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Related papers: The Thermodynamic Uncertainty Relation in Biochemi…

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Recent measurements of durations of non-equilibrium processes provide valuable information on microscopic mechanisms and energetics. Comprehensive theory for corresponding experiments so far is well developed for single-particle systems…

Statistical Mechanics · Physics 2020-09-04 David Voráč , Philipp Maass , Artem Ryabov

Traditionally, it is understood that fluctuations in the equilibrium distribution are not evident in thermodynamic systems of large $N$ (the number of particles in the system) \cite{Huang1}. In this paper we examine the validity of this…

Mathematical Physics · Physics 2007-10-03 Kieran Kelly , Przemysław Repetowicz , Seosamh macRéamoinn

Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function. Here, we…

Tissues and Organs · Quantitative Biology 2023-01-26 Lingyun Xiong , Alan Garfinkel

The past twenty years have seen a resurgence of interest in nonequilibrium thermodynamics, thanks to advances in the theory of stochastic processes and in their thermodynamic interpretation. Fluctuation theorems provide fundamental…

Statistical Mechanics · Physics 2017-11-16 Robert Marsland , Jeremy England

The thermodynamic uncertainty relation offers a universal energetic constraint on the relative magnitude of current fluctuations in nonequilibrium steady states. However, it has only been derived for long observation times. Here, we prove a…

Statistical Mechanics · Physics 2017-08-30 Jordan M. Horowitz , Todd R. Gingrich

Thermodynamic uncertainty relations (TURs) are a set of inequalities expressing a fundamental trade-off between precision and dissipation in non-equilibrium classical and quantum thermodynamic processes. TURs show that achieving low…

Quantum Physics · Physics 2025-03-07 Mario Motta , Antonio Mezzacapo , Giacomo Guarnieri

For fluctuating currents in non-equilibrium steady states, the recently discovered thermodynamic uncertainty relation expresses a fundamental relation between their variance and the overall entropic cost associated with the driving. We show…

Statistical Mechanics · Physics 2017-07-12 Patrick Pietzonka , Felix Ritort , Udo Seifert

The circadian clock is the molecular mechanism responsible for the adaptation to daily rhythms in living organisms. Oscillations and fluctuations in environmental conditions regulate the circadian clock through signaling pathways. We study…

Biological Physics · Physics 2019-03-26 Andrea Auconi , Patrick Pett , Edda Klipp , Hanspeter Herzel

We investigate an optomechanical system as a model of an autonomous mechanical pendulum clock in the quantum regime, whose operation relies only on incoherent (thermal) resources. The escapement of the clock, the mechanism that translates…

Quantum Physics · Physics 2026-05-19 Matteo Brunelli , Mohammad Mehboudi , Nicolas Brunner , Patrick P. Potts

Biomolecules carry out very specialized tasks inside the cell where energies involved are few tens of k_BT, small enough for thermal fluctuations to be relevant in many biomolecular processes. In this paper I discuss a few concepts and…

Statistical Mechanics · Physics 2009-11-11 F. Ritort

Diverse physical systems are characterized by their response to small perturbations. Near thermodynamic equilibrium, the fluctuation-dissipation theorem provides a powerful theoretical and experimental tool to determine the nature of…

Statistical Mechanics · Physics 2020-03-25 Jeremy A. Owen , Todd R. Gingrich , Jordan M. Horowitz

We consider an out-of-equilibrium lattice model consisting of 2D discrete rotators, in contact with heat reservoirs at different temperatures. The equilibrium counterpart of such model, the clock-model, exhibits three phases; a…

Statistical Mechanics · Physics 2019-08-20 Marc Suñé , Alberto Imparato

Fluctuation theorems, which have been developed over the past 15 years, have resulted in fundamental breakthroughs in our understanding of how irreversibility emerges from reversible dynamics, and have provided new statistical mechanical…

Statistical Mechanics · Physics 2015-05-13 E. M. Sevick , R. Prabhakar , Stephen R. Williams , Debra J. Searles

Open many-body quantum systems can exhibit intriguing nonequilibrium phases of matter, such as time crystals. In these phases, the state of the system spontaneously breaks the time-translation symmetry of the dynamical generator, which…

Living systems operate far from thermodynamic equilibrium. Enzymatic activity can induce broken detailed balance at the molecular scale. This molecular scale breaking of detailed balance is crucial to achieve biological functions such as…

Biological Physics · Physics 2018-05-02 F. Gnesotto , F. Mura , J. Gladrow , C. P. Broedersz

Bioreactors are widely used in many industries to generate a range of products using various host cells e.g., yeast, insect, and mammalian cells. Depending on the process, product, and host cell, some bioreactors exhibit sustained periodic…

Quantitative Methods · Quantitative Biology 2023-06-29 Pavan Inguva , Krystian Ganko , Alexis B. Dubs , Richard D. Braatz

A system is glassy when the observation time is much smaller than the equilibration time. A unifying thermodynamic picture of the glassy state is presented. Slow configurational modes are in quasi-equilibrium at an effective temperature. It…

Statistical Mechanics · Physics 2009-10-31 Th. M. Nieuwenhuizen

The time-energy uncertainty relation is often invoked as a heuristic explanation for virtual particles in interacting quantum field theories. However, this interpretation breaks down upon closer scrutiny for several reasons. Although…

Quantum Physics · Physics 2026-03-31 Achintya Sajeendran , Timothy C. Ralph

The fluctuation theorem is the fundamental equality in nonequilibrium thermodynamics that is used to derive many important thermodynamic relations, such as the second law of thermodynamics and the Jarzynski equality. Recently, the…

Statistical Mechanics · Physics 2019-09-16 Yoshihiko Hasegawa , Tan Van Vu

Biological molecular machines are proteins that operate under isothermal conditions hence are referred to as free energy transducers. They can be formally considered as enzymes that simultaneously catalyze two chemical reactions: the free…

Biological Physics · Physics 2014-02-05 Michal Kurzynski , Mieczyslaw Torchala , Przemyslaw Chelminiak