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Purpose: In this study, we present the creation of an anthropomorphic, head and neck, nuclear medicine phantom and its characterization for the validation of a Monte Carlo, SPECT image based, Iodine-131 RPT dosimetry workflow. Methods: 3D…

Purpose: To evaluate reliability of upright CT for proton dose calculation and feasibility of a simplified phantom configuration for accelerated routine QA. Methods: A calibration phantom was scanned on an upright CT following consensus…

The diverse near-Earth radiation environment due to cosmic rays and solar radiation has direct impact on human civilization. In the present and upcoming era of increasing air transfer, it is important to have precise idea of radiation dose…

Medical Physics · Physics 2021-12-16 Abhijit Roy , Ritabrata Sarkar , Choonsik Lee

The XCAT phantom is a realistic 4D digital torso phantom that is widely used in imaging and therapy research. However, lung mass is not conserved between respiratory phases of the phantom, making detailed dosimetric simulations and dose…

Purpose: To characterize image quality, imaging dose, and dose calculation accuracy for an upright CT scanner with a six-degree-of-freedom patient positioning system. Methods: Imaging dose (CTDIvol) was measured at 120 kVp and 200 mAs.…

Accurate proton dose calculation using Monte Carlo (MC) is computationally demanding in workflows like robust optimisation, adaptive replanning, and probabilistic inference, which require repeated evaluations. To address this, we develop a…

Machine Learning · Statistics 2025-09-24 Aaron Pim , Tristan Pryer

Monte Carlo (MC) simulation is commonly considered to be the most accurate dose calculation method in radiotherapy. However, its efficiency still requires improvement for many routine clinical applications. In this paper, we present our…

Medical Physics · Physics 2015-05-28 Xun Jia , Xuejun Gu , Yan Jiang Graves , Michael Folkerts , Steve B. Jiang

Purpose: To develop and evaluate DosimeTron, an agentic AI system for automated patient-specific MC internal radiation dosimetry in PET/CT examinations. Materials and Methods: In this retrospective study, DosimeTron was evaluated on a…

Medical Physics · Physics 2026-04-09 Eleftherios Tzanis , Michail E. Klontzas , Antonios Tzortzakakis

This paper describes the development and validation of a Monte Carlo (MC) dose computing module dedicated to organ dose calculations of patients undergoing nuclear medicine (NM) internal radiation exposures involving 18F-FDG PET/CT…

Medical Physics · Physics 2022-03-30 Zhao Peng , Yu Lu , Yao Xu , Yongzhe Li , Bo Cheng , Ming Ni , Zhi Chen , Xi Pei , Qiang Xie , Shicun Wang , X. George Xu

Monte Carlo (MC) method has been recognized the most accurate dose calculation method for radiotherapy. However, its extremely long computation time impedes clinical applications. Recently, a lot of efforts have been made to realize fast MC…

Medical Physics · Physics 2017-02-08 Zhen Tian , Feng Shi , Michael Folkerts , Nan Qin , Steve B. Jiang , Xun Jia

A novel dose calculation approach was designed based on the application of LSTM network that processes the 3D patient/phantom geometry as a sequence of 2D computed tomography input slices yielding a corresponding sequence of 2D slices that…

Medical Physics · Physics 2021-06-09 Ahmad Neishabouri , Niklas Wahl , Ulrich Köthe , Mark Bangert

Space radiation remains one of the primary hazards to spaceflight crews. The unique nature of the intravehicular radiation spectrum makes prediction of biological outcomes difficult, with computational simulation-based efforts stymied by…

Medical Physics · Physics 2023-08-24 Chesal MA , Blue RS , Aunon-Chancellor SA , Chancellor JC

Two full rotating gantry with different nozzles (Multipurpose nozzle with MLC, Scanning Dedicated nozzle) with conventional cyclotron system is installed and under commissioning for various proton treatment options at Samsung Medical Center…

Computed Tomography (CT) measures the attenuation coefficient of an object and converts the value assigned to each voxel into a CT number. In radiation therapy, CT number, which is directly proportional to the linear attenuation…

Medical Physics · Physics 2015-03-13 Dong Joo Rhee , Sung-woo Kim , Young Min Moon , Jung Ki Kim , Dong Hyeok Jeong

Due to the increasing complexity of radiotherapy delivery, accurate dose verification has become an essential part of the clinical treatment process. The purpose of this work was to develop an electronic portal image (EPI) based…

Medical Physics · Physics 2015-06-17 Reid W Townson , Sergei Zavgorodni

This paper consists of two parts.In the first part, the scatter components of computed tomograpahy dose profiles are modeled using various functions including the solution to Riccati's differential equation. These scatter functions are…

Medical Physics · Physics 2016-06-29 Victor J. Weir

Accurate dose calculation on cone beam computed tomography (CBCT) images is essential for modern proton treatment planning workflows, particularly when accounting for inter-fractional anatomical changes in adaptive treatment scenarios.…

Adaptive Radiation Therapy (ART) was developed based on Image-guided Radiation Therapy (IGRT) and it is the trend of photon radiation therapy. To get a better use of Cone Beam CT (CBCT) images for ART, the CBCT system model was established…

Medical Physics · Physics 2014-08-21 Yu Wang , Chaobin Chen , Ruifen Cao , Liqin Hu , Bingbing Li

Purpose: To obtain individualized internal doses with a Monte Carlo method in patients undergoing diagnostic FCH-PET studies and to compare such doses with the MIRD method calculations. Methods: A patient cohort of 17 males were imaged…

Treatment planning system calculations in inhomogeneous regions may present significant inaccuracies due to loss of electronic equilibrium. In this study, three different dose calculation algorithms, pencil beam, collapsed cone, and…

Medical Physics · Physics 2015-03-12 Sung Jin Kim , Dong Ho Kim , Sung Kyu Kim