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Codes in the Damerau--Levenshtein metric have been extensively studied recently owing to their applications in DNA-based data storage. In particular, Gabrys, Yaakobi, and Milenkovic (2017) designed a length-$n$ code correcting a single…

Information Theory · Computer Science 2023-06-30 Shuche Wang , Van Khu Vu , Vincent Y. F. Tan

Regenerating codes are efficient methods for distributed storage in storage networks, where node failures are common. They guarantee low cost data reconstruction and repair through accessing only a predefined number of arbitrarily chosen…

Information Theory · Computer Science 2017-11-09 Kaveh Mahdaviani , Ashish Khisti , Soheil Mohajer

In this paper, we study the Random Access Problem in DNA storage, which addresses the challenge of retrieving a specific information strand from a DNA-based storage system. In this framework, the data is represented by $k$ information…

Information Theory · Computer Science 2025-08-26 Avital Boruchovsky , Ohad Elishco , Ryan Gabrys , Anina Gruica , Itzhak Tamo , Eitan Yaakobi

Biological data mainly comprises of Deoxyribonucleic acid (DNA) and protein sequences. These are the biomolecules which are present in all cells of human beings. Due to the self-replicating property of DNA, it is a key constitute of genetic…

Other Quantitative Biology · Quantitative Biology 2020-06-04 Shakeela Bibi , Javed Iqbal , Adnan Iftekhar , Mir Hassan

In this work we continue the study of a new class of codes, called \emph{codes over graphs}. Here we consider storage systems where the information is stored on the edges of a complete directed graph with $n$ nodes. The failure model we…

Information Theory · Computer Science 2017-09-15 Lev Yohananov , Eitan Yaakobi

Motivated by applications in DNA storage, we study a setting in which strings are affected by tandem-duplication errors. In particular, we look at two settings: disjoint tandem-duplication errors, and equal-length tandem-duplication errors.…

Information Theory · Computer Science 2024-01-10 Wenjun Yu , Moshe Schwartz

Due to the redundant nature of DNA synthesis and sequencing technologies, a basic model for a DNA storage system is a multi-draw "shuffling-sampling" channel. In this model, a random number of noisy copies of each sequence is observed at…

Information Theory · Computer Science 2021-12-06 Kel Levick , Reinhard Heckel , Ilan Shomorony

We consider the problem of constructing codes that can correct $\delta$ deletions occurring in an arbitrary binary string of length $n$ bits. Varshamov-Tenengolts (VT) codes, dating back to 1965, are zero-error single deletion $(\delta=1)$…

Information Theory · Computer Science 2018-05-25 Serge Kas Hanna , Salim El Rouayheb

We introduce the sum channel, a new channel model motivated by applications in distributed storage and DNA data storage. In the error-free case, it takes as input an $\ell$-row binary matrix and outputs an $(\ell+1)$-row matrix whose first…

Information Theory · Computer Science 2026-04-14 Lyan Abboud , Eitan Yaakobi

As DNA data storage moves closer to practical deployment, minimizing sequencing coverage depth is essential to reduce both operational costs and retrieval latency. This paper addresses the recently studied Random Access Problem, which…

Information Theory · Computer Science 2026-01-13 Chen Wang , Eitan Yaakobi

We consider $t$-Lee-error-correcting codes of length $n$ over the residue ring $\mathbb{Z}_m := \mathbb{Z}/m\mathbb{Z}$ and determine upper and lower bounds on the number of $t$-Lee-error-correcting codes. We use two different methods,…

Information Theory · Computer Science 2023-05-11 Nadja Willenborg , Anna-Lena Horlemann , Violetta Weger

This paper presents and analyzes a novel concatenated coding scheme for enabling error resilience in two distributed storage settings: one being storage using existing regenerating codes and the second being storage using locally repairable…

Information Theory · Computer Science 2013-12-12 Natalia Silberstein , Ankit Singh Rawat , Sriram Vishwanath

In this paper, we propose a novel iterative encoding algorithm for DNA storage to satisfy both the GC balance and run-length constraints using a greedy algorithm. DNA strands with run-length more than three and the GC balance ratio far from…

Information Theory · Computer Science 2023-01-04 Seong-Joon Park , Yongwoo Lee , Jong-Seon No

We consider network coding for networks experiencing worst-case bit-flip errors, and argue that this is a reasonable model for highly dynamic wireless network transmissions. We demonstrate that in this setup prior network error-correcting…

Information Theory · Computer Science 2011-08-16 Qiwen Wang , Sidharth Jaggi , Shuo-Yen Robert Li

Error-correcting codes resilient to synchronization errors such as insertions and deletions are known as insdel codes. Due to their important applications in DNA storage and computational biology, insdel codes have recently become a focal…

Combinatorics · Mathematics 2024-08-21 Xiangliang Kong , Itzhak Tamo , Hengjia Wei

Synchronization errors, such as insertions and deletions, present a fundamental challenge in DNA-based data storage systems, arising from both synthesis and sequencing noise. These channels are often modeled as…

Information Theory · Computer Science 2025-06-23 Ziv Aharoni , Henry D. Pfister

The short lifespan of traditional data storage media, coupled with an exponential increase in storage demand, has made long-term archival a fundamental problem in the data storage industry and beyond. Consequently, researchers are looking…

Image and Video Processing · Electrical Eng. & Systems 2026-03-06 Xavier Pic , Nimesh Pinnamaneni , Raja Appuswamy

The biochemical processes underlying DNA data storage, including synthesis, amplification, and sequencing, are inherently noisy. Consequently, base-level insertion, deletion, and substitution (IDS) errors, as well as sequence-level…

Information Theory · Computer Science 2026-03-17 Ramy Khabbaz , Jérémy Mateos , Marc Antonini , Serge Kas Hanna

DNA computing, a nontraditional computing mechanism, provides a feasible and effective method for solving NP-hard problems because of the vast parallelism and high-density storage of DNA molecules. Although DNA computing has been exploited…

Molecular Networks · Quantitative Biology 2022-11-17 Enqiang Zhu , Xianhang Luo , Chanjuan Liu , Xiaolong Shi , Jin Xu

DNA has many valuable characteristics that make it suitable for a long-term storage medium, in particular its durability and high information density. DNA can be stored safely for hundreds of years with virtually no degradation, in contrast…

Quantitative Methods · Quantitative Biology 2022-05-31 Jamie J. Alnasir , Thomas Heinis , Louis Carteron