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We consider the problem of non-parametric regression with a potentially large number of covariates. We propose a convex, penalized estimation framework that is particularly well-suited for high-dimensional sparse additive models. The…

Methodology · Statistics 2019-06-19 Asad Haris , Ali Shojaie , Noah Simon

In this manuscript, we study quantile regression in partial functional linear model where response is scalar and predictors include both scalars and multiple functions. Wavelet basis are adopted to better approximate functional slopes while…

Statistics Theory · Mathematics 2017-12-05 Dengdeng Yu , Li Zhang , Ivan Mizera , Bei Jiang , Linglong Kong

Radiogenomics is an emerging field in cancer research that combines medical imaging data with genomic data to predict patients clinical outcomes. In this paper, we propose a multivariate sparse group lasso joint model to integrate imaging…

Methodology · Statistics 2022-06-06 Tiantian Zeng , Md Selim , Jie Zhang , Arnold Stromberg , Jin Chen , Chi Wang

In regression problems where covariates can be naturally grouped, the group Lasso is an attractive method for variable selection since it respects the grouping structure in the data. We study the selection and estimation properties of the…

Statistics Theory · Mathematics 2010-11-30 Fengrong Wei , Jian Huang

Nowadays, clinical research routinely uses omics data, such as gene expression, for predicting clinical outcomes or selecting markers. Additionally, so-called co-data are often available, providing complementary information on the…

Methodology · Statistics 2021-01-12 Mirrelijn M. van Nee , Tim van de Brug , Mark A. van de Wiel

Feature selection, identifying a subset of variables that are relevant for predicting a response, is an important and challenging component of many methods in statistics and machine learning. Feature selection is especially difficult and…

Quantitative Methods · Quantitative Biology 2014-08-01 Charles K. Fisher , Pankaj Mehta

In 2023, the U.S. Food and Drug Administration issued guidance for adjustment of covariates in randomized clinical trials, emphasizing its role in enhancing precision and power through prognostic baseline variables. Despite its potential,…

Methodology · Statistics 2026-05-28 Kelly Van Lancker , Iván Díaz , Stijn Vansteelandt

We propose a penalized likelihood method to fit the bivariate categorical response regression model. Our method allows practitioners to estimate which predictors are irrelevant, which predictors only affect the marginal distributions of the…

Methodology · Statistics 2022-01-25 Aaron J. Molstad , Adam J. Rothman

Penalized regression has become a standard tool for model building across a wide range of application domains. Common practice is to tune the amount of penalization to tradeoff bias and variance or to optimize some other measure of…

Methodology · Statistics 2018-04-05 Wenhao Hu , Eric Laber , Leonard Stefanski

Classical penalized likelihood regression problems deal with the case that the independent variables data are known exactly. In practice, however, it is common to observe data with incomplete covariate information. We are concerned with a…

Methodology · Statistics 2010-08-04 Xiwen Ma , Bin Dai , Ronald Klein , Barbara E. K. Klein , Kristine E. Lee , Grace Wahba

Many penalized maximum likelihood estimators correspond to posterior mode estimators under specific prior distributions. Appropriateness of a particular class of penalty functions can therefore be interpreted as the appropriateness of a…

Methodology · Statistics 2018-09-11 Maryclare Griffin , Peter D. Hoff

Regularized models are often sensitive to the scales of the features in the data and it has therefore become standard practice to normalize (center and scale) the features before fitting the model. But there are many different ways to…

Machine Learning · Statistics 2025-07-04 Johan Larsson , Jonas Wallin

Modern statistical learning algorithms are capable of amazing flexibility, but struggle with interpretability. One possible solution is sparsity: making inference such that many of the parameters are estimated as being identically 0, which…

Methodology · Statistics 2023-05-15 Nathan Wycoff , Ali Arab , Katharine M. Donato , Lisa O. Singh

A new method is proposed for variable screening, variable selection and prediction in linear regression problems where the number of predictors can be much larger than the number of observations. The method involves minimizing a penalized…

Statistics Theory · Mathematics 2017-09-14 D. Vasiliu , T. Dey , I. L. Dryden

We consider the estimation of regression models on strata defined using a categorical covariate, in order to identify interactions between this categorical covariate and the other predictors. A basic approach requires the choice of a…

Statistics Theory · Mathematics 2016-11-09 Edouard Ollier , Vivian Viallon

We propose a new method for supervised learning, especially suited to wide data where the number of features is much greater than the number of observations. The method combines the lasso ($\ell_1$) sparsity penalty with a quadratic penalty…

Methodology · Statistics 2018-10-25 J. Kenneth Tay , Jerome Friedman , Robert Tibshirani

Regression adjustments are often considered by investigators to improve the estimation efficiency of causal effect in randomized experiments when there exists many pre-experiment covariates. In this paper, we provide conditions that…

Statistics Theory · Mathematics 2018-09-25 Hanzhong Liu , Yuehan Yang

Features in predictive models are not exchangeable, yet common supervised models treat them as such. Here we study ridge regression when the analyst can partition the features into $K$ groups based on external side-information. For example,…

Methodology · Statistics 2021-03-05 Nikolaos Ignatiadis , Panagiotis Lolas

Bayesian methodologies prioritising accurate associations above sparsity in Gaussian graphical model (GGM) estimation remain relatively scarce in scientific literature. It is well accepted that the $\ell_2$ penalty enjoys a smaller…

Methodology · Statistics 2022-10-31 J. Smith , M. Arashi , A. Bekker

To conduct regression analysis for data contaminated with outliers, many approaches have been proposed for simultaneous outlier detection and robust regression, so is the approach proposed in this manuscript. This new approach is called…

Methodology · Statistics 2016-03-25 Xiaoli Gao , Yixin Fang
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