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Deep learning-based automated contouring and treatment planning has been proven to improve the efficiency and accuracy of radiotherapy. However, conventional radiotherapy treatment planning process has the automated contouring and treatment…

Medical Physics · Physics 2024-12-02 Sangwook Kim , Aly Khalifa , Thomas G. Purdie , Chris McIntosh

An individualized treatment rule (ITR) tailors treatments to a patient's specific characteristics. However, randomized controlled trials (RCTs) are often underpowered to detect the treatment effect heterogeneity needed for reliable ITR…

Methodology · Statistics 2026-04-14 Yuan Bian , Donglin Zeng , Hyun-Joon Yang , Leanne M. Williams , Yuanjia Wang

We present a novel methodology to jointly perform multi-task learning and infer intrinsic relationship among tasks by an interpretable and sparse graph. Unlike existing multi-task learning methodologies, the graph structure is not assumed…

Machine Learning · Computer Science 2020-09-15 Shujian Yu , Francesco Alesiani , Ammar Shaker , Wenzhe Yin

Detailed mobile sensing data from phones, watches, and fitness trackers offer an unparalleled opportunity to quantify and act upon previously unmeasurable behavioral changes in order to improve individual health and accelerate responses to…

Machine Learning · Computer Science 2022-06-06 Mike A. Merrill , Tim Althoff

Transformer-based models, even though achieving super-human performance on several downstream tasks, are often regarded as a black box and used as a whole. It is still unclear what mechanisms they have learned, especially their core module:…

Computation and Language · Computer Science 2023-10-17 Chong Li , Shaonan Wang , Yunhao Zhang , Jiajun Zhang , Chengqing Zong

Transfer learning has aroused great interest in the statistical community. In this article, we focus on knowledge transfer for unsupervised learning tasks in contrast to the supervised learning tasks in the literature. Given the…

Machine Learning · Statistics 2024-03-13 Zeyu Li , Kangxiang Qin , Yong He , Wang Zhou , Xinsheng Zhang

Large-scale pre-trained models have achieved remarkable success in various computer vision tasks. A standard approach to leverage these models is to fine-tune all model parameters for downstream tasks, which poses challenges in terms of…

Computer Vision and Pattern Recognition · Computer Science 2023-12-18 Yi Xin , Junlong Du , Qiang Wang , Zhiwen Lin , Ke Yan

Fine-tuning large pre-trained language models on downstream tasks has become the de-facto learning paradigm in NLP. However, conventional approaches fine-tune all the parameters of the pre-trained model, which becomes prohibitive as the…

Computation and Language · Computer Science 2022-02-03 Junxian He , Chunting Zhou , Xuezhe Ma , Taylor Berg-Kirkpatrick , Graham Neubig

This paper proposes a novel learning method for multi-task applications. Multi-task neural networks can learn to transfer knowledge across different tasks by using parameter sharing. However, sharing parameters between unrelated tasks can…

Machine Learning · Computer Science 2020-07-21 Krzysztof Maziarz , Efi Kokiopoulou , Andrea Gesmundo , Luciano Sbaiz , Gabor Bartok , Jesse Berent

Growing evidence from recent studies implies that microRNA or miRNA could serve as biomarkers in various complex human diseases. Since wet-lab experiments are expensive and time-consuming, computational techniques for miRNA-disease…

Quantitative Methods · Quantitative Biology 2021-11-30 Thi Ngan Dong , Megha Khosla

Drug combination therapy is a well-established strategy for disease treatment with better effectiveness and less safety degradation. However, identifying novel drug combinations through wet-lab experiments is resource intensive due to the…

Machine Learning · Computer Science 2023-01-18 Zhihang Hu , Qinze Yu , Yucheng Guo , Taifeng Wang , Irwin King , Xin Gao , Le Song , Yu Li

The pre-training and fine-tuning paradigm has become prominent in transfer learning. For example, if the model is pre-trained on ImageNet and then fine-tuned to PASCAL, it can significantly outperform that trained on PASCAL from scratch.…

Image and Video Processing · Electrical Eng. & Systems 2025-01-22 Wenxuan Li , Alan Yuille , Zongwei Zhou

Purpose: Neural networks have received recent interest for reconstruction of undersampled MR acquisitions. Ideally network performance should be optimized by drawing the training and testing data from the same domain. In practice, however,…

Computer Vision and Pattern Recognition · Computer Science 2019-05-07 Salman Ul Hassan Dar , Muzaffer Özbey , Ahmet Burak Çatlı , Tolga Çukur

Accurate prediction of postoperative complications can inform shared decisions regarding prognosis, preoperative risk-reduction, and postoperative resource use. We hypothesized that multi-task deep learning models would outperform random…

Fueled by breakthrough technology developments, the biological, biomedical, and behavioral sciences are now collecting more data than ever before. There is a critical need for time- and cost-efficient strategies to analyze and interpret…

Predicting materials properties from composition or structure is of great interest to the materials science community. Deep learning has recently garnered considerable interest in materials predictive tasks with low model errors when…

Materials Science · Physics 2021-11-01 Chi Chen , Shyue Ping Ong

In the paradigm of multi-task learning, mul- tiple related prediction tasks are learned jointly, sharing information across the tasks. We propose a framework for multi-task learn- ing that enables one to selectively share the information…

Machine Learning · Computer Science 2012-07-03 Abhishek Kumar , Hal Daume

Explainable ML for molecular toxicity prediction is a promising approach for efficient drug development and chemical safety. A predictive ML model of toxicity can reduce experimental cost and time while mitigating ethical concerns by…

Quantitative Methods · Quantitative Biology 2022-04-15 Bhanushee Sharma , Vijil Chenthamarakshan , Amit Dhurandhar , Shiranee Pereira , James A. Hendler , Jonathan S. Dordick , Payel Das

Bioactivity data plays a key role in drug discovery and repurposing. The resource-demanding nature of \textit{in vitro} and \textit{in vivo} experiments, as well as the recent advances in data-driven computational biochemistry research,…

Deep learning has become a promising approach for automated medical diagnoses. When medical data samples are limited, collaboration among multiple institutions is necessary to achieve high algorithm performance. However, sharing patient…

Computer Vision and Pattern Recognition · Computer Science 2017-09-19 Ken Chang , Niranjan Balachandar , Carson K Lam , Darvin Yi , James M Brown , Andrew Beers , Bruce R Rosen , Daniel L Rubin , Jayashree Kalpathy-Cramer
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