Related papers: Oscillations in a white blood cell production mode…
Hematopoiesis is a complex biological process that leads to the production and regulation of blood cells. It is based upon differentiation of stem cells under the action of growth factors. A mathematical approach of this process is proposed…
We analyze the asymptotic stability of a nonlinear system of two differential equations with delay describing the dynamics of blood cell production. This process takes place in the bone marrow where stem cells differentiate throughout…
We study a mathematical model describing the dynamics of a pluripotent stem cell population involved in the blood production process in the bone marrow. This model is a differential equation with a time delay. The delay describes the cell…
We study the emergence of periodic oscillations through a Hopf bifurcation in a scalar diffusion equation on the half line coupled to a dynamic boundary condition. Our results quantify the effect of delay through the buffering in the…
We investigate a diffusive, stage-structured epidemic model with the maturation delay and freely-moving delay. Choosing delays and diffusive rates as bifurcation parameters, the only possible way to destabilize the endemic equilibrium is…
This work investigates the emergence of oscillations in one of the simplest cellular signaling networks exhibiting oscillations, namely, the dual-site phosphorylation and dephosphorylation network (futile cycle), in which the mechanism for…
We study a nonlinear PDE problem motivated by the peculiar patterns arising in myxobacteria, namely counter-migrating cell density waves. We rigorously prove the existence of Hopf bifurcations for some specific values of the parameters of…
Gene regulatory networks, i.e. DNA segments in a cell which interact with each other indirectly through their RNA and protein products, lie at the heart of many important intracellular signal transduction processes. In this paper we analyse…
Double Hopf bifurcation analysis can be used to reveal some complicated dynamical behavior in a dynamical system, such as the existence or coexistence of periodic orbits, quasi-periodic orbits, or even chaos. In this paper, an algorithm for…
Singular Hopf bifurcation occurs in generic families of vector-fields with two slow variables and one fast variable. Normal forms for this bifurcation depend upon several parameters, and the dynamics displayed by the normal forms is…
On base of Hamiltonian formalism, we show that Hopf bifurcation arrives, in the course of the system evolution, at creation of revolving region of the phase plane being bounded by limit cycle. A revolving phase plane with a set of limit…
We perform one and two-parameter numerical bifurcation analysis of a mechanotransduction model approximating the dynamics of mesenchymal stem cell differentiation into neurons, adipocytes, myocytes and osteoblasts. For our analysis, we use…
Protein phosphorylation cycles are important mechanisms of the post translational modification of a protein and as such an integral part of intracellular signaling and control. We consider the sequential phosphorylation and…
Dynamical properties of ultradiscrete Hopf bifurcation, similar to those of the standard Hopf bifurcation, are discussed by proposing a simple model of ultradiscrete equations with max-plus algebra. In ultradiscrete Hopf bifurcation, limit…
We develop a comprehensive mathematical model of platelet, megakaryocyte, and thrombopoietin dynamics in humans. We show that there is a single stationary solution that can undergo a Hopf bifurcation, and use this information to investigate…
Polymerization of microtubules is ubiquitous in biological cells and under certain conditions it becomes oscillatory in time. Here simple reaction models are analyzed that capture such oscillations as well as the length distribution of…
In a previous work we investigated the existence of Hopf degenerate bifurcation points for a differential delay equation modeling leukemia and we actually found Hopf points of codimension two for the considered problem. If around the…
We consider a model proposed by one of the authors for a type of plastic instability found in creep experiments which reproduces a number of experimentally observed features. The model consists of three coupled non-linear differential…
Hydrodynamic instabilities often cause spatio-temporal pattern formations and transitions between them. We investigate a model experimental system, a density oscillator, where the bifurcation from a resting state to an oscillatory state is…
A density oscillator exhibits limit-cycle oscillations driven by the density difference of the two fluids. We performed two-dimensional hydrodynamic simulations with a simple model, and reproduced the oscillatory flow observed in…