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In this paper, we study error-correcting codes for the storage of data in synthetic deoxyribonucleic acid (DNA). We investigate a storage model where data is represented by an unordered set of $M$ sequences, each of length $L$. Errors…

Information Theory · Computer Science 2018-05-10 Andreas Lenz , Paul H. Siegel , Antonia Wachter-Zeh , Eitan Yaakobi

DNA sequences are prone to creating secondary structures by folding back on themselves by non-specific hybridization among its nucleotides. The formation of secondary structures makes the sequences chemically inactive towards synthesis and…

Information Theory · Computer Science 2022-11-30 Siddhartha Siddhiprada Bhoi , Paramapalli Udaya , Abhay Kumar Singh

A method for encoding information in DNA sequences is described. The method is based on the precision-resolution framework, and is aimed to work in conjunction with a recently suggested terminator-free template independent DNA synthesis…

Information Theory · Computer Science 2020-05-14 Siddharth Jain , Farzad Farnoud , Moshe Schwartz , Jehoshua Bruck

DNA is a promising storage medium, but its stability and occurrence of Indel errors pose a significant challenge. The relative occurrence of Guanine(G) and Cytosine(C) in DNA is crucial for its longevity, and reverse complementary base…

Information Theory · Computer Science 2024-01-15 NallappaBhavithran G , Selvakumar R

Motivated by the sequence reconstruction problem initiated by Levenshtein, reconstruction codes were introduced by Cai \emph{et al}. to combat errors when a fixed number of noisy channels are available. The central problem on this topic is…

Information Theory · Computer Science 2022-07-05 Rongsheng Wu , Xiande Zhang

We study the amount of reliable information that can be stored in a DNA-based storage system composed of short DNA molecules. In this regime, Shomorony and Heckel (2022) put forward a conjecture on the scaling of the number of information…

Information Theory · Computer Science 2025-11-19 Ran Tamir , Nir Weinberger , Albert Guillén i Fàbregas

Due to its longevity and enormous information density, DNA is an attractive medium for archival storage. In this work, we study the fundamental limits and tradeoffs of DNA-based storage systems under a simple model, motivated by current…

Information Theory · Computer Science 2017-05-16 Reinhard Heckel , Ilan Shomorony , Kannan Ramchandran , David N. C. Tse

In this work, we study two types of constraints on two-dimensional binary arrays. In particular, given $p,\epsilon>0$, we study (i) The $p$-bounded constraint: a binary vector of size $m$ is said to be $p$-bounded if its weight is at most…

Information Theory · Computer Science 2022-08-22 Tuan Thanh Nguyen , Kui Cai , Han Mao Kiah , Kees A. Schouhamer Immink , Yeow Meng Chee

To equip DNA-based data storage with random-access capabilities, Yazdi et al. (2018) prepended DNA strands with specially chosen address sequences called primers and provided certain design criteria for these primers. We provide explicit…

Information Theory · Computer Science 2019-01-07 Yeow Meng Chee , Han Mao Kiah , Hengjia Wei

We consider error-correcting coding for deoxyribonucleic acid (DNA)-based storage using nanopore sequencing. We model the DNA storage channel as a sampling noise channel where the input data is chunked into $M$ short DNA strands, which are…

Information Theory · Computer Science 2024-06-21 Lorenz Welter , Roman Sokolovskii , Thomas Heinis , Antonia Wachter-Zeh , Eirik Rosnes , Alexandre Graell i Amat

In this paper we study error-correcting codes for the storage of data in synthetic deoxyribonucleic acid (DNA). We investigate a storage model where a data set is represented by an unordered set of $M$ sequences, each of length $L$. Errors…

Information Theory · Computer Science 2020-02-13 Andreas Lenz , Paul H. Siegel , Antonia Wachter-Zeh , Eitan Yaakobi

The design of large libraries of oligonucleotides having constant GC-content and satisfying Hamming distance constraints between oligonucleotides and their Watson-Crick complements is important in reducing hybridization errors in DNA…

Information Theory · Computer Science 2008-03-27 Yeow Meng Chee , San Ling

A new family of codes, called clustering-correcting codes, is presented in this paper. This family of codes is motivated by the special structure of data that is stored in DNA-based storage systems. The data stored in these systems has the…

Information Theory · Computer Science 2019-03-12 Tal Shinkar , Eitan Yaakobi , Andreas Lenz , Antonia Wachter-Zeh

Modern biological science produces vast amounts of genomic sequence data. This is fuelling the need for efficient algorithms for sequence compression and analysis. Data compression and the associated techniques coming from information…

Data Structures and Algorithms · Computer Science 2011-09-05 Heba Afify , Muhammad Islam , Manal Abdel Wahed

The process of DNA-based data storage (DNA storage for short) can be mathematically modelled as a communication channel, termed DNA storage channel, whose inputs and outputs are sets of unordered sequences. To design error correcting codes…

Information Theory · Computer Science 2020-06-11 Wentu Song , Kui Cai , Kees A. Schouhamer Immink

We consider a new family of codes, termed asymmetric Lee distance codes, that arise in the design and implementation of DNA-based storage systems and systems with parallel string transmission protocols. The codewords are defined over a…

Information Theory · Computer Science 2016-12-16 Ryan Gabrys , Han Mao Kiah , Olgica Milenkovic

Error-correcting codes over sets, with applications to DNA storage, are studied. The DNA-storage channel receives a set of sequences, and produces a corrupted version of the set, including sequence loss, symbol substitution, symbol…

Information Theory · Computer Science 2021-07-12 Hengjia Wei , Moshe Schwartz

As a possible implementation of data storage using DNA, multiple strands of DNA are stored in a liquid container so that, in the future, they can be read by an array of DNA readers in parallel. These readers will sample the strands with…

Information Theory · Computer Science 2024-09-04 Hsin-Po Wang , Venkatesan Guruswami

Living in the age of the digital media explosion, the amount of data that is being stored increases dramatically. However, even if existing storage systems suggest efficiency in capacity, they are lacking in durability. Hard disks, flash,…

Image and Video Processing · Electrical Eng. & Systems 2019-04-08 Melpomeni Dimopoulou , Marc Antonini , Pascal Barbry , Raja Appuswamy

Convolutional codes are error-correcting linear codes that utilize shift registers to encode. These codes have an arbitrary block size and they can incorporate both past and current information bits. DNA codes represent DNA sequences and…

Information Theory · Computer Science 2021-11-09 Paridhi Latawa , Nuh Aydin