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Neural codes are binary codes in $\{0,1\}^n$; here we focus on the ones which represent the firing patterns of a type of neurons called place cells. There is much interest in determining which neural codes can be realized by a collection of…

Neurons and Cognition · Quantitative Biology 2018-07-09 Molly Hoch , Samuel Muthiah , Nida Obatake

A combinatorial neural code $\mathscr C\subseteq 2^{[n]}$ is convex if it arises as the intersection pattern of convex open subsets of $\mathbb R^d$. We relate the emerging theory of convex neural codes to the established theory of oriented…

Combinatorics · Mathematics 2026-03-12 Alexander Kunin , Caitlin Lienkaemper , Zvi Rosen

A neural code $\mathcal{C}$ is a collection of binary vectors of a given length n that record the co-firing patterns of a set of neurons. Our focus is on neural codes arising from place cells, neurons that respond to geographic stimulus. In…

Neurons and Cognition · Quantitative Biology 2016-07-05 Elizabeth Gross , Nida Kazi Obatake , Nora Youngs

Neural codes serve as a language for neurons in the brain. Convex codes, which arise from the pattern of intersections of convex sets in Euclidean space, are of particular relevance to neuroscience. Not every code is convex, however, and…

Combinatorics · Mathematics 2017-05-31 Joshua Cruz , Chad Giusti , Vladimir Itskov , Bill Kronholm

Neural codes allow the brain to represent, process, and store information about the world. Combinatorial codes, comprised of binary patterns of neural activity, encode information via the collective behavior of populations of neurons. A…

Neurons and Cognition · Quantitative Biology 2016-12-22 Carina Curto , Elizabeth Gross , Jack Jeffries , Katherine Morrison , Mohamed Omar , Zvi Rosen , Anne Shiu , Nora Youngs

The brain encodes spacial structure through a combinatorial code of neural activity. Experiments suggest such codes correspond to convex areas of the subject's environment. We present an intrinsic condition that implies a neural code may…

Combinatorics · Mathematics 2016-10-20 Robert Williams

A convex code is a binary code generated by the pattern of intersections of a collection of open convex sets in some Euclidean space. Convex codes are relevant to neuroscience as they arise from the activity of neurons that have convex…

Neurons and Cognition · Quantitative Biology 2018-07-10 Carina Curto , Elizabeth Gross , Jack Jeffries , Katherine Morrison , Zvi Rosen , Anne Shiu , Nora Youngs

Neural codes, represented as collections of binary strings called codewords, are used to encode neural activity. A code is called convex if its codewords are represented as an arrangement of convex open sets in Euclidean space. Previous…

Combinatorics · Mathematics 2022-08-10 Katherine Johnston , Anne Shiu , Clare Spinner

Convex neural codes are subsets of the Boolean lattice that record the intersection patterns of convex sets in Euclidean space. Much work in recent years has focused on finding combinatorial criteria on codes that can be used to classify…

Combinatorics · Mathematics 2020-12-18 R. Amzi Jeffs , Caitlin Lienkaemper , Nora Youngs

We introduce new geometric and combinatorial criteria that preclude a neural code from being convex, and use them to tackle the classification problem for codes on six neurons. Along the way, we give the first example of a code that is…

Combinatorics · Mathematics 2023-02-16 Laura Matusevich , Alexander Ruys de Perez , Anne Shiu

Hyperplane codes are a class of convex codes that arise as the output of a one layer feed-forward neural network. Here we establish several natural properties of stable hyperplane codes in terms of the {\it polar complex} of the code, a…

Neurons and Cognition · Quantitative Biology 2019-02-05 Vladimir Itskov , Alex Kunin , Zvi Rosen

This dissertation explores applications of discrete geometry in mathematical neuroscience. We begin with convex neural codes, which model the activity of hippocampal place cells and other neurons with convex receptive fields. In Chapter 4,…

Neurons and Cognition · Quantitative Biology 2022-09-19 Caitlin Lienkaemper

Determining how the brain stores information is one of the most pressing problems in neuroscience. In many instances, the collection of stimuli for a given neuron can be modeled by a convex set in $\mathbb{R}^d$. Combinatorial objects known…

Combinatorics · Mathematics 2019-05-29 R. Amzi Jeffs , Mohamed Omar , Natchanon Suaysom , Aleina Wachtel , Nora Youngs

Combinatorial neural codes are $0/1$ vectors that are used to model the co-firing patterns of a set of place cells in the brain. One wide-open problem in this area is to determine when a given code can be algorithmically drawn in the plane…

Combinatorics · Mathematics 2018-08-29 Robert Davis

Neural codes are collections of binary strings motivated by patterns of neural activity. In this paper, we study algorithmic and enumerative aspects of convex neural codes in dimension 1 (i.e. on a line or a circle). We use the theory of…

Combinatorics · Mathematics 2017-02-23 Zvi Rosen , Yan X. Zhang

A combinatorial neural code is a subset of the power set $2^{[n]}$ on $[n]=\{1,\dots, n\}$, in which each $1\leq i\leq n$ represents a neuron and each element (codeword) represents the co-firing event of some neurons. Consider a space…

Combinatorics · Mathematics 2025-12-05 R. Amzi Jeffs , Trong-Thuc Trang

Neural codes, represented as collections of binary strings, encode neural activity and show relationships among stimuli. Certain neurons, called place cells, have been shown experimentally to fire in convex regions in space. A natural…

Neurons and Cognition · Quantitative Biology 2019-09-20 Sarah Ayman Goldrup , Kaitlyn Phillipson

Neural ideals were introduced by Curto, Itskov, et al as an algebraic tool to study neural codes. In this paper, we use the notion of polarization introduced by G\"{u}nt\"{u}rk\"{u}n, Jeffries, and Sun to compute Betti numbers of…

Commutative Algebra · Mathematics 2026-05-26 Hugh Geller , Rebecca R. G. , Alexandra Seceleanu , Nora Youngs

Previous work on convexity of neural codes has produced codes that are open-convex but not closed-convex -- or vice-versa. However, why a code is one but not the other, and how to detect such discrepancies are open questions. We tackle…

Combinatorics · Mathematics 2022-08-30 Patrick Chan , Katherine Johnston , Joseph Lent , Alexander Ruys de Perez , Anne Shiu

In the 1970s, O'Keefe and Dostrovsky discovered that certain neurons, called place cells, in an animal's brain are tied to its location within its arena. A combinatorial neural code is a collection of $0/1$-vectors which encode the patterns…

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