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The microvascular networks in the body of vertebrates consist of the smallest vessels such as arterioles, capillaries, and venules. The flow of RBCs through these networks ensures the gas exchange in as well as the transport of nutrients to…

Biological Physics · Physics 2021-02-26 A. Kihm , S. Quint , M. W. Laschke , M. D. Menger , T. John , L. Kaestner , C. Wagner

One-dimensional blood flow models take the general form of nonlinear hyperbolic systems but differ greatly in their formulation. One class of models considers the physically conserved quantities of mass and momentum, while another class…

Fluid Dynamics · Physics 2016-04-19 Charles Puelz , Suncica Canic , Beatrice Riviere , Craig G. Rusin

This study introduces an open-source computational framework for the generation and permeability evaluation of synthetic porous media. The proposed methodology integrates crystallographic and meshing tools to construct controlled…

Tissues and Organs · Quantitative Biology 2025-02-21 Thomas Lavigne , Camilo Andrés Suarez Afanador , Anas Obeidat , Stéphane Urcun

Modelling the sudden depressurisation of superheated liquids through nozzles is a challenge because the pressure drop causes rapid flash boiling of the liquid. The resulting jet usually demonstrates a wide range of structures, including…

Fluid Dynamics · Physics 2021-12-15 David Schmidt , Romit Maulik , Konstantinos G. Lyras

Systems comprising a turbulent channel flow overlaying a permeable bed can be found in a variety of industrial and natural applications (e.g. urban planning, fracking, submerged vegetation). One important realization of this system is at…

Fluid Dynamics · Physics 2017-08-01 Benjamin H. Sonin

A new two-dimensional model for blood flows in arteries with arbitrary cross sections is derived. The model consists of a system of balance laws for conservation of mass and balance of momentum in the axial and angular directions. The…

Numerical Analysis · Mathematics 2021-08-23 Cesar Alberto Rosales-Alcantar , Gerardo Hernandez-Duenas

In this paper, we extend the Darcy law for micropolar fluid flow in a thin porous medium. This provides a framework for understanding how a fluid's microstructural properties, the geometry of the porous medium and the thickness of the…

Analysis of PDEs · Mathematics 2025-08-07 María Anguiano , Francisco J. Suárez-Grau

We propose simple methods for multivariate diffusion bridge simulation, which plays a fundamental role in simulation-based likelihood and Bayesian inference for stochastic differential equations. By a novel application of classical coupling…

Statistics Theory · Mathematics 2014-06-02 Mogens Bladt , Samuel Finch , Michael Sørensen

The blood vascular system consists of blood vessels such as arteries, arterioles, capillaries and veins that convey blood throughout the body. The pressure difference which exists between the ends of the vessels provides the living force…

Tissues and Organs · Quantitative Biology 2020-04-21 Tahmineh Azizi , Robert Mugabi

We investigate the margination of microparticles/platelets in blood flow through complex geometries typical for in vivo vessel networks: a vessel confluence and a bifurcation. Using 3D Lattice-Boltzmann simulations, we confirm that behind…

Biological Physics · Physics 2018-08-15 C. Bächer , A. Kihm , L. Schrack , L. Kaestner , M. W. Laschke , C. Wagner , S. Gekle

Two-scale models pose a promising approach in simulating reactive flow and transport in evolving porous media. Classically, homogenized flow and transport equations are solved on the macroscopic scale, while effective parameters are…

Analysis of PDEs · Mathematics 2022-02-01 Stephan Gärttner , Peter Knabner , Nadja Ray

Developing an organoid computing platform from neurons in vitro demands stable, precisely controlled microenvironments. To address this requirement, we designed, simulated, and fabricated a microfluidic device featuring hexagonal wells…

Fluid Dynamics · Physics 2025-08-04 Maxx Yung

Homogenization method is used to analyse the equivalent behavior of transient flow of a passive solute through highly heterogeneous porous media. The flow is governed by a coupled system which includes an elliptic equation and a linear…

Mathematical Physics · Physics 2007-05-23 Brahim Amaziane , Alain Bourgeat , Mladen Jurak

Molecular dynamics simulation is applied to Poiseuille flow of liquid methane in planar graphite channels, covering channel diameters between 3 and 135 nm. On this length scale, a transition is found between the regime where local ordering…

In the last years, medical computer simulation has seen a great growth in several scientific branches, from modelling to numerical methods, going through computer science. The main goals of this incipient discipline are testing hypotheses…

Fluid Dynamics · Physics 2017-10-20 Cristóbal Rodero Gómez

Mathematical modelling of coupled flow systems containing a free-flow region in contact with a porous medium is challenging, especially for arbitrary flow directions to the fluid--porous interface. Transport processes in the free flow and…

Fluid Dynamics · Physics 2025-02-04 Linheng Ruan , Iryna Rybak

In this paper, a novel deep learning framework is proposed for temporal super-resolution simulation of blood vessel flows, in which a high-temporal-resolution time-varying blood vessel flow simulation is generated from a…

Image and Video Processing · Electrical Eng. & Systems 2021-11-23 Zhizheng Jiang , Fei Gao , Renshu Gu , Jinlan Xu , Gang Xu , Timon Rabczuk

Muscle contraction, both in skeletal and cardiac tissue, is driven by sarcomeres, the microscopic units inside muscle cells where thick myosin and thin actin filaments slide past each other. During contraction and relaxation, the…

Fluid Dynamics · Physics 2025-03-19 John Severn , Thomas Vacus , Eric Lauga

Predicting the flow of non-Newtonian fluids in porous structure is still a challenging issue due to the interplay betwen the microscopic disorder and the non-linear rheology. In this letter, we study the case of an yield stress fluid in a…

Soft Condensed Matter · Physics 2019-06-26 Chen Liu , Andrea De Luca , Alberto Rosso , Laurent Talon

A new slender-body theory for viscous flow, based on the concepts of dimensional reduction and hyperviscous regularization, is presented. The geometry of flat, elongated, or point-like rigid bodies immersed in a viscous fluid is…

Fluid Dynamics · Physics 2016-03-23 Giulio G. Giusteri , Eliot Fried