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This paper presents a comprehensive software stack architecture for integrating quantum computing (QC) capabilities with High-Performance Computing (HPC) environments. While quantum computers show promise as specialized accelerators for…

An accurate description of strong correlation is quintessential for the exploration of emerging chemical phenomena. While near-term variational quantum algorithms provide a theoretically scalable framework for quantum chemical problems, the…

Quantum Physics · Physics 2025-10-20 Arpan Choudhury , Sonaldeep Halder , Rahul Maitra , Debashree Ghosh

Quantum Computing (QC) offers significant potential to enhance scientific discovery in fields such as quantum chemistry, optimization, and artificial intelligence. Yet QC faces challenges due to the noisy intermediate-scale quantum era's…

Quantum computing has made substantial progress in recent years; however, its scalability remains constrained on a monolithic quantum processing unit (QPU). Distributed quantum computing (DQC) offers a pathway by coordinating multiple QPUs…

Emerging Technologies · Computer Science 2025-11-26 Sen Zhang , Lingjun Xiong , Yipie Liu , Brian L. Mark , Lei Yang , Zebo Yang , Weiwen Jiang

Demonstrating quantum advantage has been a pressing challenge in the field. Most claimed quantum speedups rely on a subroutine in which classical information can be accessed in a coherent quantum manner, which imposes a crucial constraint…

Quantum Physics · Physics 2025-11-04 Nhat A. Nghiem

The practical application of quantum technologies to chemical problems faces significant challenges, particularly in the treatment of realistic basis sets and the accurate inclusion of electron correlation effects. A direct approach to…

To address the growing needs for scalable High Performance Computing (HPC) and Quantum Computing (QC) integration, we present our HPC-QC full stack framework and its hybrid workload development capability with modular…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-10-24 Xin Zhan , K. Grace Johnson , Aniello Esposito , Barbara Chapman , Marco Fiorentino , Kirk M. Bresniker , Raymond G. Beausoleil , Masoud Mohseni

Quantum computing promises to revolutionize several scientific and technological domains through fundamentally new ways of processing information. Among its most compelling applications is digital quantum simulation, where quantum computers…

Quantum Physics · Physics 2026-02-05 Laurin E. Fischer

Scaling the size of monolithic quantum computer systems is a difficult task. As the number of qubits within a device increases, a number of factors contribute to decreases in yield and performance. To meet this challenge, distributed…

Clustering multi-dimensional points is a fundamental task in many fields, and density-based clustering supports many applications as it can discover clusters of arbitrary shapes. This paper addresses the problem of Density-Peaks Clustering…

Databases · Computer Science 2022-12-01 Daichi Amagata , Takahiro Hara

We define some of the programming and system-level challenges facing the application of quantum processing to high-performance computing. Alongside barriers to physical integration, prominent differences in the execution of quantum and…

Quantum Physics · Physics 2017-12-06 Keith A. Britt , Fahd A. Mohiyaddin , Travis S. Humble

Deep Neural Networks (DNNs) have been widely deployed for many Machine Learning applications. Recently, CapsuleNets have overtaken traditional DNNs, because of their improved generalization ability due to the multi-dimensional capsules, in…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-01-26 Alberto Marchisio , Muhammad Abdullah Hanif , Muhammad Shafique

Programming modern high-performance computing systems is challenging due to the need to efficiently program GPUs and accelerators and to handle data movement between nodes. The C++ language has been continuously enhanced in recent years…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-05-12 Biagio Cosenza , Lorenzo Carpentieri , Kaijie Fan , Marco D'Antonio , Peter Thoman , Philip Salzmann

Quantum computers hold immense potential in the field of chemistry, ushering new frontiers to solve complex many body problems that are beyond the reach of classical computers. However, noise in the current quantum hardware limits their…

Quantum Physics · Physics 2024-03-20 Chayan Patra , Sonaldeep Halder , Rahul Maitra

Quantum Computing (QC) offers the potential to enhance traditional High-Performance Computing (HPC) workloads by leveraging the unique properties of quantum computers, leading to the emergence of a new paradigm: HPC-QC. While this…

We propose and experimentally demonstrate sequential quantum computing (SQC), a paradigm that utilizes multiple homogeneous or heterogeneous quantum processors in hybrid classical-quantum workflows. In this manner, we are able to overcome…

Entanglement is widely believed to lie at the heart of the advantages offered by a quantum computer. This belief is supported by the discovery that a noiseless (pure) state quantum computer must generate a large amount of entanglement in…

Quantum Physics · Physics 2008-11-16 B. P. Lanyon , M. Barbieri , M. P. Almeida , A. G. White

Distributed quantum computing (DQC) is a promising technique for scaling up quantum systems. While significant progress has been made in DQC for quantum circuit models, there exists much less research on DQC for measurement-based quantum…

Quantum Physics · Physics 2026-01-05 Yecheng Xue , Rui Yang , Zhiding Liang , Tongyang Li

The Coupled Cluster (CC) method is used to compute the electronic correlation energy in atoms and molecules and often leads to highly accurate results. However, due to its single-reference nature, standard CC in its projected form fails to…

Achieving high-performance computation on quantum systems presents a formidable challenge that necessitates bridging the capabilities between quantum hardware and classical computing resources. This study introduces an innovative…

Quantum Physics · Physics 2024-03-19 Kuan-Cheng Chen , Xiaoren Li , Xiaotian Xu , Yun-Yuan Wang , Chen-Yu Liu