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Persistent homology is a powerful tool for characterizing the topology of a data set at various geometric scales. When applied to the description of molecular structures, persistent homology can capture the multiscale geometric features and…

Quantitative Methods · Quantitative Biology 2018-07-31 Zixuan Cang , Guo-Wei Wei

Persistent Homology (PH) has been successfully used to train networks to detect curvilinear structures and to improve the topological quality of their results. However, existing methods are very global and ignore the location of topological…

Computer Vision and Pattern Recognition · Computer Science 2022-12-27 Doruk Oner , Adélie Garin , Mateusz Koziński , Kathryn Hess , Pascal Fua

Persistent homology (PH) is one of the most popular methods in Topological Data Analysis. Even though PH has been used in many different types of applications, the reasons behind its success remain elusive; in particular, it is not known…

Algebraic Topology · Mathematics 2023-01-18 Renata Turkeš , Guido Montúfar , Nina Otter

We propose a unified framework based on persistent homology (PH) to characterize both local and global structures in disordered systems. It can simultaneously generate local and global descriptors using the same algorithm and data…

Disordered Systems and Neural Networks · Physics 2025-11-03 An Wang , Li Zou

In this paper, we systematically review weighted persistent homology (WPH) models and their applications in biomolecular data analysis. Essentially, the weight value, which reflects physical, chemical and biological properties, can be…

Biomolecules · Quantitative Biology 2019-03-08 Zhenyu Meng , D Vijay Anand , Yunpeng Lu , Jie Wu , Kelin Xia

In this study, we present a novel computational method for generating molecular fingerprints using multiparameter persistent homology (MPPH). This technique holds considerable significance for drug discovery and materials science, where…

Machine Learning · Computer Science 2023-12-14 Andac Demir , Francis Prael , Bulent Kiziltan

Persistent homology is a multiscale method for analyzing the shape of sets and functions from point cloud data arising from an unknown distribution supported on those sets. When the size of the sample is large, direct computation of the…

Multiparameter persistence module can capture more topological differences across data instances compared to using a single parameter, where the well-studied matching distance investigates the distance along a straight line in the…

Algebraic Topology · Mathematics 2025-08-01 Xudong Sun , René Corbet , Carsten Marr

Recent studies have actively employed persistent homology (PH), a topological data analysis technique, to analyze the topological information in time series data. Many successful studies have utilized graph representations of time series…

Algebraic Topology · Mathematics 2025-12-15 Eunwoo Heo , Jae-Hun Jung

Persistent homology is a popular tool in Topological Data Analysis. It provides numerical characteristics of data sets which reflect global geometric properties. In order to be useful in practice, for example for feature generation in…

Computational Geometry · Computer Science 2020-02-17 Boris Goldfarb

The Extended Persistent Homology Transform (XPHT) is a topological transform which takes as input a shape embedded in Euclidean space, and to each unit vector assigns the extended persistence module of the height function over that shape…

Algebraic Topology · Mathematics 2022-09-01 Katharine Turner , Vanessa Robins , James Morgan

Topological data analysis can extract effective information from higher-dimensional data. Its mathematical basis is persistent homology. The persistent homology can calculate topological features at different spatiotemporal scales of the…

Algebraic Topology · Mathematics 2023-09-29 Dinghua Shi , Zhifeng Chen , Chuang Ma , Guanrong Chen

In this study, we present a novel molecular fingerprint generation method based on multiparameter persistent homology. This approach reveals the latent structures and relationships within molecular geometry, and detects topological features…

Biomolecules · Quantitative Biology 2023-11-21 Andac Demir , Bulent Kiziltan

Accurate delineation of fine-scale structures is a very important yet challenging problem. Existing methods use topological information as an additional training loss, but are ultimately making pixel-wise predictions. In this paper, we…

Image and Video Processing · Electrical Eng. & Systems 2022-10-04 Xiaoling Hu , Dimitris Samaras , Chao Chen

We explore the recently introduced persistent reachability homology (PRH) of digraph data, i.e. data in the form of directed graphs. In particular, we study the effectiveness of PRH in network classification task in a key neuroscience…

Machine Learning · Computer Science 2025-11-10 Luigi Caputi , Nicholas Meadows , Henri Riihimäki

We introduce a theoretical and computational framework to use discrete Morse theory as an efficient preprocessing in order to compute zigzag persistent homology. From a zigzag filtration of complexes $(K_i)$, we introduce a zigzag Morse…

Computational Geometry · Computer Science 2019-07-12 Clément Maria , Hannah Schreiber

Computing homology and cohomology is at the heart of many recent works and a key issue for topological data analysis. Among homological objects, homology generators are useful to locate or understand holes (especially for geometric…

Algebraic Topology · Mathematics 2025-12-22 Yann-Situ Gazull , Aldo Gonzalez-Lorenzo , Alexandra Bac

We address the basic question in discrete Morse theory of combining discrete gradient fields that are partially defined on subsets of the given complex. This is a well-posed question when the discrete gradient field $V$ is generated using a…

Geometric Topology · Mathematics 2022-01-28 Douglas Lenseth , Boris Goldfarb

Persistent homology is a popular and powerful tool for capturing topological features of data. Advances in algorithms for computing persistent homology have reduced the computation time drastically -- as long as the algorithm does not…

Computational Geometry · Computer Science 2013-10-03 Ulrich Bauer , Michael Kerber , Jan Reininghaus

We introduce the notion of a template for discrete Morse theory. Templates provide a memory efficient approach to the computation of homological invariants (e.g., homology, persistent homology, Conley complexes) of cell complexes. We…

Algebraic Topology · Mathematics 2021-06-30 Shaun Harker , Konstantin Mischaikow , Kelly Spendlove