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From a systems biology perspective the majority of cancer models, although interesting and providing a qualitative explanation of some problems, have a major disadvantage in that they usually miss a genuine connection with experimental…

Statistics Theory · Mathematics 2023-05-25 Zuzanna Szymańska , Jakub Skrzeczkowski , Błażej Miasojedow , Piotr Gwiazda

Resistance to therapy remains a significant challenge in cancer treatment, often due to the presence of a stem-like cell population that drives tumor recurrence post-treatment. Moreover, many anticancer therapies induce plasticity,…

Populations and Evolution · Quantitative Biology 2024-12-25 Chenyu Wu , Einar Bjarki Gunnarsson , Jasmine Foo , Kevin Leder

Given only data generated by a standard confounding graph with unobserved confounder, the Average Treatment Effect (ATE) is not identifiable. To estimate the ATE, a practitioner must then either (a) collect deconfounded data;(b) run a…

Machine Learning · Statistics 2021-03-09 Kyra Gan , Andrew A. Li , Zachary C. Lipton , Sridhar Tayur

Many spatial phenomena exhibit treatment interference where treatments at one location may affect the response at other locations. Because interference violates the stable unit treatment value assumption, standard methods for causal…

Methodology · Statistics 2020-07-02 Andrew Giffin , Brian Reich , Shu Yang , Ana Rappold

Causal processes in nature may contain cycles, and real datasets may violate causal sufficiency as well as contain selection bias. No constraint-based causal discovery algorithm can currently handle cycles, latent variables and selection…

Machine Learning · Statistics 2018-05-08 Eric V. Strobl

In this paper the concept of Critical Community Size (CCS) for the deterministic SIR model is introduced and its consequences for the disease dynamics are stressed. The disease can fade out after an outburst. Also the principle of…

Populations and Evolution · Quantitative Biology 2020-05-01 Marcilio Ferreira dos Santos , Cesar Castilho

A key question in causal inference analyses is how to find subgroups with elevated treatment effects. This paper takes a machine learning approach and introduces a generative model, Causal Rule Sets (CRS), for interpretable subgroup…

Artificial Intelligence · Computer Science 2021-05-21 Tong Wang , Cynthia Rudin

Synthetic aperture radar automatic target recognition (SAR ATR) methods fall short with limited training data. In this letter, we propose a causal interventional ATR method (CIATR) to formulate the problem of limited SAR data which helps us…

Image and Video Processing · Electrical Eng. & Systems 2023-08-21 Chenwei Wang , Xin Chen , You Qin , Siyi Luo , Yulin Huang , Jifang Pei , Jianyu Yang

In social sciences and economics, causal inference traditionally focuses on assessing the impact of predefined treatments (or interventions) on predefined outcomes, such as the effect of education programs on earnings. Causal discovery, in…

Econometrics · Economics 2024-07-12 Martin Huber

This work studies lung tumor growth prediction from sparse and irregular longitudinal computed tomography (CT) observations with measurement variability. A Bayesian physics-informed neural network is developed by combining Gompertz growth…

Machine Learning · Computer Science 2026-05-14 Lingfei Kong , Haoran Ma

We investigate final outcome properties of an SIR (susceptible $\to$ infective $\to$ recovered) epidemic model defined on a population of large sub-communities in which there is stronger disease transmission within the communities than…

Probability · Mathematics 2024-04-08 Frank Ball , David Sirl , Pieter Trapman

Uncertainty quantification is central to many applications of causal machine learning, yet principled Bayesian inference for causal effects remains challenging. Standard Bayesian approaches typically require specifying a probabilistic model…

Machine Learning · Statistics 2026-03-04 Emil Javurek , Dennis Frauen , Yuxin Wang , Stefan Feuerriegel

Early screening for cancer has proven to improve the survival rate and spare patients from intensive and costly treatments due to late diagnosis. Cancer screening in the healthy population involves an initial risk stratification step to…

With medical tests becoming increasingly available, concerns about over-testing and over-treatment dramatically increase. Hence, it is important to understand the influence of testing on treatment selection in general practice. Most…

Methodology · Statistics 2020-08-11 Yun Li , Irina Bondarenko , Michael R. Elliott , Timothy P. Hofer , Jeremy M. G. Taylor

Causal inference is a fundamental research topic for discovering the cause-effect relationships in many disciplines. However, not all algorithms are equally well-suited for a given dataset. For instance, some approaches may only be able to…

Machine Learning · Computer Science 2024-03-11 Zhipeng Ma , Marco Kemmerling , Daniel Buschmann , Chrismarie Enslin , Daniel Lütticke , Robert H. Schmitt

The attributable fraction among the exposed (\textbf{AF}$_e$), also known as the attributable risk or excess fraction among the exposed, is the proportion of disease cases among the exposed that could be avoided by eliminating the exposure.…

Methodology · Statistics 2024-12-30 Kan Chen , Jing Cheng , M. Elizabeth Halloran , Dylan S. Small

The household secondary attack risk (SAR), often called the secondary attack rate or secondary infection risk, is the probability of infectious contact from an infectious household member A to a given household member B, where we define…

Quantitative Methods · Quantitative Biology 2023-10-24 Yushuf Sharker , Eben Kenah

Many disease models focus on characterizing the underlying transmission mechanism but make simple, possibly naive assumptions about how infections are reported. In this note, we use a simple deterministic Susceptible-Infected-Removed (SIR)…

Populations and Evolution · Quantitative Biology 2019-11-28 Sang Woo Park , Benjamin M. Bolker

The cause of failure in cohort studies that involve competing risks is frequently incompletely observed. To address this, several methods have been proposed for the semiparametric proportional cause-specific hazards model under a missing at…

Methodology · Statistics 2020-02-24 Giorgos Bakoyannis , Ying Zhang , Constantin T. Yiannoutsos

Estimating the average treatment causal effect in clustered data often involves dealing with unmeasured cluster-specific confounding variables. Such variables may be correlated with the measured unit covariates and outcome. When the…

Methodology · Statistics 2018-08-07 Zhulin He