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The backpropagation algorithm is often debated for its biological plausibility. However, various learning methods for neural architecture have been proposed in search of more biologically plausible learning. Most of them have tried to solve…

Neural and Evolutionary Computing · Computer Science 2020-11-25 Shashi Kant Gupta

Backpropagation (BP) is the standard algorithm for training the deep neural networks that power modern artificial intelligence including large language models. However, BP is energy inefficient and unlikely to be implemented by the brain.…

Machine Learning · Computer Science 2025-10-30 Francesco Innocenti

Predictive coding networks (PCNs) are an influential model for information processing in the brain. They have appealing theoretical interpretations and offer a single mechanism that accounts for diverse perceptual phenomena of the brain. On…

Machine Learning · Computer Science 2021-03-08 Tommaso Salvatori , Yuhang Song , Thomas Lukasiewicz , Rafal Bogacz , Zhenghua Xu

Training deep neural networks with the error backpropagation algorithm is considered implausible from a biological perspective. Numerous recent publications suggest elaborate models for biologically plausible variants of deep learning,…

Neural and Evolutionary Computing · Computer Science 2019-07-16 Bernd Illing , Wulfram Gerstner , Johanni Brea

One major criticism of deep learning centers around the biological implausibility of the credit assignment schema used for learning -- backpropagation of errors. This implausibility translates into practical limitations, spanning scientific…

Neural and Evolutionary Computing · Computer Science 2024-03-29 Alexander Ororbia , Ankur Mali , Adam Kohan , Beren Millidge , Tommaso Salvatori

In artificial neural networks trained with gradient descent, the weights used for processing stimuli are also used during backward passes to calculate gradients. For the real brain to approximate gradients, gradient information would have…

Neurons and Cognition · Quantitative Biology 2020-02-04 Jordan Guerguiev , Konrad P. Kording , Blake A. Richards

Backpropagation is the foundational algorithm for training neural networks and a key driver of deep learning's success. However, its biological plausibility has been challenged due to three primary limitations: weight symmetry, reliance on…

Neural and Evolutionary Computing · Computer Science 2025-06-05 Changze Lv , Jingwen Xu , Yiyang Lu , Xiaohua Wang , Zhenghua Wang , Zhibo Xu , Di Yu , Xin Du , Xiaoqing Zheng , Xuanjing Huang

Traditional backpropagation of error, though a highly successful algorithm for learning in artificial neural network models, includes features which are biologically implausible for learning in real neural circuits. An alternative called…

Machine Learning · Computer Science 2020-11-06 Nasir Ahmad , Marcel A. J. van Gerven , Luca Ambrogioni

Backpropagation (BP), the standard learning algorithm for artificial neural networks, is often considered biologically implausible. In contrast, the standard learning algorithm for predictive coding (PC) models in neuroscience, known as the…

Neural and Evolutionary Computing · Computer Science 2023-05-24 Nick Alonso , Jeff Krichmar , Emre Neftci

Artificial neural networks, one of the most successful approaches to supervised learning, were originally inspired by their biological counterparts. However, the most successful learning algorithm for artificial neural networks,…

Machine Learning · Computer Science 2020-06-18 Matilde Tristany Farinha , Sérgio Pequito , Pedro A. Santos , Mário A. T. Figueiredo

The paper proposes a new algorithm called SymBa that aims to achieve more biologically plausible learning than Back-Propagation (BP). The algorithm is based on the Forward-Forward (FF) algorithm, which is a BP-free method for training…

Computer Vision and Pattern Recognition · Computer Science 2023-03-16 Heung-Chang Lee , Jeonggeun Song

Spiking neural networks (SNN) are delivering energy-efficient, massively parallel, and low-latency solutions to AI problems, facilitated by the emerging neuromorphic chips. To harness these computational benefits, SNN need to be trained by…

Neural and Evolutionary Computing · Computer Science 2021-10-28 Guangzhi Tang , Neelesh Kumar , Ioannis Polykretis , Konstantinos P. Michmizos

Bio-inspired learning has been gaining popularity recently given that Backpropagation (BP) is not considered biologically plausible. Many algorithms have been proposed in the literature which are all more biologically plausible than BP.…

Machine Learning · Computer Science 2023-08-31 Manas Gupta , Sarthak Ketanbhai Modi , Hang Zhang , Joon Hei Lee , Joo Hwee Lim

Interest in biologically inspired alternatives to backpropagation is driven by the desire to both advance connections between deep learning and neuroscience and address backpropagation's shortcomings on tasks such as online, continual…

Neural and Evolutionary Computing · Computer Science 2020-06-18 Jack Lindsey , Ashok Litwin-Kumar

The state-of-the art machine learning approach to training deep neural networks, backpropagation, is implausible for real neural networks: neurons need to know their outgoing weights; training alternates between a bottom-up forward pass…

Machine Learning · Computer Science 2020-10-26 Roman Pogodin , Peter E. Latham

Backpropagation (BP) of errors is the backbone training algorithm for artificial neural networks (ANNs). It updates network weights through gradient descent to minimize a loss function representing the mismatch between predictions and…

Machine Learning · Statistics 2025-08-13 Davide Casnici , Charlotte Frenkel , Justin Dauwels

Current algorithms for deep learning probably cannot run in the brain because they rely on weight transport, where forward-path neurons transmit their synaptic weights to a feedback path, in a way that is likely impossible biologically. An…

Machine Learning · Computer Science 2020-01-13 Mohamed Akrout , Collin Wilson , Peter C. Humphreys , Timothy Lillicrap , Douglas Tweed

The neural plausibility of backpropagation has long been disputed, primarily for its use of non-local weight transport $-$ the biologically dubious requirement that one neuron instantaneously measure the synaptic weights of another. Until…

Neurons and Cognition · Quantitative Biology 2020-06-26 Daniel Kunin , Aran Nayebi , Javier Sagastuy-Brena , Surya Ganguli , Jonathan M. Bloom , Daniel L. K. Yamins

Backpropagation (BP) has been a successful optimization technique for deep learning models. However, its limitations, such as backward- and update-locking, and its biological implausibility, hinder the concurrent updating of layers and do…

Machine Learning · Computer Science 2023-12-22 Anzhe Cheng , Zhenkun Wang , Chenzhong Yin , Mingxi Cheng , Heng Ping , Xiongye Xiao , Shahin Nazarian , Paul Bogdan

Over the last four decades, the amazing success of deep learning has been driven by the use of Stochastic Gradient Descent (SGD) as the main optimization technique. The default implementation for the computation of the gradient for SGD is…

Neural and Evolutionary Computing · Computer Science 2024-12-31 Qianli Liao , Liu Ziyin , Yulu Gan , Brian Cheung , Mark Harnett , Tomaso Poggio