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One of the challenges in the development of patient-specific models of cardiac arrhythmias for clinical applications has been accounting for myocardial fiber organization. The fiber varies significantly from heart to heart, but cannot be…

Medical Physics · Physics 2023-07-22 Jiyue He , Arkady Pertsov , John Bullinga , Rahul Mangharam

We propose FiberNet, a method to estimate \emph{in-vivo} the cardiac fiber architecture of the human atria from multiple catheter recordings of the electrical activation. Cardiac fibers play a central role in the electro-mechanical function…

Image and Video Processing · Electrical Eng. & Systems 2022-07-25 Carlos Ruiz Herrera , Thomas Grandits , Gernot Plank , Paris Perdikaris , Francisco Sahli Costabal , Simone Pezzuto

The anisotropic structure of the myocardium is a key determinant of the cardiac function. To date, there is no imaging modality to assess in-vivo the cardiac fiber structure. We recently proposed Fibernet, a method for the automatic…

Machine Learning · Computer Science 2024-11-01 Efraín Magaña , Simone Pezzuto , Francisco Sahli Costabal

Electroanatomical maps are a key tool in the diagnosis and treatment of atrial fibrillation. Current approaches focus on the activation times recorded. However, more information can be extracted from the available data. The fibers in…

Integrating spatial information about atrial physiology and anatomy in a single patient from multimodal datasets, as well as generalizing these data across patients, requires a common coordinate system. In the atria, this is challenging due…

While ventricular electromechanics is extensively studied, four-chamber heart models have only been addressed recently; most of these works however neglect atrial contraction. Indeed, as atria are characterized by a complex physiology…

Rule-based methods are often used for assigning fiber orientation to cardiac anatomical models. However, existing methods have been developed using data mostly from the left ventricle. As a consequence, fiber information obtained from…

Over the past two decades there has been a steady trend towards the development of realistic models of cardiac conduction with increasing levels of detail. However, making models more realistic complicates their personalization and use in…

This review focuses on the computerized modeling of the electrophysiology of the human atria, emphasizing the simulation of common arrhythmias such as atrial flutter (AFlut) and atrial fibrillation (AFib). Which components of the model are…

Computational Physics · Physics 2025-05-30 Olaf Dössel , Axel Loewe

Atrial arrhythmia can be categorized into tachycardia, flutter, and fibrillation. Atrial fibrillation is a prevalent heart disease that results in weak and irregular contractions of the atria. It affects millions people worldwide and…

Medical Physics · Physics 2024-02-01 Jiyue He

Atrial fibrillation is a heart rhythm disorder that affects tens of millions people worldwide. The most effective treatment is catheter ablation. This involves irreversible heating of abnormal cardiac tissue facilitated by electroanatomical…

Medical Physics · Physics 2022-11-01 Jiyue He , Arkady Pertsov , Sanjay Dixit , Katie Walsh , Eric Toolan , Rahul Mangharam

Atrial Fibrillation is a heart condition characterized by erratic heart rhythms caused by chaotic propagation of electrical impulses in the atria, leading to numerous health complications. State-of-the-art models employ complex algorithms…

Quantitative Methods · Quantitative Biology 2019-12-02 Paul Samuel Ignacio , David Uminsky , Christopher Dunstan , Esteban Escobar , Luke Trujillo

Electroanatomical mapping, a keystone diagnostic tool in cardiac electrophysiology studies, can provide high-density maps of the local electric properties of the tissue. It is therefore tempting to use such data to better individualize…

Optimization and Control · Mathematics 2021-02-03 Thomas Grandits , Simone Pezzuto , Jolijn M. Lubrecht , Thomas Pock , Gernot Plank , Rolf Krause

Electroanatomical mapping is a technique used in cardiology to create a detailed 3D map of the electrical activity in the heart. It is useful for diagnosis, treatment planning and real time guidance in cardiac ablation procedures to treat…

Image and Video Processing · Electrical Eng. & Systems 2023-11-29 Sunil Mathew , Jasbir Sra , Daniel B. Rowe

The aim of this study is to use image-processing techniques developed in the field of astrophysics as inspiration for a novel approach to the three-dimensional (3D) imaging of periprocedural medical data, with the intention of providing…

Medical Physics · Physics 2019-02-05 I. Brewis , J. A. McLaughlin

Left atrial voltage maps are routinely acquired during electroanatomic mapping in patients undergoing catheter ablation for atrial fibrillation. For patients, who have prior catheter ablation when they are in sinus rhythm, the voltage map…

Medical Physics · Physics 2022-11-10 Jiyue He , Kuk Jin Jang , Katie Walsh , Jackson Liang , Sanjay Dixit , Rahul Mangharam

Image-based, patient-specific modelling of hemodynamics can improve diagnostic capabilities and provide complementary insights to better understand the hemodynamic treatment outcomes. However, computational fluid dynamics simulations remain…

Numerical Analysis · Mathematics 2025-02-18 Francesco Romor , Felipe Galarce , Jan Brüning , Leonid Goubergrits , Alfonso Caiazzo

Image-based computational models of the heart represent a powerful tool to shed new light on the mechanisms underlying physiological and pathological conditions in cardiac function and to improve diagnosis and therapy planning. However, in…

Tissues and Organs · Quantitative Biology 2021-01-15 Laura Marx , Justyna A. Niestrawska , Matthias A. F. Gsell , Federica Caforio , Gernot Plank , Christoph M. Augustin

This work presents a novel approach for characterizing the mechanical behavior of atrial tissue using constitutive neural networks. Based on experimental biaxial tensile test data of healthy human atria, we automatically discover the most…

Computational Engineering, Finance, and Science · Computer Science 2025-04-04 Mathias Peirlinck , Kevin Linka , Ellen Kuhl

Mapping resolution has recently been identified as a key limitation in successfully locating the drivers of atrial fibrillation. Using a simple cellular automata model of atrial fibrillation, we demonstrate a method by which re-entrant…

Tissues and Organs · Quantitative Biology 2020-01-27 Max Falkenberg McGillivray , William Cheng , Nicholas S. Peters , Kim Christensen
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