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The migratory dynamics of cells in physiological processes, ranging from wound healing to cancer metastasis, rely on contact-mediated cell-cell interactions. These interactions play a key role in shaping the stochastic trajectories of…

Active particles with their characteristic feature of self-propulsion are regarded as the simplest models for motility in living systems. The accumulation of active particles in low activity regions has led to the general belief that…

Soft Condensed Matter · Physics 2021-05-26 Hidde D. Vuijk , Holger Merlitz , Michael Lang , Abhinav Sharma , Jens-Uwe Sommer

The term active matter describes diverse systems, spanning macroscopic (e.g. shoals of fish and flocks of birds) to microscopic scales (e.g. migrating cells, motile bacteria and gels formed through the interaction of nanoscale molecular…

Soft Condensed Matter · Physics 2010-03-11 Gautam I. Menon

Directed transport of interacting active (self-propelled)Brownian particles is numerically investigated in confined geometries (entropic barriers). The self-propelled velocity can break thermodynamical equilibrium and induce the directed…

Statistical Mechanics · Physics 2015-05-12 Bao-quan Ai , Ya-feng He , Wei-rong Zhong

Many cellular processes require a polarization axis which generally initially emerges as an inhomogeneous distribution of molecular markers in the cell. We present a simple analytical model of a general mechanism of cell polarization taking…

Cell Behavior · Quantitative Biology 2009-10-21 Rhoda J. Hawkins , Olivier Benichou , Matthieu Piel , Raphael Voituriez

Transport of molecular motors along protein filaments in a half-closed geometry is a common feature of biologically relevant processes in cellular protrusions. Using a lattice gas model we study how the interplay between active and…

Biological Physics · Physics 2017-03-30 Isabella R. Graf , Erwin Frey

Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling. Previous theoretical studies have shown that faster moving cells favor…

Cell Behavior · Quantitative Biology 2012-05-09 Koichiro Uriu , Saul Ares , Andrew C. Oates , Luis G. Morelli

The quest on how to collectively self-organize in order to maximize the survival chances of the members of a social group requires finding an optimal compromise between maximizing the well-being of an individual and that of the group. Here…

Soft Condensed Matter · Physics 2021-12-08 Alexandra V. Zampetaki , Benno Liebchen , Alexei V. Ivlev , Hartmut Löwen

We have studied experimentally transport properties in a slowly driven granular system which recently was shown to display self-organized criticality [Frette {\em et al., Nature} {\bf 379}, 49 (1996)]. Tracer particles were added to a pile…

Condensed Matter · Physics 2016-08-15 Kim Christensen , Álvaro Corral , Vidar Frette , Jens Feder , Torstein Jøssang

After summarizing basic features of self-organization such as entropy export, feedbacks and nonlinear dynamics, we discuss several examples in biology. The main part of the paper is devoted to a model of active Brownian motion that allows a…

Statistical Mechanics · Physics 2007-05-23 Werner Ebeling , Frank Schweitzer

Stochasticity is a defining feature of the pairwise forces governing interactions in biological systems-from molecular motors to cell-cell adhesion-yet its consequences on large-scale dynamics remain poorly understood. Here, we show that…

Soft Condensed Matter · Physics 2025-08-27 Henry Alston , Raphael Voituriez , Thibault Bertrand

Understanding systems level behaviour of many interacting agents is challenging in various ways, here we'll focus on the how the interaction between components can lead to hierarchical structures with different types of dynamics, or…

Populations and Evolution · Quantitative Biology 2018-12-26 Henrik Jeldtoft Jensen

How motile bacteria move near a surface is a problem of fundamental biophysical interest and is key to the emergence of several phenomena of biological, ecological and medical relevance, including biofilm formation. Solid boundaries can…

Biological Physics · Physics 2019-09-12 Stanislaw Makarchuk , Vasco C. Braz , Nuno A. M. Araújo , Lena Ciric , Giorgio Volpe

We study the behaviour of interacting self-propelled particles, whose self-propulsion speed decreases with their local density. By combining direct simulations of the microscopic model with an analysis of the hydrodynamic equations obtained…

Statistical Mechanics · Physics 2012-06-25 F. D. C. Farrell , J. Tailleur , D. Marenduzzo , M. C. Marchetti

Microorganisms often encounter strong confinement and complex hydrodynamic flows while navigating their habitats. Combining finite-element methods and stochastic simulations, we study the interplay of active transport and heterogeneous…

Soft Condensed Matter · Physics 2025-11-05 Pallabi Das , Mirko Residori , Axel Voigt , Suvendu Mandal , Christina Kurzthaler

Multicellular organisms comprise a diverse collection of stable tissues built from different cell types. It remains unclear how large numbers of interacting cells can precisely coordinate their gene expression during tissue…

Biological Physics · Physics 2022-10-31 Matthew Smart , Anton Zilman

Collective and directed motility or swarming is an emergent phenomenon displayed by many self-organized assemblies of active biological matter such as clusters of embryonic cells during tissue development, cancerous cells during tumor…

Biological Physics · Physics 2016-04-05 Katherine Copenhagen , Ajay Gopinathan

Synchronization is one of the emerging collective phenomena in interacting particle systems. Its ubiquitous presence in nature, science, and technology has fascinated the scientific community over the decades. Moreover, a great deal of…

Adaptation and Self-Organizing Systems · Physics 2023-12-18 Suvam Pal , Gourab Kumar Sar , Dibakar Ghosh , Arnab Pal

The interaction between nano- or micro-sized particles and cell membranes is of crucial importance in many biological and biomedical applications such as drug and gene delivery to cells and tissues. During their cellular uptake, the…

Recent experimental studies have demonstrated that cellular motion can be directed by topographical gradients, such as those resulting from spatial variations in the features of a micropatterned substrate. This phenomenon, known as…