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Recent technological advances in cutting-edge ultrasensitive fluorescence microscopy have allowed single-molecule imaging experiments in living cells across all three domains of life to become commonplace. Single-molecule live-cell data is…

Biomolecules · Quantitative Biology 2015-04-15 Mark Leake

Localization microscopy is an imaging technique in which the positions of individual nanoscale point emitters (e.g. fluorescent molecules) are determined at high precision from their images. This is the key ingredient in…

Image and Video Processing · Electrical Eng. & Systems 2020-10-01 Elias Nehme , Daniel Freedman , Racheli Gordon , Boris Ferdman , Lucien E. Weiss , Onit Alalouf , Reut Orange , Tomer Michaeli , Yoav Shechtman

We propose the use of Flat Metric to assess the performance of reconstruction methods for single-molecule localization microscopy (SMLM) in scenarios where the ground-truth is available. Flat Metric is intimately related to the concept of…

Image and Video Processing · Electrical Eng. & Systems 2021-02-09 Quentin Denoyelle , Thanh-an Pham , Pol del Aguila Pla , Daniel Sage , Michael Unser

In single-molecule super-resolution microscopy, engineered point-spread functions (PSFs) are designed to efficiently encode new molecular properties, such as 3D orientation, into complex spatial features captured by a camera. To fully…

Image and Video Processing · Electrical Eng. & Systems 2019-07-16 Hesam Mazidi , Eshan S. King , Oumeng Zhang , Arye Nehorai , Matthew D. Lew

In this paper we consider maximum-likelihood (ML) MIMO detection under one-bit quantized observations and binary symbol constellations. This problem is motivated by the recent interest in adopting coarse quantization in massive MIMO…

Information Theory · Computer Science 2021-02-24 Mingjie Shao , Wing-Kin Ma

We explore theoretically the electroluminescence of single molecules. We adopt a local-electrode framework that is appropriate for scanning tunneling microscopy (STM) experiments where electroluminescence originates from individual…

Mesoscale and Nanoscale Physics · Physics 2009-11-13 John Buker , George Kirczenow

Weakly supervised localization aims at finding target object regions using only image-level supervision. However, localization maps extracted from classification networks are often not accurate due to the lack of fine pixel-level…

Computer Vision and Pattern Recognition · Computer Science 2020-08-13 Xiaolin Zhang , Yunchao Wei , Yi Yang

The use of photo-activated fluorescent molecules to create long sequences of low emitter-density diffraction-limited images enables high-precision emitter localization, but at the cost of low temporal resolution. We suggest combining…

Image and Video Processing · Electrical Eng. & Systems 2023-07-19 Gili Dardikman-Yoffe , Yonina C. Eldar

A single-pixel digital holography system with phase-encoded illumination using a digital micromirror device (DMD) as a spatial light modulator (SLM) is presented. The enhanced switching rate of DMDs, far exceeding the stringent frame-rate…

Recently, super-resolution ultrasound imaging with ultrasound localization microscopy (ULM) has received much attention. However, ULM relies on low concentrations of microbubbles in the blood vessels, ultimately resulting in long…

In this paper, we consider a simple coding scheme for spatial modulation (SM), where the same set of active transmit antennas is repeatedly used over consecutive multiple transmissions. Based on a Gaussian approximation, an approximate…

Information Theory · Computer Science 2019-01-01 Jinho Choi

Low-light image enhancement (LLIE) aims to improve the illuminance of images due to insufficient light exposure. Recently, various lightweight learning-based LLIE methods have been proposed to handle the challenges of unfavorable prevailing…

Computer Vision and Pattern Recognition · Computer Science 2023-05-24 Yuantong Zhang , Baoxin Teng , Daiqin Yang , Zhenzhong Chen , Haichuan Ma , Gang Li , Wenpeng Ding

Single-image super-resolution (SISR) typically focuses on restoring various degraded low-resolution (LR) images to a single high-resolution (HR) image. However, during SISR tasks, it is often challenging for models to simultaneously…

Image and Video Processing · Electrical Eng. & Systems 2023-11-10 Xin Wang , Jing-Ke Yan , Jing-Ye Cai , Jian-Hua Deng , Qin Qin , Yao Cheng

The facility location problem is widely used for summarizing large datasets and has additional applications in sensor placement, image retrieval, and clustering. One difficulty of this problem is that submodular optimization algorithms…

Machine Learning · Statistics 2017-03-09 Erik M. Lindgren , Shanshan Wu , Alexandros G. Dimakis

In this paper, Sphere Decoding (SD) algorithms for Spatial Modulation (SM) are developed to reduce the computational complexity of Maximum-Likelihood (ML) detectors. Two SDs specifically designed for SM are proposed and analysed in terms of…

Information Theory · Computer Science 2013-05-31 Abdelhamid Younis , Sinan Sinanović , Marco Di Renzo , Raed Mesleh , Harald Haas

Quantifying the number of molecules from fluorescence microscopy measurements is an important topic in cell biology and medical research. In this work, we present a consecutive algorithm for super-resolution (STED) scanning microscopy that…

Applications · Statistics 2023-10-03 Katharina Proksch , Frank Werner , Jan Keller-Findeisen , Haisen Ta , Axel Munk

Multifocal microscopy (MFM) offers high-speed three-dimensional imaging through the simultaneous image capture from multiple focal planes. Conventional MFM systems use a fabricated grating in the emission path for a single emission…

Biological Physics · Physics 2019-07-31 M. Junaid Amin , Sabine Petry , Haw Yang , Joshua W. Shaevitz

This paper focuses on the problem of localising a transmitting mobile station (MS) using multiple cooperative base stations (BSs). There are two technical difficulties: one is the data association between intermediate parameters and…

Signal Processing · Electrical Eng. & Systems 2019-11-21 Hengyan Liu , Wei Dai , Yuan Shen

We introduce a novel method for solving density-based topology optimization problems: Sigmoidal Mirror descent with a Projected Latent variable (SiMPL). The SiMPL method (pronounced as ``the simple method'') optimizes a design using only…

Optimization and Control · Mathematics 2025-02-25 Dohyun Kim , Boyan Stefanov Lazarov , Thomas M. Surowiec , Brendan Keith

Linear inverse problems $A \mu = \delta$ with Poisson noise and non-negative unknown $\mu \geq 0$ are ubiquitous in applications, for instance in Positron Emission Tomography (PET) in medical imaging. The associated maximum likelihood…

Optimization and Control · Mathematics 2020-02-24 Camille Pouchol , Olivier Verdier