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Computational models are increasingly used in high-impact decision making in science, engineering, and medicine. The National Aeronautics and Space Administration (NASA) uses computational models to perform complex experiments that are…

Molecular Networks · Quantitative Biology 2023-01-18 Lillian T. Tatka , Lucian P. Smith , Joseph L. Hellerstein , Herbert M. Sauro

The impact of machine learning models on healthcare will depend on the degree of trust that healthcare professionals place in the predictions made by these models. In this paper, we present a method to provide people with clinical expertise…

Machine Learning · Computer Science 2021-03-05 Aniruddh Raghu , John Guttag , Katherine Young , Eugene Pomerantsev , Adrian V. Dalca , Collin M. Stultz

Medical AI agents increasingly use external tools for diagnosis, treatment recommendation, and evidence retrieval, yet most existing approaches assume that task-appropriate tools are reliable within their intended scope. This assumption is…

Artificial Intelligence · Computer Science 2026-05-27 Yunhui Gan , Tan Pan , Kaiyu Guo , Limei Han , Weimiao Yu , Guangnan Ye , Chen Jiang , Yuan Cheng

Advanced medical devices exploit the advantages of embedded software whose development is subject to compliance with stringent requirements of standardization and certification regimes due to the critical nature of such systems. This paper…

Software Engineering · Computer Science 2017-06-21 Atif Mashkoor

Healthcare is one of the largest business segments in the world and is a critical area for future growth. In order to ensure efficient access to medical and patient-related information, hospitals have invested heavily in improving clinical…

Computers and Society · Computer Science 2018-07-06 Andrea Marrella , Massimo Mecella , Mahmoud Sharf , Tiziana Catarci

Risk prediction is central to both clinical medicine and public health. While many machine learning models have been developed to predict mortality, they are rarely applied in the clinical literature, where classification tasks typically…

Machine Learning · Statistics 2017-12-05 Maggie Makar , Marzyeh Ghassemi , David Cutler , Ziad Obermeyer

We present an overview of recently developed data-driven tools for safety analysis of autonomous vehicles and advanced driver assist systems. The core algorithms combine model-based, hybrid system reachability analysis with sensitivity…

Systems and Control · Computer Science 2017-04-24 Chuchu Fan , Bolun Qi , Sayan Mitra

Large language models have achieved strong performance on medical reasoning benchmarks, yet their deployment in clinical settings demands rigorous verification to ensure factual accuracy. While reward models offer a scalable approach for…

Artificial Intelligence · Computer Science 2026-01-29 Hang Zhang , Ruheng Wang , Yuelyu Ji , Mingu Kwak , Xizhi Wu , Chenyu Li , Li Zhang , Wenqi Shi , Yifan Peng , Yanshan Wang

Surgical procedures are often not "standardised" (i.e., defined in a unique and unambiguous way), but rather exist as implicit knowledge in the minds of the surgeon and the surgical team. This reliance extends to pre-surgery planning and…

Cryptography and Security · Computer Science 2024-08-12 Ioana Sandu , Rita Borgo , Prokar Dasgupta , Ramesh Thurairaja , Luca Viganò

Biomedical challenges have become the de facto standard for benchmarking biomedical image analysis algorithms. While the number of challenges is steadily increasing, surprisingly little effort has been invested in ensuring high quality…

Computer Vision and Pattern Recognition · Computer Science 2019-12-06 Manuel Wiesenfarth , Annika Reinke , Bennett A. Landman , Manuel Jorge Cardoso , Lena Maier-Hein , Annette Kopp-Schneider

The proliferation of consumer health devices such as smart watches, sleep monitors, smart scales, etc, in many countries, has not only led to growing interest in health monitoring, but also to the development of a countless number of…

Human-Computer Interaction · Computer Science 2023-08-21 Saturnino Luz , Masood Masoodian

Interpretability methods aim to help users build trust in and understand the capabilities of machine learning models. However, existing approaches often rely on abstract, complex visualizations that poorly map to the task at hand or require…

Human-Computer Interaction · Computer Science 2021-07-12 Harini Suresh , Kathleen M. Lewis , John V. Guttag , Arvind Satyanarayan

There is a growing demand for the use of Artificial Intelligence (AI) and Machine Learning (ML) in healthcare, particularly as clinical decision support systems to assist medical professionals. However, the complexity of many of these…

Human-Computer Interaction · Computer Science 2025-05-13 Dima Alattal , Asal Khoshravan Azar , Puja Myles , Richard Branson , Hatim Abdulhussein , Allan Tucker

Healthcare organizations are in a continuous effort to improve health outcomes, reduce costs and enhance patient experience of care. Data is essential to measure and help achieving these improvements in healthcare delivery. Consequently, a…

Computation and Language · Computer Science 2018-08-13 Steffen Pauws , Albert Gatt , Emiel Krahmer , Ehud Reiter

Effective, reliable, and scalable development of machine learning (ML) solutions for structured electronic health record (EHR) data requires the ability to reliably generate high-quality baseline models for diverse supervised learning tasks…

Incorporating historical data or real-world evidence has a great potential to improve the efficiency of phase I clinical trials and to accelerate drug development. For model-based designs, such as the continuous reassessment method (CRM),…

Methodology · Statistics 2020-06-11 Yanhong Zhou , J. Jack Lee , Shunguang Wang , Stuart Bailey , Ying Yuan

Dynamic treatment regimes have been proposed to personalize treatment decisions by utilizing historical patient data, but they may not always improve on the current standard of care. It is thus meaningful to integrate the standard of care…

Applications · Statistics 2025-12-11 Johannes Hruza , Arvid Sjölander , Erin Gabriel , Samir Bhatt , Michael Sachs

Electronic health records (EHRs), which contain patients' medical histories, tend to be written in freely formatted (unstructured) text because they are complicated by their nature. Quickly understanding a patient's history is challenging…

Human-Computer Interaction · Computer Science 2023-06-27 Shuntaro Yada , Eiji Aramaki

The continued integration of technology into all aspects of society stresses the need to identify and understand the risk associated with assimilating new technologies. This necessity is heightened when technology is used for medical…

Cryptography and Security · Computer Science 2017-09-18 Patrick Luckett , J Todd McDonald , William Bradley Glisson

LLM-based agents have demonstrated strong potential for autonomous machine learning, yet their applicability to health data remains limited. Existing systems often struggle to generalize across heterogeneous health data modalities, rely…

Artificial Intelligence · Computer Science 2026-02-03 Tong Xia , Weibin Li , Gang Liu , Yong Li
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