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Randomized control trials (RCTs) have been the gold standard to evaluate the effectiveness of a program, policy, or treatment on an outcome of interest. However, many RCTs assume that study participants are willing to share their…

Applications · Statistics 2021-12-07 Manjusha Kancharla , Hyunseung Kang

A common challenge for decision makers is selecting actions whose rewards are unknown and evolve over time based on prior policies. For instance, repeated use may reduce an action's effectiveness (habituation), while inactivity may restore…

Machine Learning · Computer Science 2025-11-06 Fengxu Li , Stephanie M. Carpenter , Matthew P. Buman , Yonatan Mintz

Contextual bandits often provide simple and effective personalization in decision making problems, making them popular tools to deliver personalized interventions in mobile health as well as other health applications. However, when bandits…

Machine Learning · Computer Science 2021-07-28 Jiayu Yao , Emma Brunskill , Weiwei Pan , Susan Murphy , Finale Doshi-Velez

An individualized treatment rule (ITR) is a decision rule that aims to improve individual patients health outcomes by recommending optimal treatments according to patients specific information. In observational studies, collected data may…

Methodology · Statistics 2023-10-03 Zeyu Bian , Erica EM Moodie , Susan M Shortreed , Sylvie D Lambert , Sahir Bhatnagar

Digital technologies (e.g., mobile phones) can be used to obtain objective, frequent, and real-world digital phenotypes from individuals. However, modeling these data poses substantial challenges since observational data are subject to…

Applications · Statistics 2026-05-12 Tianchen Xu , Yuan Chen , Donglin Zeng , Yuanjia Wang

The micro-randomized trial (MRT) is a sequential randomized experimental design to empirically evaluate the effectiveness of mobile health (mHealth) intervention components that may be delivered at hundreds or thousands of decision points.…

Methodology · Statistics 2021-12-14 Jieru Shi , Zhenke Wu , Walter Dempsey

Modern randomization methods in clinical trials are invariably adaptive, meaning that the assignment of the next subject to a treatment group uses the accumulated information in the trial. Some of the recent adaptive randomization methods…

Methodology · Statistics 2024-02-12 Alan R. Vazquez , Weng Kee Wong

Estimating individualized treatment rules (ITRs) is fundamental to precision medicine, where the goal is to tailor treatment decisions to individual patient characteristics. While numerous methods have been developed for ITR estimation,…

Methodology · Statistics 2026-05-15 Eun Jeong Oh , Min Qian

Existing strategies for determining the optimal treatment or monitoring strategy typically assume unlimited access to resources. However, when a health system has resource constraints, such as limited funds, access to medication, or…

Applications · Statistics 2019-03-18 Ellen C Caniglia , Eleanor J Murray , Miguel A Hernan , Zach Shahn

We propose a prognostic stratum matching framework that addresses the deficiencies of Randomized trial data subgroup analysis and transforms ObservAtional Data to be used as if they were randomized, thus paving the road for precision…

Applications · Statistics 2023-11-06 Dimitris Bertsimas , Angelos G. Koulouras , Georgios Antonios Margonis

Adherence to prescribed treatments is crucial for individuals with chronic conditions to avoid costly or adverse health outcomes. For certain patient groups, intensive lifestyle interventions are vital for enhancing medication adherence.…

Machine Learning · Computer Science 2025-03-21 Abdullah Mamun , Diane J. Cook , Hassan Ghasemzadeh

Epidemic outbreaks are an important healthcare challenge, especially in developing countries where they represent one of the major causes of mortality. Approaches that can rapidly target subpopulations for surveillance and control are…

Social and Information Networks · Computer Science 2018-07-04 Stefania Rubrichi , Zbigniew Smoreda , Mirco Musolesi

Mobile health has emerged as a major success for tracking individual health status, due to the popularity and power of smartphones and wearable devices. This has also brought great challenges in handling heterogeneous, multi-resolution data…

Methodology · Statistics 2024-05-31 Jiuchen Zhang , Fei Xue , Qi Xu , Jung-Ah Lee , Annie Qu

Main objective of this study is to introduce an expert system-based mHealth application that takes Artificial Intelligence support by considering previously introduced solutions from the literature and employing possible requirements for a…

Human-Computer Interaction · Computer Science 2021-08-23 Ismail Ali Afrah , Utku Kose

With new advancements in technology, it is now possible to collect data for a variety of different metrics describing tumor growth, including tumor volume, composition, and vascularity, among others. For any proposed model of tumor growth…

Quantitative Methods · Quantitative Biology 2020-09-08 Heyrim Cho , Allison L. Lewis , Kathleen M. Storey

Randomized experiments ensure robust causal inference that are critical to effective learning analytics research and practice. However, traditional randomized experiments, like A/B tests, are limiting in large scale digital learning…

Applications · Statistics 2019-02-04 Timothy NeCamp , Josh Gardner , Christopher Brooks

Data volume grows explosively with the proliferation of powerful smartphones and innovative mobile applications. The ability to accurately and extensively monitor and analyze these data is necessary. Much concern in mobile data analysis is…

Computers and Society · Computer Science 2020-09-01 Mohammadhossein Ghahramani , MengChu Zhou , Gang Wang

Recently a new experimental approach, the hybrid experimental design (HED), was introduced to enable investigators to answer scientific questions about building behavioral interventions in which human-delivered and digital components are…

Methodology · Statistics 2026-02-26 Mengbing Li , Inbal Nahum-Shani , Walter Dempsey

Mobile health (mHealth) leverages digital technologies, such as mobile phones, to capture objective, frequent, and real-world digital phenotypes from individuals, enabling the delivery of tailored interventions to accommodate substantial…

Methodology · Statistics 2026-03-24 Xingche Guo , Zexi Cai , Yuanjia Wang , Donglin Zeng

The optimal prophylaxis, and treatment if the prophylaxis fails, for a disease may be best evaluated using a sequential multiple assignment randomised trial (SMART). A SMART is a multi-stage study that randomises a participant to an initial…

Methodology · Statistics 2022-03-25 Robert K. Mahar , Katherine J. Lee , Bibhas Chakraborty , Agus Salim , Julie A. Simpson
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