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In this work we consider the problem of finding optimal regularization parameters for general-form Tikhonov regularization using training data. We formulate the general-form Tikhonov solution as a spectral filtered solution using the…

Numerical Analysis · Mathematics 2014-07-09 Julianne Chung , Malena I. Español , Tuan Nguyen

Identifiability is a necessary condition for successful parameter estimation of dynamic system models. A major component of identifiability analysis is determining the identifiable parameter combinations, the functional forms for the…

Quantitative Methods · Quantitative Biology 2013-10-07 Marisa C. Eisenberg , Michael A. L. Hayashi

We present a novel parameter identification algorithm for the estimation of parameters in models of cell motility using imaging data of migrating cells. Two alternative formulations of the objective functional that measures the difference…

The aim of this paper is to discuss potential advances in PET kinetic models and direct reconstruction of kinetic parameters. As a prominent example we focus on a typical task in perfusion imaging and derive a system of…

Optimization and Control · Mathematics 2014-11-20 Louise Reips , Martin Burger , Ralf Engbers

Both structured componentwise and structured normwise perturbation analysis of the Tikhonov regularization are presented. The structured matrices under consideration include: Toeplitz, Hankel, Vandermonde, and Cauchy matrices. Structured…

Numerical Analysis · Mathematics 2016-01-12 Huai-An Diao , Yimin Wei , Sanzheng Qiao

Accurate determination of the regularization parameter in inverse problems still represents an analytical challenge, owing mainly to the considerable difficulty to separate the unknown noise from the signal. We present a new approach for…

Numerical Analysis · Mathematics 2019-07-24 Eitan Levin , Alexander Y. Meltzer

The aim of this paper is to tackle part of the program set by Diekmann et al. in their seminal paper Diekmann et al. (2001). We quote "It remains to investigate whether, and in what sense, the nonlinear determin-istic model formulation is…

Probability · Mathematics 2018-04-16 Philippe Carmona

The first chapter concerns monotype population models. We first study general birth and death processes and we give non-explosion and extinction criteria, moment computations and a pathwise representation. We then show how different scales…

Probability · Mathematics 2017-07-06 Vincent Bansaye , Sylvie Méléard

This paper focuses on the identification of dynamical systems with tailor-made model structures, where neural networks are used to approximate uncertain components and domain knowledge is retained, if available. These model structures are…

Machine Learning · Computer Science 2021-10-29 Marco Forgione , Dario Piga

Learning the unknown causal parameters of a linear structural causal model is a fundamental task in causal analysis. The task, known as the problem of identification, asks to estimate the parameters of the model from a combination of…

Artificial Intelligence · Computer Science 2024-07-18 Julian Dörfler , Benito van der Zander , Markus Bläser , Maciej Liskiewicz

We develop a general framework for estimating function-valued parameters under equality or inequality constraints in infinite-dimensional statistical models. Such constrained learning problems are common across many areas of statistics and…

Machine Learning · Statistics 2025-07-22 Razieh Nabi , Nima S. Hejazi , Mark J. van der Laan , David Benkeser

Turing patterns play a fundamental role in morphogenesis and population dynamics, encoding key information about the underlying biological mechanisms. Yet, traditional inverse problems have largely relied on non-biological data such as…

Analysis of PDEs · Mathematics 2025-09-10 Yuhan Li , Hongyu Liu , Catharine W. K. Lo

We consider the problem of estimating the parameters of a supercritical controlled branching process consistently from a single observed trajectory of population size counts. Our goal is to establish which parameters can and cannot be…

Probability · Mathematics 2025-08-19 Peter Braunsteins , Sophie Hautphenne , James Kerlidis

Heterogeneity of many building materials complicates numerical modelling of structural behaviour. The material randomicity can be manifested by different values of material parameters of each material specimen. To capture inherent…

Computational Engineering, Finance, and Science · Computer Science 2026-02-17 Eliška Kočková , Anna Kučerová

The general Markov plus invariable sites (GM+I) model of biological sequence evolution is a two-class model in which an unknown proportion of sites are not allowed to change, while the remainder undergo substitutions according to a Markov…

Populations and Evolution · Quantitative Biology 2011-11-10 Elizabeth S. Allman , John A. Rhodes

Mathematical models are routinely applied to interpret biological data, with common goals that include both prediction and parameter estimation. A challenge in mathematical biology, in particular, is that models are often complex and…

Methodology · Statistics 2025-11-18 Alexander P Browning , Jennifer A Flegg , Ryan J Murphy

Parameter estimation is one of the most important tasks in statistics, and is key to helping people understand the distribution behind a sample of observations. Traditionally parameter estimation is done either by closed-form solutions…

Machine Learning · Computer Science 2024-03-04 Xiaoxin Yin , David S. Yin

We consider the problem of estimating the division rate of a size-structured population in a nonparametric setting. The size of the system evolves according to a transport-fragmentation equation: each individual grows with a given transport…

Statistics Theory · Mathematics 2013-01-21 Marie Doumic Jauffret , Marc Hoffmann , Patricia Reynaud-Bouret , Vincent Rivoirard

We propose a modern method to estimate population size based on capture-recapture designs of K samples. The observed data is formulated as a sample of n i.i.d. K-dimensional vectors of binary indicators, where the k-th component of each…

We consider the identification of scattering and absorption rates in the stationary radiative transfer equation. For a stable solution of this parameter identification problem, we consider Tikhonov regularization within Banach spaces. A…

Optimization and Control · Mathematics 2013-11-04 Herbert Egger , Matthias Schlottbom