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Multiscale modelling presents a multifaceted perspective into understanding the mechanisms of the brain and how neurodegenerative disorders like Parkinson's disease (PD) manifest and evolve over time. In this study, we propose a novel…

Neurons and Cognition · Quantitative Biology 2025-09-18 Aaron Herrera , Hina Shaheen

Recent research has provided a wealth of evidence highlighting the pivotal role of high-order interdependencies in supporting the information-processing capabilities of distributed complex systems. These findings may suggest that high-order…

Adaptation and Self-Organizing Systems · Physics 2023-05-24 Patricio Orio , Pedro A. M. Mediano , Fernando E. Rosas

This paper has two messages. First, we demonstrate that neural networks that process noisy data can learn to exploit, when available, access to auxiliary noise that is correlated with the noise on the data. In effect, the network learns to…

Quantum Physics · Physics 2020-09-17 Aida Ahmadzadegan , Petar Simidzija , Ming Li , Achim Kempf

Sequential neuronal activity underlies a wide range of processes in the brain. Neuroscientific evidence for neuronal sequences has been reported in domains as diverse as perception, motor control, speech, spatial navigation and memory.…

Adaptation and Self-Organizing Systems · Physics 2020-04-03 Sascha Frölich , Dimitrije Marković , Stefan J. Kiebel

We present a study investigating the role of mitochondrial variability in generating noise in eukaryotic cells. Noise in cellular physiology plays an important role in many fundamental cellular processes, including transcription,…

Cell Behavior · Quantitative Biology 2015-05-28 Iain G. Johnston , Bernadett Gaal , Ricardo Pires das Neves , Tariq Enver , Francisco J. Iborra , Nick S. Jones

In the cerebral cortex, neurons are subject to a continuous bombardment of synaptic inputs originating from the network's background activity. This leads to ongoing, mostly subthreshold membrane dynamics that depends on the statistics of…

Biological Physics · Physics 2009-11-07 Ulrich Hillenbrand

Parkinson's disease (PD) belongs to the class of neurodegenerative disorders that affect the central nervous system. It is usually defined as the gradual loss of dopaminergic neurons in the substantia nigra pars compacta, which causes both…

Neurons and Cognition · Quantitative Biology 2024-11-01 Hina Shaheen , Roderick Melnik

In recent years, the hardware implementation of neural networks, leveraging physical coupling and analog neurons has substantially increased in relevance. Such nonlinear and complex physical networks provide significant advantages in speed…

Machine Learning · Computer Science 2024-12-05 Nadezhda Semenova , Daniel Brunner

We investigate the efficient transmission and processing of weak, subthreshold signals in a realistic neural medium in the presence of different levels of the underlying noise. Assuming Hebbian weights for maximal synaptic conductances --…

Biological Physics · Physics 2015-08-19 Joaquin J. Torres , Irene Elices , J. Marro

Current computational-emotion research has focused on applying acoustic properties to analyze how emotions are perceived mathematically or used in natural language processing machine learning models. While recent interest has focused on…

Sound · Computer Science 2021-07-06 Daniel Szelogowski

Chaos control techniques have been applied to a wide variety of experimental systems, including magneto-elastic ribbons, lasers, chemical reactions, arrhythmic cardiac tissue, and spontaneously bursting neuronal networks. An underlying…

chao-dyn · Physics 2008-02-03 David J. Christini , James J. Collins

Stochastic neurons can be useful for a number of reasons in deep learning models, but in many cases they pose a challenging problem: how to estimate the gradient of a loss function with respect to the input of such stochastic neurons, i.e.,…

Machine Learning · Computer Science 2013-05-15 Yoshua Bengio

Function and dysfunctions of neural systems are tied to the temporal evolution of neural states. The current limitations in showing their causal role stem largely from the absence of tools capable of probing the brain's internal state in…

Neurons and Cognition · Quantitative Biology 2024-09-24 Ayesha Vermani , Matthew Dowling , Hyungju Jeon , Ian Jordan , Josue Nassar , Yves Bernaerts , Yuan Zhao , Steven Van Vaerenbergh , Il Memming Park

Spiking neural networks (SNNs) have emerged as energy-efficient neural networks with temporal information. SNNs have shown a superior efficiency on neuromorphic devices, but the devices are susceptible to noise, which hinders them from…

Neural and Evolutionary Computing · Computer Science 2021-04-23 Seongsik Park , Dongjin Lee , Sungroh Yoon

Similar to intelligent multicellular neural networks controlling human brains, even single cells surprisingly are able to make intelligent decisions to classify several external stimuli or to associate them. This happens because of the fact…

Molecular Networks · Quantitative Biology 2018-11-21 Russell Bates , Oleg Blyuss , Ahmed Alsaedi , Alexey Zaikin

Regulation of intrinsic noise in gene expression is essential for many cellular functions. Correspondingly, there is considerable interest in understanding how different molecular mechanisms of gene expression impact variations in protein…

Molecular Networks · Quantitative Biology 2011-03-02 Tao Jia , Rahul V. Kulkarni

Computational Social Science (CSS) is an emerging field driven by the unprecedented availability of human-generated content for researchers. This field, however, presents a unique set of challenges due to the nature of the theories and…

Computation and Language · Computer Science 2025-03-11 Nadav Borenstein

We have analyzed the effects of the addition of external noise to non-dynamical systems displaying intrinsic noise, and established general conditions under which stochastic resonance appears. The criterion we have found may be applied to a…

Condensed Matter · Physics 2016-08-15 J. M. G. Vilar , G. Gomila , J. M. Rubí

Recurrent Neural networks (RNN) have shown promising potential for learning dynamics of sequential data. However, artificial neural networks are known to exhibit poor robustness in presence of input noise, where the sequential architecture…

Machine Learning · Computer Science 2021-05-05 Arash Amini , Guangyi Liu , Nader Motee

We investigate the role of noise in the phenomenon of stochastic synchronization of switching events in a rocked, overdamped bistable potential driven by white Gaussian noise, the archetype description of Stochastic Resonance. We present a…

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