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Biochemical processes in cells are governed by complex networks of many chemical species interacting stochastically in diverse ways and on different time scales. Constructing microscopically accurate models of such networks is often…

Quantitative Methods · Quantitative Biology 2021-06-09 Catalina Rivera , David Hofmann , Ilya Nemenman

When inhibitory neurons constitute about 40% of neurons they could have an important antinociceptive role, as they would easily regulate the level of activity of other neurons. We consider a simple network of cortical spiking neurons with…

Neurons and Cognition · Quantitative Biology 2014-01-28 Fernando Montani , Emilia B. Deleglise , Osvaldo A. Rosso

Several experimental studies show the existence of leader neurons in population bursts of 2D living neural networks. A leader neuron is, basically, a neuron which fires at the beginning of a burst (respectively network spike) more often…

Biological Physics · Physics 2010-04-19 Cyrille Zbinden

We propose a unifying theoretical framework for the analysis of first-passage time distributions in two important classes of stochastic processes in which the diffusivity of a particle evolves randomly in time. In the first class of…

Statistical Mechanics · Physics 2019-11-05 D. S. Grebenkov

In this paper we study the iterated birth process of which we examine the first-passage time distributions and the hitting probabilities. Furthermore, linear birth processes, linear and sublinear death processes at Poisson times are…

Probability · Mathematics 2016-03-23 L. Beghin , E. Orsingher

The first-passage time (FPT) of a stochastic signal to a threshold is a fundamental observable across physics, biology, and finance. While renewal shot noise is a canonical model for such signals, analytical results for its FPT have…

Statistical Mechanics · Physics 2026-02-24 Julien Brémont

We provide rigorous and exact results characterizing the statistics of spike trains in a network of leaky integrate and fire neurons, where time is discrete and where neurons are submitted to noise, without restriction on the synaptic…

Dynamical Systems · Mathematics 2011-05-18 B. Cessac

When stimulated by a very large number of Poisson-like presynaptic current input spikes, the temporal dynamics of the soma membrane potential $V(t)$ of a leaky integrate-and-fire (LIF) neuron is typically modeled in the diffusion limit and…

Neurons and Cognition · Quantitative Biology 2015-01-19 Ken Kreutz-Delgado

We briefly review and highlight the consequences of rigorous and exact results obtained in \cite{cessac:10}, characterizing the statistics of spike trains in a network of leaky Integrate-and-Fire neurons, where time is discrete and where…

Adaptation and Self-Organizing Systems · Physics 2010-08-31 Bruno Cessac , Hassan Nasser , Juan-Carlos Vasquez

In recurrent networks of leaky integrate-and-fire (LIF) neurons, mean-field theory has proven successful in describing various statistical properties of neuronal activity at equilibrium, such as firing rate distributions. Mean-field theory…

Neurons and Cognition · Quantitative Biology 2023-11-10 Marina Vegué , Antoine Allard , Patrick Desrosiers

In the absence of inhibition, excitatory neuronal networks can alternate between bursts and interburst intervals (IBI), with heterogeneous length distributions. As this dynamic remains unclear, especially the durations of each epoch, we…

Neurons and Cognition · Quantitative Biology 2020-12-17 Lou Zonca , David Holcman

Noise in spiking neurons is commonly modeled by a noisy input current or by generating output spikes stochastically with a voltage-dependent hazard rate ("escape noise"). While input noise lends itself to modeling biophysical noise…

Neurons and Cognition · Quantitative Biology 2021-09-16 Tilo Schwalger

The response of a neural cell to an external stimulus can follow one of the two patterns: Nonresonant neurons monotonously relax to the resting state after excitation while resonant ones show subthreshold oscillations. We investigate how do…

Neurons and Cognition · Quantitative Biology 2009-11-10 T. Verechtchaguina , L. Schimansky-Geier , I. M. Sokolov

This paper proposes a model of interactions between two point processes, ruled by a reproduction function h, which is considered as the intensity of a Poisson process. In particular, we focus on the context of neurosciences to detect…

Statistics Theory · Mathematics 2014-03-07 Laure Sansonnet , Christine Tuleau-Malot

The mutual information between stimulus and spike-train response is commonly used to monitor neural coding efficiency, but neuronal computation broadly conceived requires more refined and targeted information measures of input-output joint…

Neurons and Cognition · Quantitative Biology 2015-04-21 Sarah E. Marzen , Michael R. DeWeese , James P. Crutchfield

Idealized networks of integrate-and-fire neurons with impulse-like interactions obey McKean-Vlasov diffusion equations in the mean-field limit. These equations are prone to blowups: for a strong enough interaction coupling, the mean-field…

Probability · Mathematics 2022-05-17 Thibaud Taillefumier , Phillip Whitman

The activity of neurons within brain circuits has been ubiquitously reported to be correlated. The impact of these correlations on brain function has been extensively investigated. Correlations can in principle increase or decrease the…

Neurons and Cognition · Quantitative Biology 2025-07-24 Miguel Ibáñez-Berganza , Giulio Bondanelli , Stefano Panzeri

Neurons encode and transmit information in spike sequences. However, despite the effort devoted to quantify their information content, little progress has been made in this regard. Here we use a nonlinear method of time-series analysis…

Neurons and Cognition · Quantitative Biology 2020-02-19 Cristian Estarellas , Maria Masoliver , Cristina Masoller , Claudio Mirasso

We present a mathematical model for communication subject to both network interference and noise. We introduce a framework where the interferers are scattered according to a spatial Poisson process, and are operating asynchronously in a…

Information Theory · Computer Science 2016-11-17 Pedro C. Pinto , Moe Z. Win

Numerical calculations have been made on the spike-train response of a pair of Hodgkin-Huxley (HH) neurons coupled by synapses and axons with time delay. The recurrent excitatory-excitatory, inhibitory-inhibitory, excitatory-inhibitory, and…

Disordered Systems and Neural Networks · Physics 2007-05-23 Hideo Hasegawa