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Ultrasound localization microscopy offers new radiation-free diagnostic tools for vascular imaging deep within the tissue. Sequential localization of echoes returned from inert microbubbles with low-concentration within the bloodstream…

Medical Physics · Physics 2018-04-11 Oren Solomon , Ruud J. G. van Sloun , Hessel Wijkstra , Massimo Mischi , Yonina C. Eldar

Super-Resolution Ultrasound (SRUS) imaging through localising and tracking microbubbles, also known as Ultrasound Localisation Microscopy (ULM), has demonstrated significant potential for reconstructing microvasculature and flows with…

Image and Video Processing · Electrical Eng. & Systems 2025-03-26 Jipeng Yan , Qingyuan Tan , Shusei Kawara , Jingwen Zhu , Bingxue Wang , Matthieu Toulemonde , Honghai Liu , Ying Tan , Meng-Xing Tang

Non-invasive detection of microvascular alterations in deep tissues in vivo provides critical information for clinical diagnosis and evaluation of a broad-spectrum of pathologies. Recently, the emergence of super-resolution ultrasound…

Transcranial focused ultrasound (FUS) is a non-invasive technique for therapy and study of brain neural activation. Here we report on the design and characterization of a new MR-guided FUS transducer for neuromodulation in non-human…

Medical Physics · Physics 2018-06-13 Vandiver Chaplin , Marshal A. Phipps , Charles F. Caskey

Ultrasound localization microscopy has enabled super-resolution vascular imaging through precise localization of individual ultrasound contrast agents (microbubbles) across numerous imaging frames. However, analysis of high-density regions…

Signal Processing · Electrical Eng. & Systems 2018-12-14 Ruud J. G. van Sloun , Oren Solomon , Matthew Bruce , Zin Z. Khaing , Hessel Wijkstra , Yonina C. Eldar , Massimo Mischi

Super-resolution ultrasound imaging (SRUS) is an active area of research as it brings up to a ten-fold improvement in the resolution of microvascular structures. The limitations to the clinical adoption of SRUS include long acquisition…

Image and Video Processing · Electrical Eng. & Systems 2024-08-05 Arthur David Redfern , Katherine G. Brown

The correction of the aberration of transcranial focused ultrasounds is a relevant issue for enhancing various non-invasive medical treatments. Emission through multi-element phased arrays has been the most widely accepted method to reduce…

Medical Physics · Physics 2018-05-28 Marcelino Ferri , JM Bravo , Javier Redondo , JV Sánchez-Pérez

Ultrasound super-localization microscopy techniques presented in the last few years enable non-invasive imaging of vascular structures at the capillary level by tracking the flow of ultrasound contrast agents (gas microbubbles). However,…

Tissues and Organs · Quantitative Biology 2016-08-10 Avinoam Bar-Zion , Charles Tremblay-Darveau , Oren Solomon , Dan Adam , Yonina C. Eldar

Ultrasonic superresolution images can be generated by means of (super) focusing acoustic beams to subwavelength dimensions or using algorithm-based methods. Here, we demonstrate that ultrasonic pulses which are superfocused by a ball-shaped…

Applied Physics · Physics 2020-01-14 Victor H. S. Santos , Everton B. Lima , Andre L. Baggio , Jose H. Lopes , Glauber T. Silva

Human skull poses a significant barrier for the propagation of ultrasound waves. Development of methods enabling more efficient ultrasound transmission into and from the brain is therefore critical for the advancement of ultrasound-mediated…

Transcranial ultrasound applications require accurate simulations to predict intracranial acoustic pressure fields. The current gold standard typically consists of calculating a longitudinal ultrasound wave propagation using a fluid skull…

Ultra-high field MRI offers unprecedented detail for non-invasive visualization of the human brain. However, brain imaging is challenging at 7T due to the B$_1^+$ field inhomogeneity, which results in signal intensity drops in temporal…

Medical Physics · Physics 2024-03-13 Vladislav Koloskov , Wyger Brink , Andrew Webb , Alena Shchelokova

This paper presents a generative model for super-resolution in routine clinical magnetic resonance images (MRI), of arbitrary orientation and contrast. The model recasts the recovery of high resolution images as an inverse problem, in which…

Computer Vision and Pattern Recognition · Computer Science 2019-09-10 Mikael Brudfors , Yael Balbastre , Parashkev Nachev , John Ashburner

High-resolution fMRI provides a window into the brain's mesoscale organization. Yet, higher spatial resolution increases scan times, to compensate for the low signal and contrast-to-noise ratio. This work introduces a deep learning-based 3D…

Image and Video Processing · Electrical Eng. & Systems 2024-03-20 Hongwei Bran Li , Matthew S. Rosen , Shahin Nasr , Juan Eugenio Iglesias

Ultrasound Localization Microscopy (ULM) has recently enabled the mapping of the cerebral vasculature in vivo with a resolution ten times smaller than the wavelength used, down to ten microns. However, with frame rates up to 20.000 frames…

Medical Physics · Physics 2023-10-23 Erwan Hardy , Jonathan Poree , Hatim Belgharbi , Chloe Bourquin , Frederic Lesage , Jean Provost

Super-resolution ultrasound imaging through microbubble (MB) localisation and tracking, also known as ultrasound localisation microscopy, allows non-invasive sub-diffraction resolution imaging of microvasculature in animals and humans. The…

Image and Video Processing · Electrical Eng. & Systems 2025-05-23 Su Yan , Clotilde Vié , Marcelo Lerendegui , Herman Verinaz-Jadan , Jipeng Yan , Martina Tashkova , James Burn , Bingxue Wang , Gary Frost , Kevin G. Murphy , Meng-Xing Tang

Super-resolving medical images can help physicians in providing more accurate diagnostics. In many situations, computed tomography (CT) or magnetic resonance imaging (MRI) techniques capture several scans (modes) during a single…

The improvement of computed tomography (CT) image resolution is beneficial to the subsequent medical diagnosis, but it is usually limited by the scanning devices and great expense. Convolutional neural network (CNN)-based methods have…

Medical Physics · Physics 2019-03-26 Chao Tang , Wenkun Zhang , Ziheng Li , Ailong Cai , Linyuan Wang , Lei Li , Ningning Liang , Bin Yan

Recently, the Magnetic Resonance Imaging (MRI) images have limited and unsatisfactory resolutions due to various constraints such as physical, technological and economic considerations. Super-resolution techniques can obtain high-resolution…

Computer Vision and Pattern Recognition · Computer Science 2019-02-14 Yinghua Li , Bin Song , Jie Guo , Xiaojiang Du , Mohsen Guizani

Super-resolution ultrasound can image microvascular structure and flow at sub-wave-diffraction resolution based on localising and tracking microbubbles. Currently, tracking microbubbles accurately under limited imaging frame rates and high…

Image and Video Processing · Electrical Eng. & Systems 2023-04-04 Biao Huang , Jipeng Yan , Megan Morris , Victoria Sinnett , Navita Somaiah , Meng-Xing Tang