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We present a novel mathematical model that simulates myocardial blood perfusion by embedding multiscale and multiphysics features. Our model incorporates cardiac electrophysiology, active and passive mechanics, hemodynamics, reduced valve…

Computational Engineering, Finance, and Science · Computer Science 2023-03-27 Alberto Zingaro , Christian Vergara , Luca Dede' , Francesco Regazzoni , Alfio Quarteroni

ECG Feature Extraction plays a significant role in diagnosing most of the cardiac diseases. One cardiac cycle in an ECG signal consists of the P-QRS-T waves. This feature extraction scheme determines the amplitudes and intervals in the ECG…

Neural and Evolutionary Computing · Computer Science 2010-05-07 S. Karpagachelvi , M. Arthanari , M. Sivakumar

We propose four novel mathematical models, describing the microscopic mechanisms of force generation in the cardiac muscle tissue, which are suitable for multiscale numerical simulations of cardiac electromechanics. Such models are based on…

Subcellular Processes · Quantitative Biology 2021-01-27 Francesco Regazzoni , Luca Dedè , Alfio Quarteroni

Background: Artificial intelligence techniques have shown great potential in cardiology, especially in quantifying cardiac biventricular function, volume, mass, and ejection fraction (EF). However, its use in clinical practice is not…

Image and Video Processing · Electrical Eng. & Systems 2022-06-07 Ariel H. Curiale , MatÍas E. Calandrelli , Lucca Dellazoppa , Mariano Trevisan , Jorge Luis BociÁn , Juan Pablo Bonifacio , GermÁn Mato

The lack of large video databases obtained from real patients with respiratory disorders makes the design and optimization of video-based monitoring systems quite critical. The purpose of this study is the development of suitable models and…

Applications · Statistics 2023-07-14 Davide Alinovi , Gianluigi Ferrari , Francesco Pisani , Riccardo Raheli

Objectives: This study examines human Photoplethysmogram (PPG) along with Electrocardiogram (ECG) signals to study cardiac autonomic imbalance in epileptic seizures. The significance and the prevalence of changes in PPG morphological…

Signal Processing · Electrical Eng. & Systems 2019-12-12 Seyede Mahya Safavi , Ninaz Valisharifabad , Robert Sabino , Hsinchung Chen , Ali HeydariGorji , Demi Tran , Jack Lin , Beth Lopour , Pai H. Chou

Cardiovascular disease is a large worldwide healthcare issue; symptoms often present suddenly with minimal warning. The electrocardiogram (ECG) is a fast, simple and reliable method of evaluating the health of the heart, by measuring…

Signal Processing · Electrical Eng. & Systems 2022-01-15 Yola Jones , Fani Deligianni , Jeff Dalton

Combining physics-based modeling with data-driven methods is critical to enabling the translation of computational methods to clinical use in cardiology. The use of rigorous differential equations combined with machine learning tools allows…

Image and Video Processing · Electrical Eng. & Systems 2025-04-30 Elena Martinez , Beatrice Moscoloni , Matteo Salvador , Fanwei Kong , Mathias Peirlinck , Alison Lesley Marsden

Whole-body hemodynamics simulators, which model blood flow and pressure waveforms as functions of physiological parameters, are now essential tools for studying cardiovascular systems. However, solving the corresponding inverse problem of…

Morphology of cardiovascular tissue is influenced by the unsteady behavior of the blood flow and vice versa. Therefore, the pathogenesis of several cardiovascular diseases is directly affected by the blood-flow dynamics. Understanding flow…

Objective: Closed-loop deep brain stimulation (DBS) may improve current clinical DBS treatment for neurological movement disorders, but control algorithms may perform differently across patients. New metrics are needed for comparing and…

Neurons and Cognition · Quantitative Biology 2016-05-31 Jeffrey Herron , Anca Velisar , Mahsa Malekmohammadi , Helen Bronte-Stewart , Howard Jay Chizeck

Frequently, transient changes in physiological signals, such as ECG morphology, precede or follow a rate change. Current methods for visualizing morphology allow only the tracking of preselected changes, severely limiting analytical…

Medical Physics · Physics 2026-02-24 Tomasz Gradowski , Damian Waląg , Tomir Domański , Teodor Buchner

We perform a variational quantum Monte Carlo simulation of an interacting Fermi gas confined in a three dimensional harmonic potential. This gas is considered as the precursor system from which a molecular bosonic gas is formed. Based on…

Other Condensed Matter · Physics 2009-11-11 R. Jauregui , R. Paredes , G. Toledo Sanchez

The electrocardiogram (ECG) is a vital tool for diagnosing heart diseases. However, many disease patterns are derived from outdated datasets and traditional stepwise algorithms with limited accuracy. This study presents a method for direct…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Oğuzhan Büyüksolak , İlkay Öksüz

Hypertension is a potentially unsafe health ailment, which can be indicated directly from the Blood pressure (BP). Hypertension always leads to other health complications. Continuous monitoring of BP is very important; however, cuff-based…

A cardiac digital twin is a virtual replica of a patient-specific heart, mimicking its anatomy and physiology. A crucial step of building a cardiac digital twin is anatomical twinning, where the computational mesh of the digital twin is…

In this paper we will address the problem of developing mathematical models for the numerical simulation of the human circulatory system. In particular, we will focus our attention on the problem of haemodynamics in large human arteries.

Dynamical Systems · Mathematics 2007-05-23 Alfio Quarteroni

We propose a general approach to the question of how biological rhythms spontaneously self-regulate, based on the concept of ``stochastic feedback''. We illustrate this approach by considering the neuroautonomic regulation of the heart…

Statistical Mechanics · Physics 2009-10-30 Plamen Ch. Ivanov , Luis A. N. Amaral , Ary Goldberger , H. Eugene Stanley

Cardiac time intervals (CTIs) are important parameters for assessing cardiac function and can be measured using non-invasive methods such as electrocardiography (ECG) and seismocardiography (SCG). It is widely accepted that SCG signals,…

Medical Physics · Physics 2024-02-13 Aysha Mann , Bahram Kakavand , Peshala Thibbotuwawa Gamage , Amirtahà Taebi

Biomedical signal processing extract meaningful information from physiological signals like electrocardiograms (ECGs), electroencephalograms (EEGs), and electromyograms (EMGs) to diagnose, monitor, and treat medical conditions and diseases…

Signal Processing · Electrical Eng. & Systems 2025-08-13 Justin London