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Observing retinal fundus images by an ophthalmologist is a major diagnosis approach for glaucoma. However, it is still difficult to distinguish the features of the lesion solely through manual observations, especially, in glaucoma early…

Image and Video Processing · Electrical Eng. & Systems 2020-01-08 Peng Liu , Ruogu Fang

Effectively stratifying patient risk in chronic diseases like glaucoma is a major clinical challenge. Clinicians need tools to identify patients at high risk of progression from sparse and irregularly-sampled electronic health records…

Machine Learning · Computer Science 2026-05-04 Bruce Rushing , Angela Danquah , Alireza Namazi , Arjun Dirghangi , Heman Shakeri

Glaucoma is a complex group of eye diseases marked by optic nerve damage, commonly linked to elevated intraocular pressure and biomarkers like retinal nerve fiber layer thickness. Understanding how these biomarkers interact is crucial for…

Image and Video Processing · Electrical Eng. & Systems 2025-09-24 Cheng Huang , Weizheng Xie , Tsengdar Lee , Karanjit Kooner , Ning Zhang , Jia Zhang

Falls are a leading cause of injury and loss of independence among older adults. Vision-based fall prediction systems offer a non-invasive solution to anticipate falls seconds before impact, but their development is hindered by the scarcity…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Md Fokhrul Islam , Sajeda Al-Hammouri , Christopher J. Arellano , Kavan Hazeli , Heman Shakeri

Identifying change points (CPs) in a time series is crucial to guide better decision making across various fields like finance and healthcare and facilitating timely responses to potential risks or opportunities. Existing Change Point…

Machine Learning · Computer Science 2023-06-09 Kopal Garg , Jennifer Yu , Tina Behrouzi , Sana Tonekaboni , Anna Goldenberg

We describe a multispeckle dynamic light scattering technique capable of resolving the motion of scattering sites in cases that this motion changes systematically with time. The method is based on the visibility of the speckle pattern…

Soft Condensed Matter · Physics 2007-05-23 R. Bandyopadhyay , A. S. Gittings , S. S. Suh , P. K. Dixon , D. J. Durian

Change-point detection in a time series aims to discover the time points at which some unknown underlying physical process that generates the time-series data has changed. We found that existing approaches become less accurate when the…

Machine Learning · Computer Science 2020-08-04 Varsha Suresh , Wei Tsang Ooi

Glaucoma is a common eye disease that leads to irreversible blindness unless timely detected. Hence, glaucoma detection at an early stage is of utmost importance for a better treatment plan and ultimately saving the vision. The recent…

Computer Vision and Pattern Recognition · Computer Science 2024-09-25 Dipankar Das , Deepak Ranjan Nayak

Glaucoma is a chronic neurodegenerative condition that can lead to blindness. Early detection and curing are very important in stopping the disease from getting worse for glaucoma patients. The 2D fundus images and optical coherence…

Image and Video Processing · Electrical Eng. & Systems 2023-11-15 Wenyun Li , Chi-Man Pun

A central challenge in modeling neurodegenerative diseases is connecting cellular-level mechanisms to tissue-level pathology, in particular to determine whether pathology is driven primarily by cell-autonomous triggers or by propagation…

Quantitative Methods · Quantitative Biology 2026-02-18 Shih-Huan Huang , Matthew W. Cotton , Tuomas P. J. Knowles , David Klenerman , Georg Meisl

We describe a new approach to automated Glaucoma detection in 3D Spectral Domain Optical Coherence Tomography (OCT) optic nerve scans. First, we gathered a unique and diverse multi-ethnic dataset of OCT scans consisting of glaucoma and…

Clinical outcome or severity prediction from medical images has largely focused on learning representations from single-timepoint or snapshot scans. It has been shown that disease progression can be better characterized by temporal imaging.…

Image and Video Processing · Electrical Eng. & Systems 2022-04-01 Aishik Konwer , Xuan Xu , Joseph Bae , Chao Chen , Prateek Prasanna

Statistical models used to estimate the spatio-temporal pattern in disease risk from areal unit data represent the risk surface for each time period with known covariates and a set of spatially smooth random effects. The latter act as a…

Applications · Statistics 2016-04-19 Alastair Rushworth , Duncan Lee , Christophe Sarran

Glaucoma causes an irreversible damage to retinal nerve fibers which results in vision loss, if undetected in early stage. Therefore, diagnosis of glaucoma in its early stage may prevent further vision loss. In this paper, we propose a…

Signal Processing · Electrical Eng. & Systems 2020-09-15 Shishir Maheshwari , Vivek Kanhangad , Ram Bilas Pachori

Detecting what has changed in an environment is essential for long-term autonomy, yet most change detection settings assume fixed viewpoints, mild misalignment, or only a few changed objects. We introduce Video-based Scene Change Detection…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Jiae Yoon , Ue-Hwan Kim

Changepoints are a very common feature of Big Data that arrive in the form of a data stream. In this paper, we study high-dimensional time series in which, at certain time points, the mean structure changes in a sparse subset of the…

Methodology · Statistics 2017-03-21 Tengyao Wang , Richard J. Samworth

Musculoskeletal diseases and cognitive impairments in patients lead to difficulties in movement as well as negative effects on their psychological health. Clinical gait analysis, a vital tool for early diagnosis and treatment, traditionally…

Computer Vision and Pattern Recognition · Computer Science 2024-03-04 Quoc Hung T. Le , Hieu H. Pham

Early and accurate detection of glaucoma is critical to prevent irreversible vision loss. However, existing methods often rely on unimodal data and lack interpretability, limiting their clinical utility. In this paper, we present GlaBoost,…

Machine Learning · Computer Science 2025-08-07 Cheng Huang , Weizheng Xie , Karanjit Kooner , Tsengdar Lee , Jui-Kai Wang , Jia Zhang

An optical flow gradient algorithm was applied to spontaneously forming net- works of neurons and glia in culture imaged by fluorescence optical microscopy in order to map functional calcium signaling with single pixel resolution. Optical…

Computational Engineering, Finance, and Science · Computer Science 2010-01-22 Marius Buibas , Diana Yu , Krystal Nizar , Gabriel A. Silva

Analysis of spatial multivariate data, i.e., measurements at irregularly-spaced locations, is a challenging topic in visualization and statistics alike. Such data are integral to many domains, e.g., indicators of valuable minerals are…

Human-Computer Interaction · Computer Science 2023-08-15 Nikolaus Piccolotto , Markus Bögl , Christoph Muehlmann , Klaus Nordhausen , Peter Filzmoser , Silvia Miksch