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Throughout the different phases of a drug development program, randomized trials are used to establish the tolerability, safety, and efficacy of a candidate drug. At each stage one aims to optimize the design of future studies by…

Applications · Statistics 2021-02-08 Sebastian Weber , Andrew Gelman , Daniel Lee , Michael Betancourt , Aki Vehtari , Amy Racine

Representative sampling appears rare in empirical software engineering research. Not all studies need representative samples, but a general lack of representative sampling undermines a scientific field. This article therefore reports a…

Software Engineering · Computer Science 2021-10-22 Sebastian Baltes , Paul Ralph

Bayesian linear mixed-effects models and Bayesian ANOVA are increasingly being used in the cognitive sciences to perform null hypothesis tests, where a null hypothesis that an effect is zero is compared with an alternative hypothesis that…

Methodology · Statistics 2023-08-15 Daniel J. Schad , Bruno Nicenboim , Shravan Vasishth

Standard statistical theory has arguably proved to be unsuitable as a basis for constructing a satisfactory completely general framework for performing statistical inference. For example, frequentist theory has never come close to providing…

Other Statistics · Statistics 2025-04-24 Russell J. Bowater

Realizing the full potential of interconnecting the large amounts of data created in physics experiments, phenomenological models and theory simulations requires robust tools for statistical inference. Here I review a particularly promising…

High Energy Physics - Phenomenology · Physics 2019-03-07 Alexander Rothkopf

We introduce Bayesian optimization, a technique developed for optimizing time-consuming engineering simulations and for fitting machine learning models on large datasets. Bayesian optimization guides the choice of experiments during…

Machine Learning · Statistics 2017-11-22 Peter I. Frazier , Jialei Wang

Bayesian optimization is a sample-efficient method for solving expensive, black-box optimization problems. Stochastic programming concerns optimization under uncertainty where, typically, average performance is the quantity of interest. In…

Machine Learning · Statistics 2025-02-19 Jack M. Buckingham , Ivo Couckuyt , Juergen Branke

Bayes factors for composite hypotheses have difficulty in encoding vague prior knowledge, as improper priors cannot be used and objective priors may be subjectively unreasonable. To address these issues I revisit the posterior Bayes factor,…

Methodology · Statistics 2024-02-29 Frank Dudbridge

We study the stability of posterior predictive inferences to the specification of the likelihood model and perturbations of the data generating process. In modern big data analyses, useful broad structural judgements may be elicited from…

Methodology · Statistics 2024-04-30 Jack Jewson , Jim Q. Smith , Chris Holmes

The two statistical methods, namely the frequentist and the Bayesian methods, are both commonly used for probabilistic inference in many scientific situations. However, it is not straightforward to interpret the result of one approach in…

Data Analysis, Statistics and Probability · Physics 2023-09-01 Alan H. Guth , Mohammad Hossein Namjoo

A Bayesian network is a graphical model that encodes probabilistic relationships among variables of interest. When used in conjunction with statistical techniques, the graphical model has several advantages for data analysis. One, because…

Machine Learning · Computer Science 2022-01-11 David Heckerman

A Bayesian network is a widely used probabilistic graphical model with applications in knowledge discovery and prediction. Learning a Bayesian network (BN) from data can be cast as an optimization problem using the well-known…

Artificial Intelligence · Computer Science 2018-11-14 Zhenyu A. Liao , Charupriya Sharma , James Cussens , Peter van Beek

CONTEXT: There is growing interest in establishing software engineering as an evidence-based discipline. To that end, replication is often used to gain confidence in empirical findings, as opposed to reproduction where the goal is showing…

Software Engineering · Computer Science 2018-02-14 Martin Shepperd

An important aspect of Bayesian model selection is how to deal with huge model spaces, since exhaustive enumeration of all the models entertained is unfeasible and inferences have to be based on the very small proportion of models visited.…

Methodology · Statistics 2011-01-25 Gonzalo Garcia-Donato , Miguel Angel Martinez-Beneito

In almost every scientific field, an experiment involves collecting data and then analysing it. The analysis stage will often consist in trying to extract some physical parameter and estimating its uncertainty; this is known as Parameter…

Data Analysis, Statistics and Probability · Physics 2015-06-12 Louis Lyons

Bayesian quadrature is a probabilistic, model-based approach to numerical integration, the estimation of intractable integrals, or expectations. Although Bayesian quadrature was popularised already in the 1980s, no systematic and…

Machine Learning · Computer Science 2026-02-19 Maren Mahsereci , Toni Karvonen

While gravitational waves have not yet been measured directly, data analysis from detection experiments commonly includes an upper limit statement. Such upper limits may be derived via a frequentist or Bayesian approach; the theoretical…

Data Analysis, Statistics and Probability · Physics 2015-03-19 Christian Röver , Chris Messenger , Reinhard Prix

In the case of informative sampling the sampling scheme explicitly or implicitly depends on the response variable. As a result, the sample distribution of response variable can- not be used for making inference about the population. In this…

Applications · Statistics 2016-11-18 Anna Sikov

It is not always clear how to adjust for control data in causal inference, balancing the goals of reducing bias and variance. We show how, in a setting with repeated experiments, Bayesian hierarchical modeling yields an adaptive procedure…

Methodology · Statistics 2025-01-23 Andrew Gelman , Matthijs Vákár

The last decades saw dramatic progress in brain research. These advances were often buttressed by probing single variables to make circumscribed discoveries, typically through null hypothesis significance testing. New ways for generating…

Neurons and Cognition · Quantitative Biology 2019-03-26 Danilo Bzdok , John Ioannidis