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Mammalian spatial navigation relies on specialized neurons, such as place and grid cells, which encode position based on self-motion and environmental cues. While extensive research has explored the computational role of grid cells, the…

Neurons and Cognition · Quantitative Biology 2026-03-02 Jared Deighton , Wyatt Mackey , Ioannis Schizas , David L. Boothe , Vasileios Maroulas

Estimating information-theoretic quantities such as entropy and mutual information is central to many problems in statistics and machine learning, but challenging in high dimensions. This paper presents estimators of entropy via inference…

Machine Learning · Statistics 2022-12-13 Feras A. Saad , Marco Cusumano-Towner , Vikash K. Mansinghka

As event-based sensing gains in popularity, theoretical understanding is needed to harness this technology's potential. Instead of recording video by capturing frames, event-based cameras have sensors that emit events when their inputs…

Image and Video Processing · Electrical Eng. & Systems 2022-06-10 Karen Adam , Adam Scholefield , Martin Vetterli

In many chemical and biological applications, systems of differential equations containing unknown parameters are used to explain empirical observations and experimental data. The DEs are typically nonlinear and difficult to analyze,…

Quantitative Methods · Quantitative Biology 2015-08-24 D. Goulet

We characterize different cell states, related to cancer and ageing phenotypes, by a measure of entropy of network ensembles, integrating gene expression values and protein interaction networks. The entropy measure estimates the parameter…

Molecular Networks · Quantitative Biology 2013-05-24 G. Menichetti , G. Bianconi , E. Giampieri , G. Castellani , D. Remondini

Biological visual systems learn from limited experience, unlike deep learning models that rely on millions of training images. What learning principles make this possible? We tested whether efficient coding, the idea that neural…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Ananya Passi , Brian S. Robinson , Michael F. Bonner

Cells sense external concentrations and, via biochemical signaling, respond by regulating the expression of target proteins. Both in signaling networks and gene regulation there are two main mechanisms by which the concentration can be…

Subcellular Processes · Quantitative Biology 2017-04-12 Gabriele Micali , Gerardo Aquino , David M. Richards , Robert G. Endres

The investigation of input-output systems often requires a sophisticated choice of test inputs to make best use of limited experimental time. Here we present an iterative algorithm that continuously adjusts an ensemble of test inputs…

Biological Physics · Physics 2009-11-07 Christian K. Machens

The emergent behavior of a distributed system is conditioned by the information available to the local decision-makers. Therefore, one may expect that providing decision-makers with more information will improve system performance; in this…

Computer Science and Game Theory · Computer Science 2023-06-23 Bryce L. Ferguson , Dario Paccagnan , Jason R. Marden

Organisms and ecological groups accumulate evidence to make decisions. Classic experiments and theoretical studies have explored this process when the correct choice is fixed during each trial. However, we live in a constantly changing…

Neurons and Cognition · Quantitative Biology 2015-10-01 Alan Veliz-Cuba , Zachary P. Kilpatrick , Kresimir Josic

Human dynamical social networks encode information and are highly adaptive. To characterize the information encoded in the fast dynamics of social interactions, here we introduce the entropy of dynamical social networks. By analysing a…

Physics and Society · Physics 2012-01-17 Kun Zhao , Márton Karsai , Ginestra Bianconi

Delays in biological systems may be used to model events for which the underlying dynamics cannot be precisely observed. Mathematical modeling of biological systems with delays is usually based on Delay Differential Equations (DDEs), a kind…

Quantitative Methods · Quantitative Biology 2009-10-08 Roberto Barbuti , Giulio Caravagna , Paolo Milazzo , Andrea Maggiolo-Schettini

An event-based state estimation approach for reducing communication in a networked control system is proposed. Multiple distributed sensor-actuator-agents observe a dynamic process and sporadically exchange their measurements and inputs…

Systems and Control · Computer Science 2017-01-30 Sebastian Trimpe

Cell decision-making refers to the process by which cells gather information from their local microenvironment and regulate their internal states to create appropriate responses. Microenvironmental cell sensing plays a key role in this…

Biological Physics · Physics 2023-04-19 Arnab Barua , Haralampos Hatzikirou

In event-based sensing, many sensors independently and asynchronously emit events when there is a change in their input. Event-based sensing can present significant improvements in power efficiency when compared to traditional sampling,…

Image and Video Processing · Electrical Eng. & Systems 2022-01-19 Karen Adam , Adam Scholefield , Martin Vetterli

The growth rate of organisms depends both on external conditions and on internal states, such as the expression levels of various genes. We show that to achieve a criterion mean growth rate over an ensemble of conditions, the internal…

Populations and Evolution · Quantitative Biology 2007-12-31 Samuel F. Taylor , Naftali Tishby , William Bialek

Estimating mutual information accurately is pivotal across diverse applications, from machine learning to communications and biology, enabling us to gain insights into the inner mechanisms of complex systems. Yet, dealing with…

Machine Learning · Computer Science 2024-11-12 Nunzio A. Letizia , Nicola Novello , Andrea M. Tonello

Understanding how the dynamics of neural networks is shaped by the computations they perform is a fundamental question in neuroscience. Recently, the framework of efficient coding proposed a theory of how spiking neural networks can compute…

Neurons and Cognition · Quantitative Biology 2022-10-25 Veronika Koren , Stefano Panzeri

Decision making in modern stochastic systems, including e-commerce platforms, financial markets and healthcare systems, has evolved into a multifaceted process that combines information acquisition and adaptive information sources. This…

Optimization and Control · Mathematics 2026-01-07 Renyuan Xu , Thaleia Zariphopoulou , Luhao Zhang

Measuring Mutual Information (MI) between high-dimensional, continuous, random variables from observed samples has wide theoretical and practical applications. Recent work, MINE (Belghazi et al. 2018), focused on estimating tight…

Machine Learning · Computer Science 2019-05-28 Xiao Lin , Indranil Sur , Samuel A. Nastase , Ajay Divakaran , Uri Hasson , Mohamed R. Amer