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Measuring similarity between incomplete data is a fundamental challenge in web mining, recommendation systems, and user behavior analysis. Traditional approaches either discard incomplete data or perform imputation as a preprocessing step,…

Machine Learning · Computer Science 2025-10-16 Yang Cao , Sikun Yang , Kai He , Wenjun Ma , Ming Liu , Yujiu Yang , Jian Weng

Machine-learning models that learn from data to predict how protein sequence encodes function are emerging as a useful protein engineering tool. However, when using these models to suggest new protein designs, one must deal with the vast…

Quantitative Methods · Quantitative Biology 2021-07-07 Brian L. Hie , Kevin K. Yang

Zero-shot learning (ZSL) aims to recognize objects of novel classes without any training samples of specific classes, which is achieved by exploiting the semantic information and auxiliary datasets. Recently most ZSL approaches focus on…

Computer Vision and Pattern Recognition · Computer Science 2018-07-25 Huajie Jiang , Ruiping Wang , Shiguang Shan , Xilin Chen

To avoid the exhaustive search over locations and scales, current state-of-the-art object detection systems usually involve a crucial component generating a batch of candidate object proposals from images. In this paper, we present a simple…

Computer Vision and Pattern Recognition · Computer Science 2018-07-31 Tianshui Chen , Liang Lin , Xian Wu , Nong Xiao , Xiaonan Luo

We introduce Matched Machine Learning, a framework that combines the flexibility of machine learning black boxes with the interpretability of matching, a longstanding tool in observational causal inference. Interpretability is paramount in…

Methodology · Statistics 2023-04-05 Marco Morucci , Cynthia Rudin , Alexander Volfovsky

Computational approaches to drug discovery can reduce the time and cost associated with experimental assays and enable the screening of novel chemotypes. Structure-based drug design methods rely on scoring functions to rank and predict…

Machine Learning · Statistics 2020-10-19 Matthew Ragoza , Joshua Hochuli , Elisa Idrobo , Jocelyn Sunseri , David Ryan Koes

Most of the existing approaches focus on specific visual tasks while ignoring the relations between them. Estimating task relation sheds light on the learning of high-order semantic concepts, e.g., transfer learning. How to reveal the…

Machine Learning · Computer Science 2019-07-30 Guangcong Wang , Jianhuang Lai , Wenqi Liang , Guangrun Wang

A novel approach for structure alignment is presented, where the key ingredients are: (1) An error function formulation of the problem simultaneously in terms of binary (Potts) assignment variables and real-valued atomic coordinates. (2)…

Biological Physics · Physics 2007-05-23 M. Ohlsson , C. Peterson , M. Ringner , R. Blankenbecler

Compound-protein pairs dominate FDA-approved drug-target pairs and the prediction of compound-protein affinity and contact (CPAC) could help accelerate drug discovery. In this study we consider proteins as multi-modal data including 1D…

Biomolecules · Quantitative Biology 2020-12-02 Yuning You , Yang Shen

Transformer-based large language models have remarkable potential to accelerate design optimization for applications such as drug development and materials discovery. Self-supervised pretraining of transformer models requires large-scale…

Machine Learning · Computer Science 2023-10-27 Pei Zhang , Logan Kearney , Debsindhu Bhowmik , Zachary Fox , Amit K. Naskar , John Gounley

Object rearrangement has recently emerged as a key competency in robot manipulation, with practical solutions generally involving object detection, recognition, grasping and high-level planning. Goal-images describing a desired scene…

Robotics · Computer Science 2021-11-16 Walter Goodwin , Sagar Vaze , Ioannis Havoutis , Ingmar Posner

Deep learning-based models have demonstrated remarkable success in solving illposed inverse problems; however, many fail to strictly adhere to the physical constraints imposed by the measurement process. In this work, we introduce a…

Machine Learning · Computer Science 2025-05-22 Jorge Bacca

The ability of a human being to extrapolate previously gained knowledge to other domains inspired a new family of methods in machine learning called transfer learning. Transfer learning is often based on the assumption that objects in both…

Machine Learning · Statistics 2016-10-21 Ievgen Redko , Younès Bennani

Due to the high inter-class similarity caused by the complex composition and the co-existing objects across scenes, numerous studies have explored object semantic knowledge within scenes to improve scene recognition. However, a resulting…

Computer Vision and Pattern Recognition · Computer Science 2024-08-06 Chuanxin Song , Hanbo Wu , Xin Ma , Yibin Li

Face recognition is a popular application of pat- tern recognition methods, and it faces challenging problems including illumination, expression, and pose. The most popular way is to learn the subspaces of the face images so that it could…

Computer Vision and Pattern Recognition · Computer Science 2014-02-25 Huanguo Zhang , Sha Lv , Wei Li , Xun Qu

During the recent years, correlation filters have shown dominant and spectacular results for visual object tracking. The types of the features that are employed in these family of trackers significantly affect the performance of visual…

Computer Vision and Pattern Recognition · Computer Science 2018-03-13 Erhan Gundogdu , A. Aydin Alatan

Orientation estimation is the core to a variety of vision and robotics tasks such as camera and object pose estimation. Deep learning has offered a way to develop image-based orientation estimators; however, such estimators often require…

Computer Vision and Pattern Recognition · Computer Science 2022-11-22 Brian Okorn , Chuer Pan , Martial Hebert , David Held

Background: A partially random target selection method was developed to design and produce affinity reagents (target) to any protein query. It is based on the recent concept of Proteomic Code (for review see Biro, 2007 [1]) which suggests…

Quantitative Methods · Quantitative Biology 2008-07-22 Jan C Biro

Accurate prediction of protein-ligand binding affinity is critical for drug discovery. While recent deep learning approaches have demonstrated promising results, they often rely solely on structural features of proteins and ligands,…

Machine Learning · Computer Science 2026-01-23 Han Liu , Keyan Ding , Peilin Chen , Yinwei Wei , Liqiang Nie , Dapeng Wu , Shiqi Wang

Accurate spatial understanding is essential for image-guided surgery, augmented reality integration and context awareness. In minimally invasive procedures, where visual input is the sole intraoperative modality, establishing precise…

Computer Vision and Pattern Recognition · Computer Science 2025-12-12 Alberto Rota , Elena De Momi
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