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Protein-protein interactions (PPIs) are of fundamental importance for the human body, and the knowledge of their existence can facilitate very important tasks like drug target developing and therapy design. The high-throughput experiments…

Molecular Networks · Quantitative Biology 2019-10-11 Andrea Moscatelli

This paper introduces Multi-population Ensemble Genetic Programming (MEGP), a computational intelligence framework that integrates cooperative coevolution and the multiview learning paradigm to address classification challenges in…

Neural and Evolutionary Computing · Computer Science 2025-09-25 Mohammad Sadegh Khorshidi , Navid Yazdanjue , Hassan Gharoun , Mohammad Reza Nikoo , Fang Chen , Amir H. Gandomi

Over the last couple of decades, Social Networks have connected people on the web from across the globe and have become a crucial part of our daily life. These networks have also rapidly grown as platforms for propagating products, ideas,…

Social and Information Networks · Computer Science 2022-11-23 Aaryan Gupta , Inder Khatri , Arjun Choudhry , Sanjay Kumar

Communities are subsets of a network that are densely connected inside and share only few connections to the rest of the network. The aim of this research is the development and evaluation of an efficient algorithm for detection of…

Social and Information Networks · Computer Science 2014-09-29 Jan Dreier

The identification of essential proteins can help in understanding the minimum requirements for cell survival and development. Network-based centrality approaches are commonly used to identify essential proteins from protein-protein…

Computational Engineering, Finance, and Science · Computer Science 2023-11-13 Li Pan , Haoyue Wang , Jing Sun , Bin Li , Bo Yang , Wenbin Li

Currently, we are overwhelmed by a deluge of experimental data, and network physics has the potential to become an invaluable method to increase our understanding of large interacting datasets. However, this potential is often unrealized…

Data Analysis, Statistics and Probability · Physics 2017-10-30 Juyong Lee , Steven P. Gross , Jooyoung Lee

Community detection, which identifies densely connected node clusters with sparse between-group links, is vital for analyzing network structure and function in real-world systems. Most existing community detection methods based on GCNs…

Social and Information Networks · Computer Science 2026-03-04 Gaofeng Zhou , Rui-Feng Wang , Kangning Cui

Predicting protein interactions is one of the more interesting challenges of the post-genomic era. Many algorithms address this problem as a binary classification problem: given two proteins represented as two vectors of features, predict…

Molecular Networks · Quantitative Biology 2011-11-01 Ossnat Bar-Shira , Gal Chechik

Co-expression network is a critical technique for the identification of inter-gene interactions, which usually relies on all-pairs correlation (or similar measure) computation between gene expression profiles across multiple samples.…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-09-28 Yongchao Liu , Tony Pan , Srinivas Aluru

Accurate identification of bioactive peptides (BPs) and protein post-translational modifications (PTMs) is essential for understanding protein function and advancing therapeutic discovery. However, most computational methods remain limited…

Machine Learning · Computer Science 2025-12-05 Jixiu Zhai , Zikun Wang , Chupei Tang , Haitian Zhong , Ziyang Xu , Yuhuan Liu , Shengrui Xu , Jingwan Wang , Dan Huang , Tianchi Lu

Community detection is an important task in network analysis. A community (also referred to as a cluster) is a set of cohesive vertices that have more connections inside the set than outside. In many social and information networks, these…

Social and Information Networks · Computer Science 2015-04-06 Joyce Jiyoung Whang , David F. Gleich , Inderjit S. Dhillon

A fundamental problem in the analysis of network data is the detection of network communities, groups of densely interconnected nodes, which may be overlapping or disjoint. Here we describe a method for finding overlapping communities based…

Social and Information Networks · Computer Science 2015-03-19 Brian Ball , Brian Karrer , M. E. J. Newman

Many complex networks display a mesoscopic structure with groups of nodes sharing many links with the other nodes in their group and comparatively few with nodes of different groups. This feature is known as community structure and encodes…

Physics and Society · Physics 2009-07-31 Andrea Lancichinetti , Santo Fortunato

The community plays a crucial role in understanding user behavior and network characteristics in social networks. Some users can use multiple social networks at once for a variety of objectives. These users are called overlapping users who…

Social and Information Networks · Computer Science 2024-05-08 Ziqing Zhu , Guan Yuan , Tao Zhou , Jiuxin Cao

Computational protein design (CPD) refers to the use of computational methods to design proteins. Traditional methods relying on energy functions and heuristic algorithms for sequence design are inefficient and do not meet the demands of…

Machine Learning · Computer Science 2024-10-30 Xiaoqi Ling , Cheng Cai , Demin Kong , Zhisheng Wei , Jing Wu , Lei Wang , Zhaohong Deng

Accurately predicting complex protein-protein interactions (PPIs) is crucial for decoding biological processes, from cellular functioning to disease mechanisms. However, experimental methods for determining PPIs are computationally…

Peptides play a pivotal role in a wide range of biological activities through participating in up to 40% protein-protein interactions in cellular processes. They also demonstrate remarkable specificity and efficacy, making them promising…

Biomolecules · Quantitative Biology 2024-02-09 Song Yin , Xuenan Mi , Diwakar Shukla

Community detection in social network graphs plays a vital role in uncovering group dynamics, influence pathways, and the spread of information. Traditional methods focus primarily on graph structural properties, but recent advancements in…

Social and Information Networks · Computer Science 2025-08-01 Ekta Gujral , Apurva Sinha

Complex networks considering both positive and negative links have gained considerable attention during the past several years. Community detection is one of the main challenges for complex network analysis. Most of the existing algorithms…

Social and Information Networks · Computer Science 2014-03-28 Yi Chen , Xiao-long Wang , Bo Yuan , Bu-zhou Tang