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Refractive index sensing is a highly sensitive and label-free detection method for molecular binding events. Commercial implementations of biosensing concepts based on plasmon resonances typically require significant external…

Instrumentation and Detectors · Physics 2019-02-05 Lion Augel , Yuma Kawaguchi , Stefan Bechler , Roman Körner , Jörg Schulze , Hironaga Uchida , Inga A. Fischer

We have implemented a multi-functional optofluidic sensor that can monitor changes in the refractive index and pressure of biofluid simultaneously and can detect free-solution molecular interaction in-situ. In this paper, we demonstrate two…

Optics · Physics 2014-10-16 Zhida Xu , Logan Liu

Photonic integrated circuit devices can be used as refractometric opto-fluidic sensors to detect the presence of analytes in solution at low concentrations. In this work, we investigate the refractive index sensitivity of silicon nitride…

We report on a novel optofluidic system consisting of a silica-based 1D photonic crystal, integrated planar waveguides and electrically insulated fluidic channels. An array of pillars in a microfluidic channel designed for…

Optics · Physics 2008-09-24 P. S. Nunes , N. A. Mortensen , J. P. Kutter , K. B. Mogensen

We report the implementation of a fully on-chip, lensless microscopy technique termed optofluidic ptychography. This imaging modality complements the miniaturization provided by microfluidics and allows the integration of ptychographic…

Instrumentation and Detectors · Physics 2021-12-21 Pengming Song , Chengfei Guo , Shaowei Jiang , Tianbo Wang , Patrick Hu , Derek Hu , Zibang Zhang , Bin Feng , Guoan Zheng

Portable and cost-effective gas sensors are gaining demand for a number of environmental, biomedical and industrial applications, yet current devices are confined into specialized labs and cannot be extended to general use. Here, we…

Instrumentation and Detectors · Physics 2020-04-10 Giuseppe Antonacci , Jeroen Goyvaerts , Haolan Zhao , Bettina Baumgartner , Bernhard Lendl , Roel Baets

In this work, a refractive index (RI) sensor with an effective integration of colorimetric detection and optical sensing capabilities has been developed. Colorimetric detection relies on the sensitivity of the structural color of photonic…

Optics · Physics 2021-07-09 Cheng Fang , Qingqing Shang , Fen Tang , Songlin Yang , Ran Ye

Lab-on-a-chip (LOC) applications have emerged as invaluable physical and life sciences tools. The advantages stem from advanced system miniaturization, thus, requiring far less sample volume while allowing for complex functionality,…

Label-free detecting multiple analytes in a high-throughput fashion has been one of the long-sought goals in biosensing applications. Yet, for all-optical approaches, interfacing state-of-the-art label-free techniques with microfluidics…

Quantitative Methods · Quantitative Biology 2023-08-14 Alexia Stollmann , Jose Garcia-Guirado , Jae-Sang Hong , Hyungsoon Im , Hakho Lee , Jaime Ortega Arroyo , Romain Quidant

Optofluidic sensors based on highly dispersive two-dimensional photonic crystal waveguides are theoretically studied. Results show that these structures are strongly sensitive to the refractive index of the infiltrated liquid (nl), which is…

Optics · Physics 2011-11-10 Sanshui Xiao , Niels Asger Mortensen

Adaptive optics in combination with multi-photon techniques is a powerful approach to image deep into a specimen. Remarkably, virtually all adaptive optics schemes today rely on wavefront modulators which are reflective, diffractive, or…

The recent development of opto-mechano-fluidic resonators has provided -- by harnessing photon radiation pressure -- a new microfluidics platform for the optical sensing of fluid density and bulk modulus. Here we show that fluid viscosity…

Optics · Physics 2014-07-15 Kewen Han , Kaiyuan Zhu , Gaurav Bahl

Miniaturized, low-cost wavelength detectors are gaining enormous interest as we step into the new age of photonics. Incompatibility with integrated circuits or complex fabrication requirement in most of the conventionally used filters…

High-Q optical resonators allow label-free detection of individual nanoparticles through perturbation of optical signatures but have practical limitations due to reliance on random diffusion to deliver particles to the sensing region. We…

Optics · Physics 2016-10-03 Jeewon Suh , Kewen Han , Christopher W Peterson , Gaurav Bahl

Optofluidics is dedicated to achieving integrated control of particle and fluid motion, particularly on the micrometer scale, by utilizing light to direct fluid flow and particle motion. The field has seen significant growth recently,…

We present an optofluidic sensor based on an elastomeric two-dimensional (2D) grating integrated inside a hemispherical fluid chamber. Laser beam is diffracted before (reflection) and after (transmission) going through the grating and…

Optics · Physics 2014-02-10 Zhida Xu , Logan Liu

In this work, all-silicon, integrated optofluidic platforms, fabricated by electrochemical micromachining technology, making use of vertical, one-dimensional high-aspect- ratio photonic crystals for flow-through (bio)sensing applications…

Optics · Physics 2015-10-20 Giuseppe Barillaro

Optical fibre-based sensors measuring refractive index shift in bodily fluids and tissues are versatile and accurate probes of physiological processes. Here, we suggest a refractive index sensor based on a microstructured exposed-core fibre…

Lab-on-a-chip (LOC) forms the basis of the new-generation portable analytical systems. LOC allows the manipulation of ultralow flows of liquid reagents and multistep reactions on a microfluidic chip, which requires a robust and precise…

We present an optomechanical device platform for characterization of optical, thermal, and rheological properties of fluids on the micron scale. A suspended silicon microdisk resonator with a vibrating mass of 100 fg and an effective…

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