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A prominent model for transportation networks is branched transport, which seeks the optimal transportation scheme to move material from a given initial to a final distribution. The cost of the scheme encodes a higher transport efficiency…

Classical Analysis and ODEs · Mathematics 2020-09-04 Alessio Brancolini , Benedikt Wirth

We study transport in synthetic, bi-disperse porous structures, with arrays of microchannels interconnected by a nanoporous layer. These structures are inspired by the xylem tissue in vascular plants, in which sap water travels from the…

Soft Condensed Matter · Physics 2024-07-23 Olivier Vincent , Théo Tassin , Erik J. Huber , Abraham D. Stroock

Scientists have long sought to understand how vascular networks supply blood and oxygen to cells throughout the body. Recent work focuses on principles that constrain how vessel size changes through branching generations from the aorta to…

Tissues and Organs · Quantitative Biology 2015-09-10 Mitchell G Newberry , Daniel B Ennis , Van M Savage

Banded patterns consisting of alternating bare soil and dense vegetation have been observed in water-limited ecosystems across the globe, often appearing along gently sloped terrain with the stripes aligned transverse to the elevation…

Pattern Formation and Solitons · Physics 2023-06-16 Punit Gandhi , Lucien Werner , Sarah Iams , Karna Gowda , Mary Silber

Cell polarity and movement are fundamental to many biological functions. Experimental and theoretically studies have indicated that interactions of certain proteins lead to the cell polarization which plays a key role in controlling the…

Dynamical Systems · Mathematics 2022-08-12 Shuang Liu , Li-Tien Cheng , Bo Li

The interface dynamics of a 3D cell immersed in a 3D extracellular matrix is investigated. We suggest a 3D generalization of a known 2D minimal phase field model suggested in [1] for the description of keratocyte motility. Our model…

Biological Physics · Physics 2021-06-04 Mohammad Abu Hamed , Alexander A. Nepomnyashchy

We present a two channel driven lattice gas model with oppositely directed species moving on two parallel lanes with lane switching processes. We study correlated lane switching mechanism for particles so that switching may occur with…

Statistical Mechanics · Physics 2015-05-28 Sudipto Muhuri , Ignacio Pagonabarraga

Life and functioning of higher organisms depends on the continuous supply of metabolites to tissues and organs. What are the requirements on the transport network pervading a tissue to provide a uniform supply of nutrients, minerals, or…

Biological Physics · Physics 2018-07-09 Felix J. Meigel , Karen Alim

We derive a reduced model of solute transport in blood based on the center manifold theory. The derivation is carried out on a convection diffusion equation with general axial and radial velocity profiles in a blood vessel of varying cross…

Fluid Dynamics · Physics 2019-12-23 Rami Masri , Charles Puelz , Beatrice Riviere

During migration cells exhibit a rich variety of seemingly random migration patterns, which makes unraveling the underlying mechanisms that control cell migration a daunting challenge. For efficient migration cells require a mechanism for…

Biological Physics · Physics 2020-08-19 Jonathan E. Ron , Pascale Monzo , Nils Gauthier , Raphael Voituriez , Nir S. Gov

We are surrounded by spatio-temporal patterns resulting from the interaction of the numerous basic units constituting natural or human-made systems. In presence of diffusive-like coupling, Turing theory has been largely applied to explain…

Pattern Formation and Solitons · Physics 2025-09-15 Marie Dorchain , S. Nirmala Jenifer , Timoteo Carletti

Extended systems driven through strong disorder are modeled generically using coarse-grained degrees of freedom that interact elastically in the directions parallel to the driving force and that slip along at least one of the directions…

Disordered Systems and Neural Networks · Physics 2007-05-23 M. Cristina Marchetti , A. Alan Middleton , Karl Saunders , J. M. Schwarz

A model for the unidirectional movement of dynein is presented based on structural observations and biochemical experimental results available. In this model, the binding affinity of dynein for microtubule is independent of its nucleotide…

Biomolecules · Quantitative Biology 2007-08-18 Ping Xie , Shuo-Xing Dou , Peng-Ye Wang

This work presents the development, analysis and numerical simulations of a biophysical model for 3D cell deformation and movement, which couples biochemical reactions and biomechanical forces. We propose a mechanobiochemical model which…

Cell Behavior · Quantitative Biology 2019-03-25 Laura Murphy , Anotida Madzvamuse

Traffic-like collective movements are observed at almost all levels of biological systems. Molecular motor proteins like, for example, kinesin and dynein, which are the vehicles of almost all intra-cellular transport in eukayotic cells,…

Biological Physics · Physics 2009-11-11 Debashish Chowdhury , Andreas Schadschneider , Katsuhiro Nishinari

In this paper, we introduce an ASEP-like transport model for bidirectional motion of particles on a multi-lane lattice. The model is motivated by {\em in vivo} experiments on organelle motility along a microtubule (MT), consisting of…

Cellular Automata and Lattice Gases · Physics 2015-05-28 Congping Lin , Gero Steinberg , Peter Ashwin

We perform an analytical investigation of the cell interface dynamics in the framework of a minimal phase field model of cell motility suggested in [1], which consists of two coupled evolution equations for the order parameter and a…

Biological Physics · Physics 2019-10-04 Mohammad Abu Hamed , Alexander A. Nepomnyashchy

The transport of macromolecules, such as DNA, through the cytoskeleton is critical to wide-ranging cellular processes from cytoplasmic streaming to transcription. The rigidity and steric hindrances imparted by the network of filaments…

We harness the physics-informed neural network (PINN) approach to extend the utility of phenomenological models for particle migration in shear flow. Specifically, we propose to constrain the neural network training via a model for the…

Fluid Dynamics · Physics 2023-04-28 Daihui Lu , Ivan C. Christov

A one-dimensional cross-diffusion system modeling the transport of vesicles in neurites is analyzed. The equations are coupled via nonlinear Robin boundary conditions to ordinary differential equations for the number of vesicles in the…

Analysis of PDEs · Mathematics 2023-05-25 Markus Fellner , Ansgar Jüngel