predict multidimensional free energy landscapes associated with biological and other molecular processes as a function of a few selected collective variables (CVs). The accuracy of these methods is…

Computational Physics · Physics 2024-04-09 Lukas Müllender , Andrea Rizzi , Michele Parrinello , Paolo Carloni , Davide Mandelli

Collaborative filtering (CF) and content-based filtering (CBF) have widely been used in information filtering applications. Both approaches have their strengths and weaknesses which is why researchers have developed hybrid systems. This…

Machine Learning · Computer Science 2012-12-12 Kai Yu , Anton Schwaighofer , Volker Tresp , Wei-Ying Ma , HongJiang Zhang

Atypical, rare trajectories of dynamical systems are important: they are often the paths for chemical reactions, the haven of (relative) stability of planetary systems, the rogue waves that are detected in oil platforms, the structures that…

Statistical Mechanics · Physics 2012-04-12 Cristian Giardina , Jorge Kurchan , Vivien Lecomte , Julien Tailleur

Recent learning-based methods for event-based optical flow estimation utilize cost volumes for pixel matching but suffer from redundant computations and limited scalability to higher resolutions for flow refinement. In this work, we take…

Computer Vision and Pattern Recognition · Computer Science 2025-06-23 Daikun Liu , Lei Cheng , Teng Wang , changyin Sun

Collective variables (CVs) are low-dimensional projections of high-dimensional system states. They are used to gain insights into complex emergent dynamical behaviors of processes on networks. The relation between CVs and network measures…

Physics and Society · Physics 2026-03-19 Marvin Lücke , Stefanie Winkelmann , Jobst Heitzig , Nora Molkenthin , Péter Koltai

Two fundamental problems in unsupervised learning are efficient inference for latent-variable models and robust density estimation based on large amounts of unlabeled data. Algorithms for the two tasks, such as normalizing flows and…

Machine Learning · Statistics 2018-08-02 Changyou Chen , Chunyuan Li , Liqun Chen , Wenlin Wang , Yunchen Pu , Lawrence Carin

We present a novel sampling-based method for estimating probabilities of rare or failure events. Our approach is founded on the Ensemble Kalman filter (EnKF) for inverse problems. Therefore, we reformulate the rare event problem as an…

Numerical Analysis · Mathematics 2021-12-15 Fabian Wagner , Iason Papaioannou , Elisabeth Ullmann

The phenomenon of solidification of a substance from its liquid phase is of the greatest practical and theoretical importance, and atomistic simulations can provide precious information towards its understanding and control. Unfortunately,…

Soft Condensed Matter · Physics 2021-03-25 Tarak Karmakar , Michele Invernizzi , Valerio Rizzi , Michele Parrinello

Investigating processes in complex molecular systems, which are characterized by many variables, is a crucial problem in computational physics. These systems can be reduced to a few meaningful degrees of freedom known as collective…

Chemical Physics · Physics 2024-05-27 Tuğçe Gökdemir , Jakub Rydzewski

In this paper, we introduce a new algorithm for rare event estimation based on adaptive importance sampling. We consider a smoothed version of the optimal importance sampling density, which is approximated by an ensemble of interacting…

Computation · Statistics 2023-04-19 Konstantin Althaus , Iason Papaioannou , Elisabeth Ullmann

We introduce a novel enhanced sampling approach named OPES flooding for calculating the kinetics of rare events from atomistic molecular dynamics simulation. This method is derived from the On-the-fly-Probability-Enhanced-Sampling (OPES)…

Chemical Physics · Physics 2022-10-31 Dhiman Ray , Narjes Ansari , Valerio Rizzi , Michele Invernizzi , Michele Parrinello

Chance constraints provide a principled framework to mitigate the risk of high-impact extreme events by modifying the controllable properties of a system. The low probability and rare occurrence of such events, however, impose severe…

Optimization and Control · Mathematics 2022-01-11 Shanyin Tong , Anirudh Subramanyam , Vishwas Rao

In order to prevent velocity, pressure, and temperature spikes at material discontinuities occurring when the interface-capturing schemes inconsistently simulate compressible multi-material flows(when the specific heats ratio is…

Computational Physics · Physics 2020-12-29 Zhiwei He , Yousheng Zhang , Li Li , Baolin Tian

Normalizing flows model a complex target distribution in terms of a bijective transform operating on a simple base distribution. As such, they enable tractable computation of a number of important statistical quantities, particularly…

Machine Learning · Computer Science 2022-09-01 Chandramouli Shama Sastry , Andreas Lehrmann , Marcus Brubaker , Alexander Radovic

Continuous Normalizing Flows (CNFs) enable elegant generative modeling but remain bottlenecked by slow sampling: producing a single sample requires solving a nonlinear ODE with hundreds of function evaluations. Recent approaches such as…

Machine Learning · Computer Science 2025-10-23 Erkan Turan , Aristotelis Siozopoulos , Louis Martinez , Julien Gaubil , Emery Pierson , Maks Ovsjanikov

Rare events in molecular dynamics are often related to noise-induced transitions between different macroscopic states (e.g., in protein folding). A common feature of these rare transitions is that they happen on timescales that are on…

Probability · Mathematics 2026-01-06 Carsten Hartmann , Annika Jöster , Christof Schütte , Alexander Sikorski , Marcus Weber

Classical Computational Fluid Dynamics (CFD) of long-time processes with strongly separated time scales is computationally extremely demanding if not impossible. Consequently, the state-of-the-art description of such systems is not capable…

Fluid Dynamics · Physics 2016-08-08 Thomas Lichtenegger , Stefan Pirker

We introduce a new paradigm for generative modeling built on Continuous Normalizing Flows (CNFs), allowing us to train CNFs at unprecedented scale. Specifically, we present the notion of Flow Matching (FM), a simulation-free approach for…

Machine Learning · Computer Science 2023-02-09 Yaron Lipman , Ricky T. Q. Chen , Heli Ben-Hamu , Maximilian Nickel , Matt Le

Classical continuum-based liquid vapour phase-change models typically assume continuity of temperature at phase interfaces along with a relation which describes the rate of evaporation at the interface (Hertz-Knudsen-Schrage, for example).…

Fluid Dynamics · Physics 2021-06-10 Anirudh S Rana , Sonu Saini , Suman Chakraborty , Duncan A Lockerby , James E Sprittles

Spatial and temporal stream model has gained great success in video action recognition. Most existing works pay more attention to designing effective features fusion methods, which train the two-stream model in a separate way. However, it's…

Computer Vision and Pattern Recognition · Computer Science 2019-08-28 Jingran Zhang , Fumin Shen , Xing Xu , Heng Tao Shen