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As a non-invasive imaging modality, optical coherence tomography (OCT) can provide micrometer-resolution 3D images of retinal structures. Therefore it is commonly used in the diagnosis of retinal diseases associated with edema in and under…

Computer Vision and Pattern Recognition · Computer Science 2017-10-16 Donghuan Lu , Morgan Heisler , Sieun Lee , Gavin Ding , Marinko V. Sarunic , Mirza Faisal Beg

Extensive research works demonstrate that the attention mechanism in convolutional neural networks (CNNs) effectively improves accuracy. Nevertheless, few works design attention mechanisms using large receptive fields. In this work, we…

Computer Vision and Pattern Recognition · Computer Science 2023-06-21 Chun Bao , Jie Cao , Yaqian Ning , Yang Cheng , Qun Hao

For screening, 3D shape of the eye retina often provides structural information and can assist ophthalmologists to diagnose diseases. However, fundus images which are one the most common screening modalities for retina diagnosis lack this…

Image and Video Processing · Electrical Eng. & Systems 2020-12-29 Peyman Tahghighi , Reza A. Zoroofi , Sare Safi , Alireza Ramezani

Optogenetics is a revolutionary new field of biotechnology, achieving optical control over biological functions in living cells by genetically inserting light sensitive proteins into cellular signaling pathways. Applications of optogenetic…

Quantitative Methods · Quantitative Biology 2018-10-29 Zachary Quine , Alexei Goun , Karl Gerhardt , Jeffrey Tabor , Herschel Rabitz

Purpose: To assess whether a generative adversarial network (GAN) could synthesize realistic optical coherence tomography (OCT) images that satisfactorily serve as the educational images for retinal specialists and the training datasets for…

Medical Physics · Physics 2020-06-02 Ce Zheng , Xiaolin Xie , Kang Zhou , Bang Chen , Jili Chen , Haiyun Ye , Wen Li , Tong Qiao , Shenghua Gao , Jianlong Yang , Jiang Liu

Interpretability is crucial to enhance trust in machine learning models for medical diagnostics. However, most state-of-the-art image classifiers based on neural networks are not interpretable. As a result, clinicians often resort to known…

Optical Coherence Tomography (OCT) provides valuable insights in ophthalmology, cardiology, and neurology due to high-resolution, cross-sectional images of the retina. One critical task for ophthalmologists using OCT is delineation of…

Image and Video Processing · Electrical Eng. & Systems 2025-05-21 Samuel T. M. Ball

Today, more than 12 million people over the age of 40 suffer from ocular diseases. Most commonly, older patients are susceptible to age related macular degeneration, an eye disease that causes blurring of the central vision due to the…

Image and Video Processing · Electrical Eng. & Systems 2022-05-03 Ananya Dua , Pham Hung Minh , Sajid Fahmid , Shikhar Gupta , Sophia Zheng , Vanessa Moyo , Yanran Elisa Xue

Inspired by the recent advances in implicitly representing signals with trained neural networks, we aim to learn a continuous representation for narrow-baseline 4D light fields. We propose an implicit representation model for 4D light…

Computer Vision and Pattern Recognition · Computer Science 2021-12-02 Paramanand Chandramouli , Hendrik Sommerhoff , Andreas Kolb

We present a novel approach to neural response prediction that incorporates higher-order operations directly within convolutional neural networks (CNNs). Our model extends traditional 3D CNNs by embedding higher-order operations within the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Simone Azeglio , Victor Calbiague Garcia , Guilhem Glaziou , Peter Neri , Olivier Marre , Ulisse Ferrari

Optical coherence tomography (OCT) is used for non-invasive diagnosis of diabetic macular edema assessing the retinal layers. In this paper, we propose a new fully convolutional deep architecture, termed ReLayNet, for end-to-end…

Computer Vision and Pattern Recognition · Computer Science 2017-07-10 Abhijit Guha Roy , Sailesh Conjeti , Sri Phani Krishna Karri , Debdoot Sheet , Amin Katouzian , Christian Wachinger , Nassir Navab

We study the problem of sparse nonlinear model recovery of high dimensional compositional functions. Our study is motivated by emerging opportunities in neuroscience to recover fine-grained models of biological neural circuits using…

Quantitative Methods · Quantitative Biology 2021-06-11 Dawna Bagherian , James Gornet , Jeremy Bernstein , Yu-Li Ni , Yisong Yue , Markus Meister

Nonlinear optical processing of ambient natural light is highly desired in computational imaging and sensing applications. A strong optical nonlinear response that can work under weak broadband incoherent light is essential for this…

Optical coherence tomography (OCT) is a noninvasive imaging modality which can be used to obtain depth images of the retina. The changing layer thicknesses can thus be quantified by analyzing these OCT images, moreover these changes have…

Computer Vision and Pattern Recognition · Computer Science 2018-03-15 Yufan He , Aaron Carass , Bruno M. Jedynak , Sharon D. Solomon , Shiv Saidha , Peter A. Calabresi , Jerry L. Prince

Noisy data and the similarity in the ocular appearances caused by different ophthalmic pathologies pose significant challenges for an automated expert system to accurately detect retinal diseases. In addition, the lack of knowledge…

Image and Video Processing · Electrical Eng. & Systems 2021-10-20 Sharif Amit Kamran , Alireza Tavakkoli , Stewart Lee Zuckerbrod

To study whether it is possible to differentiate intermediate age-related macular degeneration (AMD) from healthy controls using partial optical coherence tomography (OCT) data, that is, restricting the input B-scans to certain pre-defined…

Image and Video Processing · Electrical Eng. & Systems 2023-07-17 Danilo A. Jesus , Eric F. Thee , Tim Doekemeijer , Daniel Luttikhuizen , Caroline Klaver , Stefan Klein , Theo van Walsum , Hans Vingerling , Luisa Sanchez

Optical Coherence Tomography(OCT) is a non-invasive technique capturing cross-sectional area of the retina in micro-meter resolutions. It has been widely used as a auxiliary imaging reference to detect eye-related pathology and predict…

Image and Video Processing · Electrical Eng. & Systems 2022-09-01 Shuo Chen , Da Ma , Sieun Lee , Timothy T. L. Yu , Gavin Xu , Donghuan Lu , Karteek Popuri , Myeong Jin Ju , Marinko V. Sarunic , Mirza Faisal Beg

Cell crawling on flat substrates is based on intracellular flows of the actin cytoskeleton that are driven by both actin polymerization at the front and myosin contractility at the back. The new experimental tool of optogenetics makes it…

Subcellular Processes · Quantitative Biology 2023-07-04 Oliver M. Drozdowski , Falko Ziebert , Ulrich S. Schwarz

With a kind of magnetism, the human retina draws the eye of neuroscientist and physicist alike. It is attractive as a self-organizing system, which forms as a part of the central nervous system via biochemical and mechanical cues. The…

Tissues and Organs · Quantitative Biology 2022-01-19 Katja A. Salbaum , Elijah R. Shelton , Friedhelm Serwane

Tactile displays that lend tangible form to digital content could transform computing interactions. However, achieving the resolution, speed, and dynamic range needed for perceptual fidelity remains challenging. We present a tactile display…

Emerging Technologies · Computer Science 2026-01-27 Max Linnander , Dustin Goetz , Gregory Reardon , Vijay Kumar , Elliot Hawkes , Yon Visell