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Related papers: Enhanced sampling of transition states

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In this work, we present Enhanced Representation-Based Sampling (ERBS), a novel enhanced sampling method designed to generate structurally diverse training datasets for machine-learned interatomic potentials. ERBS automatically identifies…

Chemical Physics · Physics 2026-01-23 Moritz René Schäfer , Johannes Kästner

Sampling from unnormalized densities using diffusion models has emerged as a powerful paradigm. However, while recent approaches that use least-squares `matching' objectives have improved scalability, they often necessitate significant…

Machine Learning · Computer Science 2026-03-03 Denis Blessing , Lorenz Richter , Julius Berner , Egor Malitskiy , Gerhard Neumann

Transition states, the first-order saddle points on the potential energy surfaces, govern the kinetics and mechanisms of chemical reactions and conformational changes. Locating them is challenging because transition pathways are…

Chemical Physics · Physics 2026-04-30 Hyukjun Lim , Soojung Yang , Lucas Pinède , Miguel Steiner , Yuanqi Du , Rafael Gómez-Bombarelli

Wang-Landau sampling (WLS) of large systems requires dividing the energy range into "windows" and joining the results of simulations in each window. The resulting density of states (and associated thermodynamic functions) are shown to…

Statistical Mechanics · Physics 2009-11-13 A. G. Cunha-Netto , A. A. Caparica , Shan-Ho Tsai , Ronald Dickman , D. P. Landau

We present an algorithm to sample stochastic differential equations conditioned on rather general constraints, including integral constraints, endpoint constraints, and stochastic integral constraints. The algorithm is a pathspace…

Machine Learning · Statistics 2025-06-23 Tobias Grafke

Rare transitions between long-lived stable states are often analyzed in terms of free energy landscapes computed as functions of a few collective variables. Here, using transitions between geometric phases as example, we demonstrate that…

Computational Physics · Physics 2017-08-11 Clemens Moritz , Andreas Tröster , Christoph Dellago

We describe a variational approach to solving optimal stopping problems for diffusion processes, as an alternative to the traditional approach based on the solution of the free-boundary problem. We study smooth pasting conditions from a…

Probability · Mathematics 2015-08-06 V. I. Arkin , A. D. Slastnikov

As Diffusion Models have shown promising performance, a lot of efforts have been made to improve the controllability of Diffusion Models. However, how to train Diffusion Models to have the disentangled latent spaces and how to naturally…

Computer Vision and Pattern Recognition · Computer Science 2025-07-02 Wonwoong Cho , Hareesh Ravi , Midhun Harikumar , Vinh Khuc , Krishna Kumar Singh , Jingwan Lu , David I. Inouye , Ajinkya Kale

In this thesis we examine methodologies for determining free energy differences (FEDs) of phases via Monte Carlo simulation. We identify and address three generic issues that arise in FED calculations; the choice of representation, the…

Statistical Mechanics · Physics 2009-09-29 Arjun R. Acharya

Spectral-spatial processing has been increasingly explored in remote sensing hyperspectral image classification. While extensive studies have focused on developing methods to improve the classification accuracy, experimental setting and…

Computer Vision and Pattern Recognition · Computer Science 2017-03-08 Jie Liang , Jun Zhou , Yuntao Qian , Lian Wen , Xiao Bai , Yongsheng Gao

Many materials processes and properties depend on the anisotropy of the energy of grain boundaries, i.e.~on the fact that this energy is a function of the five geometric degrees of freedom (DOF) of the interface. To access this parameter…

Materials Science · Physics 2023-07-26 Timo Schmalofski , Martin Kroll , Holger Dette , Rebecca Janisch

This paper explores the challenges and benefits of a trainable destruction process in diffusion samplers -- diffusion-based generative models trained to sample an unnormalised density without access to data samples. Contrary to the majority…

In this work, we propose FastDPM, a unified framework for fast sampling in diffusion probabilistic models. FastDPM generalizes previous methods and gives rise to new algorithms with improved sample quality. We systematically investigate the…

Machine Learning · Computer Science 2021-06-25 Zhifeng Kong , Wei Ping

Physically motivated stochastic dynamics are often used to sample from high-dimensional distributions. However such dynamics often get stuck in specific regions of their state space and mix very slowly to the desired stationary state. This…

Machine Learning · Statistics 2025-05-13 Abhijith Jayakumar , Andrey Y. Lokhov , Sidhant Misra , Marc Vuffray

In this study, we introduce a novel method for generating new synthetic samples that are independent and identically distributed (i.i.d.) from high-dimensional real-valued probability distributions, as defined implicitly by a set of Ground…

Machine Learning · Statistics 2024-07-09 Hamidreza Behjoo , Michael Chertkov

Sampling from a distribution $p(x) \propto e^{-\mathcal{E}(x)}$ known up to a normalising constant is an important and challenging problem in statistics. Recent years have seen the rise of a new family of amortised sampling algorithms,…

Machine Learning · Computer Science 2026-05-29 Arran Carter , Sanghyeok Choi , Kirill Tamogashev , Víctor Elvira , Esmeralda S. Whitammer

In theories with topological sectors, such as lattice QCD and four-dimensional SU(N) gauge theories with periodic boundary conditions, conventional update algorithms suffer from topological freezing due to large action barriers separating…

High Energy Physics - Lattice · Physics 2026-04-07 Timo Eichhorn , Gianluca Fuwa , Christian Hoelbling , Lukas Varnhorst

Biomolecular machines transduce between different forms of energy. These machines make directed progress and increase their speed by consuming free energy, typically in the form of nonequilibrium chemical concentrations. Machine dynamics…

Statistical Mechanics · Physics 2018-10-05 Aidan I Brown , David A Sivak

We study the problem of finding efficient sampling policies in an edge-based feedback system, where sensor samples are offloaded to a back-end server that processes them and generates feedback to a user. Sampling the system at maximum…

Information Theory · Computer Science 2023-02-07 Vishnu Narayanan Moothedath , Jaya Prakash Champati , James Gross

The sampling method has been paid much attention in the field of complex network in general and statistical physics in particular. This paper presents two new sampling methods based on the perspective that a small part of vertices with high…

Physics and Society · Physics 2014-05-23 Luo Peng , Li Yongli , Wu Chong