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The living cell uses a variety of molecular receptors to read and process chemical signals that vary in space and time. We model the dynamics of such molecular level measurements as Markov processes in steady state, with a coupling between…

Statistical Mechanics · Physics 2017-06-21 Suman G. Das , Garud Iyengar , Madan Rao

Learning the differential statistical dependency network between two contexts is essential for many real-life applications, mostly in the high dimensional low sample regime. In this paper, we propose a novel differential network estimator…

Machine Learning · Computer Science 2022-04-25 Arshdeep Sekhon , Zhe Wang , Yanjun Qi

Time pressure and question difficulty can trigger stress and cognitive overload in web-based surveys, compromising data quality and user experience. Most stress detection methods are based on low-resolution self-reports, which are poorly…

Human-Computer Interaction · Computer Science 2026-01-27 Ailin Liu , Francesco Chiossi , Felix Henninger , Lisa Bondo Andersen , Tobias Wistuba , Sonja Greven , Frauke Kreuter , Fiona Draxler

The problem of communicating sensor measurements over shared networks is prevalent in many modern large-scale distributed systems such as cyber-physical systems, wireless sensor networks, and the internet of things. Due to bandwidth…

Systems and Control · Electrical Eng. & Systems 2021-12-14 Marcos M. Vasconcelos

We study a high-dimensional regression setting under the assumption of known covariate distribution. We aim at estimating the amount of explained variation in the response by the best linear function of the covariates (the signal level). In…

Statistics Theory · Mathematics 2022-05-12 Ilan Livne , David Azriel , Yair Goldberg

The dynamics of stochastic reaction networks within cells are inevitably modulated by factors considered extrinsic to the network such as for instance the fluctuations in ribsome copy numbers for a gene regulatory network. While several…

Quantitative Methods · Quantitative Biology 2015-06-19 Christoph Zechner , Heinz Koeppl

Biochemistry, ecology, and neuroscience are examples of prominent fields aiming at describing interacting systems that exhibit non-trivial couplings to complex, ever-changing environments. We have recently shown that linear interactions and…

Statistical Mechanics · Physics 2022-08-10 Giorgio Nicoletti , Daniel Maria Busiello

Many properties of perceptual decision making are well-modeled by deep neural networks. However, such architectures typically treat decisions as instantaneous readouts, overlooking the temporal dynamics of the decision process. We present…

Neurons and Cognition · Quantitative Biology 2025-11-25 Hayden R. Johnson , Anastasia N. Krouglova , Hadi Vafaii , Jacob L. Yates , Pedro J. Gonçalves

We address the practical problems of estimating the information relations that characterize large networks. Building on methods developed for analysis of the neural code, we show that reliable estimates of mutual information can be obtained…

Information Theory · Computer Science 2007-07-13 Noam Slonim , Gurinder S. Atwal , Gasper Tkacik , William Bialek

Sensors measuring real-life physical processes are ubiquitous in today's interconnected world. These sensors inherently bear noise that often adversely affects performance and reliability of the systems they support. Classic filtering-based…

In this article, we establish a comprehensive theoretical framework for remote estimation in a networked system composed of a source that is observed by a sensor, a remote monitor that needs to estimate the state of the source in real time,…

Information Theory · Computer Science 2026-02-24 Touraj Soleymani , Mohamad Assaad , John S. Baras

Biological and artificial systems encode information through several complex nonlinear operations, making their exact study a formidable challenge. These internal mechanisms often take place across multiple timescales and process external…

Statistical Mechanics · Physics 2024-11-19 Giorgio Nicoletti , Daniel M. Busiello

When cells measure concentrations of chemical signals, they may average multiple measurements over time in order to reduce noise in their measurements. However, when cells are in a environment that changes over time, past measurements may…

Cell Behavior · Quantitative Biology 2025-03-05 Aparajita Kashyap , Wei Wang , Brian A. Camley

Biological organisms are open, adaptve systems that can respond to changes in environment in specific ways. Adaptation and response can be posed as an optimization problem, with a tradeoff between the benefit obtained from a response and…

Statistical Mechanics · Physics 2018-10-17 Suman G. Das , Madan Rao , Garud Iyengar

We study the multi-terminal remote estimation problem under a rate constraint, in which the goal of the encoder is to help each decoder estimate a function over a certain distribution -- while the distribution is known only to the encoder,…

Information Theory · Computer Science 2025-05-13 Maximilian Egger , Rawad Bitar , Antonia Wachter-Zeh , Nir Weinberger , Deniz Gündüz

Many systems in biology, physics and engineering can be described by systems of ordinary differential equation containing many parameters. When studying the dynamic behavior of these large, nonlinear systems, it is useful to identify and…

Molecular Networks · Quantitative Biology 2016-04-13 Heather A. Harrington , Dhagash Mehta , Helen M. Byrne , Jonathan D. Hauenstein

Living cells encode and transmit information in the temporal dynamics of biochemical components. Gaining a detailed understanding of the input-output relationship in biological systems therefore requires quantitative measures that capture…

Molecular Networks · Quantitative Biology 2019-04-04 Lorenzo Duso , Christoph Zechner

In this paper, we consider high-dimensional stationary processes where a new observation is generated from a compressed version of past observations. The specific evolution is modeled by an encoder-decoder structure. We estimate the…

Statistics Theory · Mathematics 2020-09-21 Nathawut Phandoidaen , Stefan Richter

As a living information and communications system, the genome encodes patterns in single nucleotide polymorphisms (SNPs) reflecting human adaption that optimizes population survival in differing environments. This paper mathematically…

Populations and Evolution · Quantitative Biology 2018-03-22 James Lindesay , Tshela E. Mason , William Hercules , Georgia M. Dunston

Living cells are continually exposed to environmental signals that vary in time. These signals are detected and processed by biochemical networks, which are often highly stochastic. To understand how cells cope with a fluctuating…

Molecular Networks · Quantitative Biology 2012-06-01 Wiet de Ronde , Filipe Tostevin , Pieter Rein ten Wolde
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