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The brain white matter consists of a set of tracts that connect distinct regions of the brain. Segmentation of these tracts is often needed for clinical and research studies. Diffusion-weighted MRI offers unique contrast to delineate these…
White matter parcellation classifies tractography streamlines into clusters or anatomically meaningful tracts to enable quantification and visualization. Most parcellation methods focus on the deep white matter (DWM), while fewer methods…
The individual course of white matter fiber tracts is an important key for analysis of white matter characteristics in healthy and diseased brains. Uniquely, diffusion-weighted MRI tractography in combination with region-based or…
Diffusion MRI (dMRI) provides a distinctive means to probe the microstructural architecture of living tissue, facilitating applications such as brain connectivity analysis, modeling across multiple conditions, and the estimation of…
This paper presents DDTracking, a novel deep generative framework for diffusion MRI tractography that formulates streamline propagation as a conditional denoising diffusion process. In DDTracking, we introduce a dual-pathway encoding…
We propose a new method, Patch-CNN, for diffusion tensor (DT) estimation from only six-direction diffusion weighted images (DWI). Deep learning-based methods have been recently proposed for dMRI parameter estimation, using either voxel-wise…
Tractography fiber clustering using diffusion MRI (dMRI) is a crucial strategy for white matter (WM) parcellation. Current methods primarily use the geometric information of fibers (i.e., the spatial trajectories) to group similar fibers…
Fiber tractography is an important tool of computational neuroscience that enables reconstructing the spatial connectivity and organization of white matter of the brain. Fiber tractography takes advantage of diffusion Magnetic Resonance…
Fibre orientation distribution (FOD) reconstruction using deep learning has the potential to produce accurate FODs from a reduced number of diffusion-weighted images (DWIs), decreasing total imaging time. Diffusion acquisition invariant…
In structural brain networks the connections of interest consist of white-matter fibre bundles between spatially segregated brain regions. The presence, location and orientation of these white matter tracts can be derived using diffusion…
Diffusion MRI tractography enables in vivo reconstruction of white matter (WM) pathways. Two key tasks in tractography analysis include: 1) tractogram registration that aligns streamlines across individuals, and 2) streamline clustering…
Diffusion-weighted imaging (DWI) is a type of Magnetic Resonance Imaging (MRI) technique sensitised to the diffusivity of water molecules, offering the capability to inspect tissue microstructures and is the only in-vivo method to…
Tractograms are virtual representations of the white matter fibers of the brain. They are of primary interest for tasks like presurgical planning, and investigation of neuroplasticity or brain disorders. Each tractogram is composed of…
Diffusion weighted MRI (dMRI) provides a non invasive virtual reconstruction of the brain's white matter structures through tractography. Analyzing dMRI measures along the trajectory of white matter bundles can provide a more specific…
Fiber tracking based on diffusion weighted Magnetic Resonance Imaging (dMRI) allows for noninvasive reconstruction of fiber bundles in the human brain. In this chapter, we discuss sources of error and uncertainty in this technique, and…
White matter fiber clustering is an important strategy for white matter parcellation, which enables quantitative analysis of brain connections in health and disease. In combination with expert neuroanatomical labeling, data-driven white…
Biophysical modelling of the diffusion MRI signal provides estimates of specific microstructural tissue properties. Although nonlinear optimization such as non-linear least squares (NLLS) is the most widespread method for model estimation,…
Diffusion MRI (dMRI) streamline tractography, the gold standard for in vivo estimation of brain white matter (WM) pathways, has long been considered indicative of macroscopic relationships with WM microstructure. However, recent advances in…
Diffusion-weighted magnetic resonance imaging (dMRI) is widely used to assess the brain white matter. One of the most common computations in dMRI involves cross-subject tract-specific analysis, whereby dMRI-derived biomarkers are compared…
Diffusion-weighted magnetic resonance imaging (DWI) and fiber tractography are the only methods to measure the structure of the white matter in the living human brain. The diffusion signal has been modelled as the combined contribution from…