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Studies of the degrees of freedom or "synergies" in musculoskeletal systems rely critically on algorithms to estimate the "dimension" of kinematic or neural data. Linear algorithms such as principal component analysis (PCA) are used almost…

Quantitative Methods · Quantitative Biology 2007-05-23 Robert H. Clewley , John M. Guckenheimer , Francisco J. Valero-Cuevas

An important task for many if not all the scientific domains is efficient knowledge integration, testing and codification. It is often solved with model construction in a controllable computational environment. In spite of that, the…

Molecular Networks · Quantitative Biology 2018-11-06 Emilia M. Wysocka , Valery Dzutsati , Tirthankar Bandyopadhyay , Laura Condon , Sahil Garg

We investigate the transport properties of active particles undergoing a three-state run-and-tumble dynamics in one dimension, induced by non-reciprocal transition rates between self-propelling velocity states $\{-v, 0, +v\}$ that…

Statistical Mechanics · Physics 2025-08-15 Julio C. R. Romo-Cruz , Francisco J. Sevilla

Molecular Dynamics (MD) simulations of proteins implicitly contain the information connecting the atomistic molecular structure and proteins' biologically relevant motion, where large-scale fluctuations are deemed to guide folding and…

Biological Physics · Physics 2024-04-05 Eric Beyerle , Marina Guenza

Understanding neural dynamics is a central topic in machine learning, non-linear physics and neuroscience. However, the dynamics is non-linear, stochastic and particularly non-gradient, i.e., the driving force can not be written as gradient…

Neurons and Cognition · Quantitative Biology 2024-12-05 Junbin Qiu , Haiping Huang

We investigate finite size scaling aspects of disorder reaction-diffusion processes in one dimension utilizing both numerical and analytical approaches. The former averages the spectrum gap of the associated evolution operators by doubling…

Statistical Mechanics · Physics 2009-06-27 M. D. Grynberg , G. L. Rossini , R. B. Stinchcombe

In this work, we study the problem of learning partially observed linear dynamical systems from a single sample trajectory. A major practical challenge in the existing system identification methods is the undesirable dependency of their…

Machine Learning · Computer Science 2020-10-09 Salar Fattahi

We introduce a nonlinear stochastic model reduction technique for high-dimensional stochastic dynamical systems that have a low-dimensional invariant effective manifold with slow dynamics, and high-dimensional, large fast modes. Given only…

Machine Learning · Statistics 2023-10-25 Felix X. -F. Ye , Sichen Yang , Mauro Maggioni

In this paper, we propose a novel Local Macroscopic Conservative (LoMaC) low rank tensor method for simulating the Vlasov-Poisson (VP) system. The LoMaC property refers to the exact local conservation of macroscopic mass, momentum and…

Numerical Analysis · Mathematics 2022-07-04 Wei Guo , Jing-Mei Qiu

The efficient calculation of rare-event kinetics in complex dynamical systems, such as the rate and pathways of ligand dissociation from a protein, is a generally unsolved problem. Markov state models can systematically integrate ensembles…

Chemical Physics · Physics 2016-02-03 Benjamin Trendelkamp-Schroer , Frank Noe

Task and Motion Planning (TAMP) integrates high-level task planning with low-level motion feasibility, but existing methods are costly in long-horizon problems due to excessive motion sampling. While LLMs provide commonsense priors, they…

Robotics · Computer Science 2026-03-06 Minseo Kwon , Young J. Kim

The theoretical investigation of non-adiabatic processes is hampered by the complexity of the coupled electron-nuclear dynamics beyond the Born-Oppenheimer approximation. Classically, the simulation of such reactions is limited by the…

Quantum Physics · Physics 2021-01-06 Pauline J. Ollitrault , Guglielmo Mazzola , Ivano Tavernelli

Non-equilibrium Markov State Modeling (MSM) has recently been proposed [Phys. Rev. E 94, 053001 (2016)] as a possible route to construct a physical theory of sliding friction from a long steady state atomistic simulation: the approach…

Statistical Mechanics · Physics 2017-10-17 M. Teruzzi , F. Pellegrini , A. Laio , E. Tosatti

A key issue in dimension reduction of dissipative dynamical systems with spectral gaps is the identification of slow invariant manifolds. We present theoretical and numerical results for a variational approach to the problem of computing…

Dynamical Systems · Mathematics 2012-11-30 Dirk Lebiedz , Jochen Siehr , Jonas Unger

The theory of large deviations has been applied successfully in the last 30 years or so to study the properties of equilibrium systems and to put the foundations of equilibrium statistical mechanics on a clearer and more rigorous footing. A…

Statistical Mechanics · Physics 2018-09-14 Hugo Touchette , Rosemary J. Harris

We present a dynamic subspace approach for efficiently approximating large-scale systems by learning time-continuous trajectories on the Grassmannian manifold. By parameterizing a low-dimensional basis as a geodesic path, the method allows…

Numerical Analysis · Mathematics 2026-05-26 Jack DeChant , Rudy Geelen , Shane A. McQuarrie , Johann Guilleminot

We consider an optimization problem related to semi-active damping of vibrating systems. The main problem is to determine the best damping matrix able to minimize influence of the input on the output of the system. We use a minimization…

Dynamical Systems · Mathematics 2017-07-07 Zoran Tomljanović , Christopher Beattie , Serkan Gugercin

In this paper we consider a biased velocity jump process with excluded-volume interactions for chemotaxis, where we account for the size of each particle. Starting with a system of N individual hard rod particles in one dimension, we derive…

Biological Physics · Physics 2020-03-04 Tertius Ralph , Stephen W. Taylor , Maria Bruna

Strong coupling between a system and its environment leads to the emergence of non-Markovian dynamics, which cannot be described by a time-local master equation. One way to capture such dynamics is to use numerical real-time path integrals,…

Mesoscale and Nanoscale Physics · Physics 2017-11-29 Aidan Strathearn , Brendon W. Lovett , Peter Kirton

We review recent developments in the theory of quantum dynamics in ultra-cold atomic physics, including exact techniques, but focusing on methods based on phase-space mappings that are appli- cable when the complexity becomes exponentially…