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Quantitative Systems Pharmacology (QSP) modeling is essential for drug development but it requires significant time investment that limits the throughput of domain experts. We present \textbf{GRASP} -- a multi-agent, graph-reasoning…

Machine Learning · Computer Science 2025-12-08 Omid Bazgir , Vineeth Manthapuri , Ilia Rattsev , Mohammad Jafarnejad

There has been significant success in designing highly efficient algorithms for distance and shortest-path queries in recent years; many of the state-of-the-art algorithms use the hub labeling framework. In this paper, we study the…

Data Structures and Algorithms · Computer Science 2016-11-22 Haris Angelidakis , Yury Makarychev , Vsevolod Oparin

The graph isomorphism problem asks whether two graphs are identical up to vertex relabeling. While the exact problem admits quasi-polynomial-time classical algorithms, many applications in molecular comparison, noisy network analysis, and…

Quantum Physics · Physics 2026-03-31 Prateek P. Kulkarni

We design new algorithms for approximating 2CSPs on graphs with bounded threshold rank, that is, whose normalized adjacency matrix has few eigenvalues larger than $\varepsilon$, smaller than $-\varepsilon$, or both. Unlike on worst-case…

Data Structures and Algorithms · Computer Science 2025-11-17 Prashanti Anderson , Samuel B. Hopkins , Amit Rajaraman , David Steurer

We aim to find orientations of mixed graphs optimizing the total reachability, a problem that has applications in causality and biology. For given a digraph $D$, we use $P(D)$ for the set of ordered pairs of distinct vertices in $V(D)$ and…

Computational Complexity · Computer Science 2025-09-24 Florian Hörsch

Query evaluation over probabilistic databases is known to be intractable in many cases, even in data complexity, i.e., when the query is fixed. Although some restrictions of the queries [19] and instances [4] have been proposed to lower the…

Databases · Computer Science 2019-08-28 Antoine Amarilli , Mikaël Monet , Pierre Senellart

Graph embedding learns low-dimensional representations for nodes in a graph and effectively preserves the graph structure. Recently, a significant amount of progress has been made toward this emerging research area. However, there are…

Machine Learning · Computer Science 2019-05-20 Yuan Yin , Zhewei Wei

With the surging popularity of approximate near-neighbor search (ANNS), driven by advances in neural representation learning, the ability to serve queries accompanied by a set of constraints has become an area of intense interest. While the…

Information Retrieval · Computer Science 2023-08-30 Gaurav Gupta , Jonah Yi , Benjamin Coleman , Chen Luo , Vihan Lakshman , Anshumali Shrivastava

Many resource allocation problems in the cloud can be described as a basic Virtual Network Embedding Problem (VNEP): the problem of finding a mapping of a request graph (describing a workload) onto a substrate graph (describing the physical…

Networking and Internet Architecture · Computer Science 2018-03-29 Matthias Rost , Stefan Schmid

Answer set programming (ASP) is a popular nonmonotonic-logic based paradigm for knowledge representation and solving combinatorial problems. Computing the answer set of an ASP program is NP-hard in general, and researchers have been…

Artificial Intelligence · Computer Science 2021-04-06 Fang Li , Huaduo Wang , Gopal Gupta

GQL has recently emerged as the standard query language over graph databases (particularly, the property graph model). Indeed, this is analogous to the role of SQL for relational databases. Unlike SQL, however, fundamental problems…

Databases · Computer Science 2025-10-23 Diego Figueira , Anthony W. Lin , Liat Peterfreund

For a given collection G of directed graphs we define the join-reachability graph of G, denoted by J(G), as the directed graph that, for any pair of vertices a and b, contains a path from a to b if and only if such a path exists in all…

Data Structures and Algorithms · Computer Science 2010-12-23 Loukas Georgiadis , Stavros D. Nikolopoulos , Leonidas Palios

Despite 25 years of research in academia, approximate query processing (AQP) has had little industrial adoption. One of the major causes of this slow adoption is the reluctance of traditional vendors to make radical changes to their legacy…

Databases · Computer Science 2018-11-09 Yongjoo Park , Barzan Mozafari , Joseph Sorenson , Junhao Wang

We witness an unprecedented proliferation of knowledge graphs that record millions of entities and their relationships. While knowledge graphs are structure-flexible and content rich, they are difficult to use. The challenge lies in the gap…

Databases · Computer Science 2013-11-12 Nandish Jayaram , Arijit Khan , Chengkai Li , Xifeng Yan , Ramez Elmasri

Solving point-wise feature correspondence in visual data is a fundamental problem in computer vision. A powerful model that addresses this challenge is to formulate it as graph matching, which entails solving a Quadratic Assignment Problem…

Computer Vision and Pattern Recognition · Computer Science 2024-10-23 Yongqing Liang , Huijun Han , Xin Li

Users are tapping into massive, heterogeneous entity graphs for many applications. It is challenging to select entity graphs for a particular need, given abundant datasets from many sources and the oftentimes scarce information for them. We…

Databases · Computer Science 2016-05-05 Ning Yan , Sona Hasani , Abolfazl Asudeh , Chengkai Li

Are users of an online social network interested equally in all connections in the network? If not, how can we obtain a summary of the network personalized to specific users? Can we use the summary for approximate query answering? As…

Databases · Computer Science 2022-03-29 Shinhwan Kang , Kyuhan Lee , Kijung Shin

We study the knapsack problem with graph theoretic constraints. That is, we assume that there exists a graph structure on the set of items of knapsack and the solution also needs to satisfy certain graph theoretic properties on top of…

Data Structures and Algorithms · Computer Science 2024-01-25 Palash Dey , Sudeshna Kolay , Sipra Singh

Approximate nearest neighbor (ANN) search in high-dimensional Euclidean space has a broad range of applications. Among existing ANN algorithms, graph-based methods have shown superior performance in terms of the time-accuracy trade-off.…

Databases · Computer Science 2024-11-20 Yutong Gou , Jianyang Gao , Yuexuan Xu , Cheng Long

Computing shortest paths is a fundamental operation in processing graph data. In many real-world applications, discovering shortest paths between two vertices empowers us to make full use of the underlying structure to understand how…

Databases · Computer Science 2021-04-21 Ye Wang , Qing Wang , Henning Koehler , Yu Lin
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